Zobrazeno 1 - 10
of 215
pro vyhledávání: '"John E Pimanda"'
Autor:
Peter Truong, Sylvie Shen, Swapna Joshi, Md Imtiazul Islam, Ling Zhong, Mark J. Raftery, Ali Afrasiabi, Hamid Alinejad-Rokny, Mary Nguyen, Xiaoheng Zou, Golam Sarower Bhuyan, Chowdhury H. Sarowar, Elaheh S. Ghodousi, Olivia Stonehouse, Sara Mohamed, Cara E. Toscan, Patrick Connerty, Purvi M. Kakadia, Stefan K. Bohlander, Katharine A. Michie, Jonas Larsson, Richard B. Lock, Carl R. Walkley, Julie A. I. Thoms, Christopher J. Jolly, John E. Pimanda
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Hypomethylating agents (HMAs) are frontline therapies for Myelodysplastic Neoplasms (MDS) and Acute Myeloid Leukemia (AML). However, acquired resistance and treatment failure are commonplace. To address this, we perform a genome-wide CRISPR-
Externí odkaz:
https://doaj.org/article/73815292edce4c1d9476e3fd55ac41f7
Autor:
Laura A. Richards, Ashu Kumari, Kathy Knezevic, Julie AI Thoms, Georg von Jonquieres, Christine E. Napier, Zara Ali, Rosemary O’Brien, Jonathon Marks-Bluth, Michelle F. Maritz, Hilda A Pickett, Jonathan Morris, John E. Pimanda, Karen L. MacKenzie
Publikováno v:
Haematologica, Vol 105, Iss 6 (2020)
Telomerase is a ribonucleoprotein complex that maintains the length and integrity of telomeres, and thereby enables cellular proliferation. Understanding the regulation of telomerase in hematopoietic cells is relevant to the pathogenesis of leukemia,
Externí odkaz:
https://doaj.org/article/ee07ad5c6c0249799f5927f0f6b11e13
Autor:
Quintin Lee, Matthew P Padula, Natalia Pinello, Simon H Williams, Matthew B O'Rourke, Marcilio Jorge Fumagalli, Joseph D Orkin, Renhua Song, Babak Shaban, Ori Brenner, John E Pimanda, Wolfgang Weninger, William Marciel de Souza, Amanda D Melin, Justin J-L Wong, Marcus J Crim, Sébastien Monette, Ben Roediger, Christopher J Jolly
Publikováno v:
PLoS Pathogens, Vol 16, Iss 1, p e1008262 (2020)
Mouse kidney parvovirus (MKPV) is a member of the provisional genus Chapparvovirus that causes renal disease in immune-compromised mice, with a disease course reminiscent of polyomavirus-associated nephropathy in immune-suppressed kidney transplant p
Externí odkaz:
https://doaj.org/article/c026c4cab9f2416ca6f54b057744ad7f
Autor:
Peter Truong, John E. Pimanda
Publikováno v:
Blood. 141:447-449
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4745e63d8e5fd746f24282f8f3908612
https://doi.org/10.1182/blood.2022018787
https://doi.org/10.1182/blood.2022018787
Autor:
Adrian Schwarzer, Stephan Emmrich, Franziska Schmidt, Dominik Beck, Michelle Ng, Christina Reimer, Felix Ferdinand Adams, Sarah Grasedieck, Damian Witte, Sebastian Käbler, Jason W. H. Wong, Anushi Shah, Yizhou Huang, Razan Jammal, Aliaksandra Maroz, Mojca Jongen-Lavrencic, Axel Schambach, Florian Kuchenbauer, John E. Pimanda, Dirk Reinhardt, Dirk Heckl, Jan-Henning Klusmann
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
While micro-RNAs are known regulators of haematopoiesis and leukemogenesis, the role of long non-coding RNAs is less clear. Here the authors provide a non-coding RNA expression landscape of the human hematopoietic system, highlighting their role in t
Externí odkaz:
https://doaj.org/article/ecded43fcdb64f949d09ac6436b134eb
Autor:
Ashwin Unnikrishnan, Elli Papaemmanuil, Dominik Beck, Nandan P. Deshpande, Arjun Verma, Ashu Kumari, Petter S. Woll, Laura A. Richards, Kathy Knezevic, Vashe Chandrakanthan, Julie A.I. Thoms, Melinda L. Tursky, Yizhou Huang, Zara Ali, Jake Olivier, Sally Galbraith, Austin G. Kulasekararaj, Magnus Tobiasson, Mohsen Karimi, Andrea Pellagatti, Susan R. Wilson, Robert Lindeman, Boris Young, Raj Ramakrishna, Christopher Arthur, Richard Stark, Philip Crispin, Jennifer Curnow, Pauline Warburton, Fernando Roncolato, Jacqueline Boultwood, Kevin Lynch, Sten Eirik W. Jacobsen, Ghulam J. Mufti, Eva Hellstrom-Lindberg, Marc R. Wilkins, Karen L. MacKenzie, Jason W.H. Wong, Peter J. Campbell, John E. Pimanda
Publikováno v:
Cell Reports, Vol 20, Iss 3, Pp 572-585 (2017)
Myelodysplastic syndromes and chronic myelomonocytic leukemia are blood disorders characterized by ineffective hematopoiesis and progressive marrow failure that can transform into acute leukemia. The DNA methyltransferase inhibitor 5-azacytidine (AZA
Externí odkaz:
https://doaj.org/article/fb18143a8ba041a5a64d9408be566baa
Autor:
Ernest Moles, Christopher B. Howard, Pie Huda, Mawar Karsa, Hannah McCalmont, Kathleen Kimpton, Alastair Duly, Yongjuan Chen, Yizhou Huang, Melinda L. Tursky, David Ma, Sonia Bustamante, Russell Pickford, Patrick Connerty, Sofia Omari, Christopher J. Jolly, Swapna Joshi, Sylvie Shen, John E. Pimanda, Alla Dolnikov, Laurence C. Cheung, Rishi S. Kotecha, Murray D. Norris, Michelle Haber, Charles E. de Bock, Klaartje Somers, Richard B. Lock, Kristofer J. Thurecht, Maria Kavallaris
Publikováno v:
Science Translational Medicine. 15
High-risk childhood leukemia has a poor prognosis because of treatment failure and toxic side effects of therapy. Drug encapsulation into liposomal nanocarriers has shown clinical success at improving biodistribution and tolerability of chemotherapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcc188efb9125cf1c20a439c99f70c47
https://doi.org/10.1126/scitranslmed.abm1262
https://doi.org/10.1126/scitranslmed.abm1262
Autor:
ShuhYing Tan, Chacko Joseph, Alistair M. Chalk, Jean Hendy, Stewart Fabb, Kelli Schleibs, Samuel C. Lee, Gavin Tjin, Clea S. Grace, Vinodini Madugalle, Monique F. Smeets, Ana C. Maluenda, Kim L. Rice, Emma K. Baker, Harshal Nandurkar, Christopher I. Slape, Michael W Parker, Ashwin Unnikrishnan, Ghulam J. Mufti, Magnus Tobiasson, Eva Hellstrom-Lindberg, John E. Pimanda, Lorraine J. Gudas, Jessica K. Holien, Carl R. Walkley, Meaghan Wall, Louise E. Purton
The homeobox gene,Hoxa1, has two different isoforms generated by alternative splicing: a full-length homeodomain-containingHoxa1(Hoxa1-FL), and a truncatedHoxa1(Hoxa1-T), that lacks the homeodomain. Oncoretroviral overexpression of wildtypeHoxa1cDNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70e33ff44b2fdccd0e106a5dee92ae00
https://doi.org/10.1101/2023.04.24.538176
https://doi.org/10.1101/2023.04.24.538176
Autor:
Shruthi Subramanian, Julie A.I. Thoms, Yizhou Huang, Paola Cornejo, Forrest C. Koch, Sebastien Jacquelin, Sylvie Shen, Emma Song, Swapna Joshi, Chris Brownlee, Petter S. Woll, Diego Chacon Fajardo, Dominik Beck, David J. Curtis, Kenneth Yehson, Vicki Antonenas, Tracey O’ Brien, Annette Trickett, Jason A. Powell, Ian D. Lewis, Stuart M. Pitson, Maher K. Gandhi, Steven W. Lane, Fatemeh Vafaee, Emily S. Wong, Berthold Göttgens, Hamid Alinejad Rokny, Jason W.H Wong, John E. Pimanda
SummaryHematopoietic stem and progenitor cells (HSPCs) rely on a complex interplay of transcription factors (TFs) to regulate differentiation into mature blood cells. A heptad of TFs - FLI1, ERG, GATA2, RUNX1, TAL1, LYL1, LMO2 - bind regulatory eleme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41942e05e1ce4a56162d13a406b33d8c
https://doi.org/10.1101/2023.04.18.537282
https://doi.org/10.1101/2023.04.18.537282
Autor:
Robyn L. Ward, Jason W.H. Wong, Michael J. Bourke, Nicholas J. Hawkins, Mathew A. Sloane, John E. Pimanda, Caroline E. Ford, Ashraf Dower, Regina Ryan, Dominik Beck, Andrea C. Nunez, Deborah Packham, Chau-To Kwok, Sameer Srivastava, Peter Zarzour, Benedict Ng, Luke B. Hesson
Supplementary Figure S1. LSTs profiled in this study. Supplementary Figure S2. Mutation validation by Sanger sequencing. Supplementary Figure S3. Analytical strategy for identifying LST driver genes and significantly altered pathways. Supplementary F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf457a7e77c5ad70f774c7d2ceabd98
https://doi.org/10.1158/1541-7786.22511728
https://doi.org/10.1158/1541-7786.22511728