Zobrazeno 1 - 10
of 203
pro vyhledávání: '"John E Lisman"'
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130457 (2015)
Because CaMKII is the critical Ca(2+) sensor that triggers long-term potentiation (LTP), understanding its activation and deactivation is important. A major advance has been the development of a FRET indicator of the conformational state of CaMKII ca
Externí odkaz:
https://doaj.org/article/e5e468eeee1645e5aa52d7410bc90d3c
Autor:
Anatoli Y Kabakov, John E Lisman
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123718 (2015)
During long-term potentiation (LTP) of excitatory synapses, Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is activated by Ca(2+) influx through NMDA receptors that potentiate AMPA receptor currents by insertion of additional GluR1-containing
Externí odkaz:
https://doaj.org/article/dd65bcb718294bfb8166794c2fe78d79
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 5, p e1003641 (2014)
The notion of attractor networks is the leading hypothesis for how associative memories are stored and recalled. A defining anatomical feature of such networks is excitatory recurrent connections. These "attract" the firing pattern of the network to
Externí odkaz:
https://doaj.org/article/00866c14403e4b499cf9feae0efecb44
Autor:
John E Lisman
Publikováno v:
eLife, Vol 3 (2014)
The exchange of CaMKII enzymes between larger structures called holoenzymes may provide the molecular mechanism underlying the long-term stability of memories.
Externí odkaz:
https://doaj.org/article/245cfcd27173444da70c868b05713c19
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41908 (2012)
NMDAR antagonists can evoke delta frequency bursting in the nucleus reticularis of the thalamus (nRT). The mechanism of this oscillation was determined; antagonist blocks an NR2C-like conductance that has low Mg block at resting potential and thus ca
Externí odkaz:
https://doaj.org/article/aec749e27d4648be8b733226ac058cc1
Publikováno v:
Frontiers in Computational Neuroscience, Vol 5 (2011)
Visual object recognition occurs easily despite differences in position, size, and rotation of the object, but the neural mechanisms responsible for this invariance are not known. We have found a set of transforms that achieve invariance in a neurall
Externí odkaz:
https://doaj.org/article/2b095cb4c1b24f78834f5142f8439f71
Publikováno v:
PLoS Biology, Vol 3, Iss 4, p e107 (2005)
Molecular switches have been implicated in the storage of information in biological systems. For small structures such as synapses, these switches are composed of only a few molecules and stochastic fluctuations are therefore of importance. Such fluc
Externí odkaz:
https://doaj.org/article/28bd9b5389fa455ebbc8e7dbff72087c
Autor:
Nicole L. Rumian, Carolyn Nicole Brown, Tara B. Hendry-Hofer, Thomas Rossetti, James E. Orfila, Jonathan E. Tullis, Linda P. Dwoskin, Olivia R. Buonarati, John E. Lisman, Nidia Quillinan, Paco S. Herson, Vikhyat S. Bebarta, K. Ulrich Bayer
Publikováno v:
Journal of Biological Chemistry. 299:104693
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2662ae6f87510f9520c9354af0475a1
https://doi.org/10.1016/j.jbc.2023.104693
https://doi.org/10.1016/j.jbc.2023.104693
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
In the classical view of economic choices, subjects make rational decisions evaluating the costs and benefits of options in order to maximize their overall income. Nonetheless, subjects often fail to reach optimal outcomes. The overt value of an opti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01726af468c9b1c19403b99d8b77ff4
https://doi.org/10.1038/s41598-020-79949-w
https://doi.org/10.1038/s41598-020-79949-w
Publikováno v:
Neurobiol Learn Mem
Background Working memory deficits are key cognitive symptoms of schizophrenia. Elevated delta oscillations, which are uniquely associated with the presence of the illness, may be the proximal cause of these deficits. Spatial working memory (SWM) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03bfa130efd9f5bf4a873592e8278503
https://pubmed.ncbi.nlm.nih.gov/33524571
https://pubmed.ncbi.nlm.nih.gov/33524571