Zobrazeno 1 - 10
of 132
pro vyhledávání: '"John E Nielsen"'
Autor:
Malene Lundgaard Riis, Gaspard Delpouve, John E. Nielsen, Cecilie Melau, Lea Langhoff Thuesen, Kristine Juul Hare, Eva Dreisler, Kasper Aaboe, Pia Tutein Brenøe, Jakob Albrethsen, Hanne Frederiksen, Anders Juul, Paolo Giacobini, Anne Jørgensen
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Sex-specific gonadal differentiation is directed by complex signalling promoting development in either male or female direction, while simultaneously inhibiting the opposite pathway. In mice, the WNT/β-catenin pathway promotes ovarian devel
Externí odkaz:
https://doaj.org/article/9ba84127f86e43e4b357207164f53583
Autor:
Malene Lundgaard Riis, Gabriele Matilionyte, John E. Nielsen, Cecilie Melau, David Greenald, Kristine Juul Hare, Lea Langhoff Thuesen, Eva Dreisler, Kasper Aaboe, Pia Tutein Brenøe, Anna-Maria Andersson, Jakob Albrethsen, Hanne Frederiksen, Ewa Rajpert-De Meyts, Anders Juul, Rod T. Mitchell, Anne Jørgensen
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Reduced androgen action during early fetal development has been suggested as the origin of reproductive disorders comprised within the testicular dysgenesis syndrome (TDS). This hypothesis has been supported by studies in rats dem
Externí odkaz:
https://doaj.org/article/6faa0696ef594229b30882d592bea05d
Autor:
Cecilie Melau, Berta Gayete Mor, Malene Lundgaard Riis, John E. Nielsen, Eva Dreisler, Kasper Aaboe, Pia Tutein Brenøe, Lea Langhoff Thuesen, Kristine Juul Hare, Rod T. Mitchell, Hanne Frederiksen, Anders Juul, Anne Jørgensen
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionAdministration of dexamethasone (DEX) has been used experimentally to suppress androgenization of external genitalia in 46,XX fetuses with congenital adrenal hyperplasia. Despite this, the prenatal biological mechanism-of-action of DEX on
Externí odkaz:
https://doaj.org/article/9b1a8f93d0f24ffb836d637b277bbce2
Autor:
Cecilie Melau, Malene Lundgaard Riis, John E. Nielsen, Signe Perlman, Lene Lundvall, Lea Langhoff Thuesen, Kristine Juul Hare, Mette Schou Hammerum, Rod T. Mitchell, Hanne Frederiksen, Anders Juul, Anne Jørgensen
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-17 (2021)
Abstract Background Disordered fetal adrenal steroidogenesis can cause marked clinical effects including virilization of female fetuses. In postnatal life, adrenal disorders can be life-threatening due to the risk of adrenal crisis and must be carefu
Externí odkaz:
https://doaj.org/article/4b092556ccf84c61a965df50527835b1
Autor:
Graham A. Wood, John E. Nielsen
Publikováno v:
Nota Lepidopterologica, Vol 41, Iss 2, Pp 215-218 (2018)
A specimen of Papilio aegeus ormenus with a forewing/hindwing pattern homeosis is described from Mer Island, Torres Strait, Queensland, Australia. This represents the first record of a butterfly specimen with wing pattern homeosis from Australia.
Externí odkaz:
https://doaj.org/article/b8b8b0feae104df19d8a3f20e661ea29
Autor:
Benedikte von Spreckelsen, Lise Aksglaede, Trine Holm Johannsen, John E. Nielsen, Katharina M. Main, Anne Jørgensen, Rikke Beck Jensen
Publikováno v:
Journal of Pediatric Endocrinology and Metabolism. 35:953-961
Objectives 17β-hydroxysteroid dehydrogenase 3 (17β-HSD3) deficiency results in insufficient biosynthesis of testosterone and consequently dihydrotestosterone. This is important for the fetal development of male genitalia. Thus, most 46,XY patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3275c556c833585bc546221c4339555a
https://doi.org/10.1515/jpem-2021-0713
https://doi.org/10.1515/jpem-2021-0713
Autor:
Christine Hjorth Andreassen, Mette Lorenzen, John E. Nielsen, Sam Kafai Yahyavi, Birgitte Grønkær Toft, Lars R. Ingerslev, Christoffer Clemmensen, Lene Juel Rasmussen, Carsten Bokemeyer, Anders Juul, Anne Jørgensen, Martin Blomberg Jensen
Publikováno v:
Br J Cancer
BACKGROUND: Testicular germ cell tumours (TGCTs) have a high sensitivity to chemotherapy and a high cure rate, although with serious adverse effects. In the search for tumour suppressive drugs, the RANKL inhibitor Denosumab, used to treat osteoporosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c130ee928c68a233d469761dd4e640
https://doi.org/10.1038/s41416-022-01810-w
https://doi.org/10.1038/s41416-022-01810-w
Autor:
Henrik Leffers, Ewa Rajpert-De Meyts, Niels E. Skakkebæk, John E. Nielsen, Wilhelm Ansorge, Christian Schwager, Jonathon Blake, Ute Wirkner, Christina E. Hoei-Hansen, Kristian Almstrup
Carcinoma in situ (CIS) is the common precursor of histologically heterogeneous testicular germ cell tumors (TGCTs), which in recent decades have markedly increased and now are the most common malignancy of young men. Using genome-wide gene expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebe1450a544f24d7e4fd3a9b8a00e2d
https://doi.org/10.1158/0008-5472.c.6493599
https://doi.org/10.1158/0008-5472.c.6493599
Autor:
Henrik Leffers, Ewa Rajpert-De Meyts, Niels E. Skakkebæk, John E. Nielsen, Wilhelm Ansorge, Christian Schwager, Jonathon Blake, Ute Wirkner, Christina E. Hoei-Hansen, Kristian Almstrup
Genes found up-regulated in testicular samples with CIS (fold change)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0faba21ea33551097cefa72fd512bbc3
https://doi.org/10.1158/0008-5472.22363200.v1
https://doi.org/10.1158/0008-5472.22363200.v1
Autor:
Henrik Leffers, Ewa Rajpert-De Meyts, Niels E. Skakkebæk, John E. Nielsen, Wilhelm Ansorge, Christian Schwager, Jonathon Blake, Ute Wirkner, Christina E. Hoei-Hansen, Kristian Almstrup
Supplementary Figure 2 from Embryonic Stem Cell-Like Features of Testicular Carcinoma in Situ Revealed by Genome-Wide Gene Expression Profiling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33aa9bb40b7030390a49f0b0fba43d86
https://doi.org/10.1158/0008-5472.22363206
https://doi.org/10.1158/0008-5472.22363206