Zobrazeno 1 - 10
of 51
pro vyhledávání: '"John E Pak"'
Autor:
Robert R Puccinelli, Samia S Sama, Caroline M Worthington, Andreas S Puschnik, John E Pak, Rafael Gómez-Sjöberg
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0297879 (2024)
Liquid chromatography purification of multiple recombinant proteins, in parallel, could catalyze research and discovery if the processes are fast and approach the robustness of traditional, "one-protein-at-a-time" purification. Here, we report an aut
Externí odkaz:
https://doaj.org/article/83099ea7a9e44da6965a60ff7129b4f4
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 9, p e1010052 (2022)
The sequencing of antibody repertoires of B-cells at increasing coverage and depth has led to the identification of vast numbers of immunoglobulin heavy and light chains. However, the size and complexity of these Adaptive Immune Receptor Repertoire s
Externí odkaz:
https://doaj.org/article/e3763f3c7aec427981046b60a21567e4
Autor:
Natasha D Durham, Aditi Agrawal, Eric Waltari, Derek Croote, Fabio Zanini, Mallorie Fouch, Edgar Davidson, Olivia Smith, Esteban Carabajal, John E Pak, Benjamin J Doranz, Makeda Robinson, Ana M Sanz, Ludwig L Albornoz, Fernando Rosso, Shirit Einav, Stephen R Quake, Krista M McCutcheon, Leslie Goo
Publikováno v:
eLife, Vol 8 (2019)
Eliciting broadly neutralizing antibodies (bNAbs) against the four dengue virus serotypes (DENV1-4) that are spreading into new territories is an important goal of vaccine design. To define bNAb targets, we characterized 28 antibodies belonging to ex
Externí odkaz:
https://doaj.org/article/ccae0927312e48c899d2a400f15ffaf6
Autor:
Jonathan B Leano, Samir Batarni, Jacob Eriksen, Narinobu Juge, John E Pak, Tomomi Kimura-Someya, Yaneth Robles-Colmenares, Yoshinori Moriyama, Robert M Stroud, Robert H Edwards
Publikováno v:
PLoS Biology, Vol 17, Iss 5, p e3000260 (2019)
Members of the solute carrier 17 (SLC17) family use divergent mechanisms to concentrate organic anions. Membrane potential drives uptake of the principal excitatory neurotransmitter glutamate into synaptic vesicles, whereas closely related proteins u
Externí odkaz:
https://doaj.org/article/65102fbea5e242989c390f1b3737e279
Autor:
Brian L. Hie, Varun R. Shanker, Duo Xu, Theodora U. J. Bruun, Payton A. Weidenbacher, Shaogeng Tang, Wesley Wu, John E. Pak, Peter S. Kim
Publikováno v:
Nature Biotechnology.
Natural evolution must explore a vast landscape of possible sequences for desirable yet rare mutations, suggesting that learning from natural evolutionary strategies could guide artificial evolution. Here we report that general protein language model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1fb6b62a9f8f2d6ca47ab61260b6c6d
https://doi.org/10.1038/s41587-023-01763-2
https://doi.org/10.1038/s41587-023-01763-2
Autor:
Scott B. Biering, Francielle Tramontini Gomes de Sousa, Laurentia V. Tjang, Felix Pahmeier, Chi Zhu, Richard Ruan, Sophie F. Blanc, Trishna S. Patel, Caroline M. Worthington, Dustin R. Glasner, Bryan Castillo-Rojas, Venice Servellita, Nicholas T. N. Lo, Marcus P. Wong, Colin M. Warnes, Daniel R. Sandoval, Thomas Mandel Clausen, Yale A. Santos, Douglas M. Fox, Victoria Ortega, Anders M. Näär, Ralph S. Baric, Sarah A. Stanley, Hector C. Aguilar, Jeffrey D. Esko, Charles Y. Chiu, John E. Pak, P. Robert Beatty, Eva Harris
Publikováno v:
Nature communications, vol 13, iss 1
Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction within the lung as well as in distal organs. While it is appreciated that an exaggerated inflammatory response is associated with barrier dysfunction, the triggers of v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68f6227f58b82f3d83f58e2123bd474
https://doi.org/10.1038/s41467-022-34910-5
https://doi.org/10.1038/s41467-022-34910-5
Autor:
Alan H.B. Wu, Wesley Wu, Isobel Routledge, Saki Takahashi, Chui Mei Ong, Edward Thornborrow, Lee Besana, Jessica Briggs, Michael J. Peluso, Kirk Sujishi, Timothy J. Henrich, Ching Ying Oon, Keirstinne Turcios, Cassandra Yun, Marcelina Coh, Wai Kit Ho, Joanna Vinden, Owen Janson, Elias Duarte, Jill Hakim, Kara L. Lynch, Isabel Rodriguez-Barraquer, Adrienne Epstein, John E. Pak, William J. Karlon, Jesus Rangel, Bryan Greenhouse
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature communications, vol 12, iss 1
Nature Communications
Nature communications, vol 12, iss 1
Nature Communications
Serosurveillance provides a unique opportunity to quantify the proportion of the population that has been exposed to pathogens. Here, we developed and piloted Serosurveillance for Continuous, ActionabLe Epidemiologic Intelligence of Transmission (SCA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2930edb1a467a7475c3da3872460df0d
https://doaj.org/article/2c73ad75f25940cfa9325487cf55c8e4
https://doaj.org/article/2c73ad75f25940cfa9325487cf55c8e4
Autor:
Janie R. Byrum, Eric Waltari, Owen Janson, Syuan-Ming Guo, Jenny Folkesson, Bryant B. Chhun, Joanna Vinden, Ivan E. Ivanov, Marcus L. Forst, Hongquan Li, Adam G. Larson, Lena Blackmon, Ziwen Liu, Wesley Wu, Vida Ahyong, Cristina M. Tato, Krista M. McCutcheon, Rebecca Hoh, J. Daniel Kelly, Jeffrey N. Martin, Michael J. Peluso, Timothy J. Henrich, Steven G. Deeks, Manu Prakash, Bryan Greenhouse, Shalin B. Mehta, John E. Pak
Publikováno v:
Pathogens; Volume 12; Issue 5; Pages: 671
A multiplexed enzyme-linked immunosorbent assay (ELISA) that simultaneously measures antibody binding to multiple antigens can extend the impact of serosurveillance studies, particularly if the assay approaches the simplicity, robustness, and accurac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d05cc2f9aed8f352981cbc5da73f66
https://doi.org/10.3390/pathogens12050671
https://doi.org/10.3390/pathogens12050671
Autor:
John E. Pak, Sanghwa Jeong, Hung Yu Sun, Lili Kuo, Markita P. Landry, Nicole Navarro, Francis Ledesma, Yung Chun Chuang, Darwin Yang, Rebecca L. Pinals, Yu Wei Cheng
Publikováno v:
medRxiv
To effectively track and eliminate COVID-19, it is critical to develop tools for rapid and accessible diagnosis of actively infected individuals. Here, we introduce a single-walled carbon nanotube (SWCNT)-based optical sensing approach towards these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f60854628c9f4185b01f790b325e37b
https://doi.org/10.1021/acs.nanolett.1c00118
https://doi.org/10.1021/acs.nanolett.1c00118
Autor:
Payton A-B, Weidenbacher, Eric, Waltari, Izumi, de Los Rios Kobara, Benjamin N, Bell, Mary Kate, Morris, Ya-Chen, Cheng, Carl, Hanson, John E, Pak, Peter S, Kim
Publikováno v:
Nature chemical biology. 18(11)
Omicron and its subvariants have rendered most authorized monoclonal antibody-based treatments for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ineffective, highlighting the need for biologics capable of overcoming SARS-CoV-2 evolutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a1b84a40a365f86121a0d2b6ff796dc0
https://pubmed.ncbi.nlm.nih.gov/36076082
https://pubmed.ncbi.nlm.nih.gov/36076082