Zobrazeno 1 - 10
of 64
pro vyhledávání: '"John E M Midgley"'
Publikováno v:
Therapeutic Advances in Endocrinology and Metabolism, Vol 14 (2023)
Background: Thyroid hormones are controlled by the hypothalamic–pituitary–thyroid (HPT) axis through a complex network of regulatory loops, involving the hormones TRH, TSH, FT4, and FT3. The relationship between TSH and FT4 is widely used for dia
Externí odkaz:
https://doaj.org/article/944d026a2fab4c45b525bb41f59166b0
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Endocrine regulation in the hypothalamic-pituitary-thyroid (HPT) axis is orchestrated by physiological circuits which integrate multiple internal and external influences. Essentially, it provides either of the two responses to overt biological challe
Externí odkaz:
https://doaj.org/article/a6382158f0cf4200a150a2f0d15ee32c
Publikováno v:
Drugs in Context, Vol 8, Pp 1-18 (2019)
Levothyroxine (LT4) therapy has a long history, a well-defined pharmacological profile and a favourable safety record in the alleviation of hypothyroidism. However, questions remain in defining the threshold for the requirement of treatment in patien
Externí odkaz:
https://doaj.org/article/7a37aa97e1a04b3d83a5cac22483a1c3
Publikováno v:
BMC Endocrine Disorders, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background In the treatment for hypothyroidism, a historically symptom-orientated approach has given way to reliance on a single biochemical parameter, thyroid stimulating hormone (TSH). Main body The historical developments and motivation l
Externí odkaz:
https://doaj.org/article/23e386b22e174877add35b6694fdb96f
Autor:
Johannes Wolfgang Dietrich, Rudolf Hoermann, John E. M. Midgley, Friederike Bergen, Patrick Müller
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Elevated concentrations of free thyroid hormones are established cardiovascular risk factors, but the association of thyrotropin (TSH) levels to hard endpoints is less clear. This may, at least in part, ensue from the fact that TSH secretion depends
Externí odkaz:
https://doaj.org/article/f105b1b4111849da9b62ef76fb43219a
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Background: For significant numbers of patients dissatisfied on standard levothyroxine (LT4) treatment for hypothyroidism, patient-specific responses to T4 could play a significant role.Aim: To assess response heterogeneity to LT4 treatment, identify
Externí odkaz:
https://doaj.org/article/36394b96139d41e0af703fab2bc8e1fd
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Externí odkaz:
https://doaj.org/article/cabc6f19bb92461bacfd517fd987e15b
Publikováno v:
Journal of Thyroid Research, Vol 2018 (2018)
Randomised controlled trials are deemed to be the strongest class of evidence in evidence-based medicine. Failure of trials to prove superiority of T3/T4 combination therapy over standard LT4 monotherapy has greatly influenced guidelines, while not r
Externí odkaz:
https://doaj.org/article/af767b3410f94c3fbc3c667bca8baf97
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2017)
In thyroid health, the pituitary hormone thyroid-stimulating hormone (TSH) raises glandular thyroid hormone production to a physiological level and enhances formation and conversion of T4 to the biologically more active T3. Overstimulation is limited
Externí odkaz:
https://doaj.org/article/fba70484ecea4f66a7a5541fd800e9f2
Publikováno v:
Therapeutic Advances in Endocrinology and Metabolism, Vol 8 (2017)
Background: Patient responses to levothyroxine (LT4) monotherapy vary considerably. We sought to differentiate contributions of FT4 and FT3 in controlling pituitary thyroid stimulating hormone (TSH) secretion. Methods: We retrospectively assessed the
Externí odkaz:
https://doaj.org/article/f3c418cf87a34225bf4af8671151040c