Zobrazeno 1 - 10
of 48
pro vyhledávání: '"John E Harrison"'
Autor:
Rosanne L. van den Berg, Casper de Boer, Marissa D. Zwan, Roos J. Jutten, Mariska van Liere, Marie-Christine A.B.J. van de Glind, Mark A. Dubbelman, Lisa Marie Schlüter, Argonde C. van Harten, Charlotte E. Teunissen, Elsmarieke van de Giessen, Frederik Barkhof, Lyduine E. Collij, Jessica Robin, William Simpson, John E Harrison, Wiesje M. van der Flier, Sietske A.M. Sikkes
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Digital speech assessment has potential relevance in the earliest, preclinical stages of Alzheimer’s disease (AD). We evaluated the feasibility, test-retest reliability, and association with AD-related amyloid-beta (Aβ) patholo
Externí odkaz:
https://doaj.org/article/75ea7ee6329e4654a1896779b7cc2a38
Autor:
Jennifer Rae Myers, Jordan M Glenn, Erica N Madero, John Anderson, Rachel Mak-McCully, Michelle Gray, Joshua L Gills, John E Harrison
Publikováno v:
JMIR Formative Research, Vol 6, Iss 2, p e34237 (2022)
BackgroundAs evidenced by the further reduction in access to testing during the COVID-19 pandemic, there is an urgent, growing need for remote cognitive assessment for individuals with cognitive impairment. The Neurotrack Cognitive Battery (NCB), our
Externí odkaz:
https://doaj.org/article/e9c661fbe75344f2972fee08608cbeba
Autor:
Jessica Robin, John E. Harrison, Liam D. Kaufman, Frank Rudzicz, William Simpson, Maria Yancheva
Publikováno v:
Digital Biomarkers, Vol 4, Iss 3, Pp 99-108 (2020)
Speech represents a promising novel biomarker by providing a window into brain health, as shown by its disruption in various neurological and psychiatric diseases. As with many novel digital biomarkers, however, rigorous evaluation is currently lacki
Externí odkaz:
https://doaj.org/article/844afa83d48843669880f73dcfbd62cc
Autor:
Martí Colom-Cadena, Tara Spires-Jones, Henrik Zetterberg, Kaj Blennow, Anthony Caggiano, Steven T. DeKosky, Howard Fillit, John E. Harrison, Lon S. Schneider, Phillip Scheltens, Willem de Haan, Michael Grundman, Christopher H. van Dyck, Nicholas J. Izzo, Susan M. Catalano, the Synaptic Health Endpoints Working Group
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-12 (2020)
Abstract Background Synapse damage and loss are fundamental to the pathophysiology of Alzheimer’s disease (AD) and lead to reduced cognitive function. The goal of this review is to address the challenges of forging new clinical development approach
Externí odkaz:
https://doaj.org/article/1df4eea74a444af7b16f1b08d1784dd1
Autor:
Roos J. Jutten, John E. Harrison, Philippe R. Lee Meeuw Kjoe, Silvia Ingala, R. Vreeswijk, R. A. J. van Deelen, Frank Jan de Jong, Esther M. Opmeer, André Aleman, Craig W. Ritchie, Philip Scheltens, Sietske A. M. Sikkes
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-13 (2019)
Abstract Background The cognitive-functional composite (CFC) was designed to improve the measurement of clinically relevant changes in predementia and early dementia stages. We have previously demonstrated its good test-retest reliability and feasibi
Externí odkaz:
https://doaj.org/article/9644582a6a1243f1ad2d9b175275d29d
Autor:
Roos J. Jutten, John E. Harrison, A.J. Brunner, R. Vreeswijk, R.A.J. vanDeelen, Frank Jan de Jong, Esther M. Opmeer, Craig W. Ritchie, André Aleman, Philip Scheltens, Sietske A.M. Sikkes
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction In an attempt to capture clinically meaningful cognitive decline in early dementia, we developed the Cognitive‐Functional Composite (CFC). We investigated the CFC's sensitivity to decline in comparison to traditional clinical
Externí odkaz:
https://doaj.org/article/b1ceef35a87b4a8fb8b76b89c248f78b
Autor:
John E. Harrison
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract In this commentary I consider the issues raised in Schneider and Goldberg's review of composite cognitive and functional measures. I find much to agree with in their commentary and especially their concerns regarding satisfactory psychometri
Externí odkaz:
https://doaj.org/article/9d058ce7a5dc49c68ca8c4e0e38227b6
Autor:
John E. Harrison
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-6 (2018)
Abstract Background The FDA have recently published draft guidance for the development of treatments for early Alzheimer’s disease. Key features of this guidance are the advocacy of sensitive cognitive measures and a taxonomy of disease severity. W
Externí odkaz:
https://doaj.org/article/0aee91ff79124ed0b76576cf1fca72a6
Autor:
Ying Jiang, John J. Alam, Stephen N. Gomperts, Paul Maruff, Afina W. Lemstra, Ursula A. Germann, Philip H. Stavrides, Sandipkumar Darji, Sandeep Malampati, James Peddy, Cynthia Bleiwas, Monika Pawlik, Anna Pensalfini, Dun-Sheng Yang, Shivakumar Subbanna, Balapal S. Basavarajappa, John F. Smiley, Amanda Gardner, Kelly Blackburn, Hui-May Chu, Niels D. Prins, Charlotte E. Teunissen, John E. Harrison, Philip Scheltens, Ralph A. Nixon
Publikováno v:
Jiang, Y, Alam, J J, Gomperts, S N, Maruff, P, Lemstra, A W, Germann, U A, Stavrides, P H, Darji, S, Malampati, S, Peddy, J, Bleiwas, C, Pawlik, M, Pensalfini, A, Yang, D-S, Subbanna, S, Basavarajappa, B S, Smiley, J F, Gardner, A, Blackburn, K, Chu, H-M, Prins, N D, Teunissen, C E, Harrison, J E, Scheltens, P & Nixon, R A 2022, ' Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration ', Nature Communications, vol. 13, no. 1, 5308 . https://doi.org/10.1038/s41467-022-32944-3
Nature Communications, 13(1):5308. Nature Publishing Group UK
Nature Communications, 13(1):5308. Nature Publishing Group UK
The endosome-associated GTPase Rab5 is a central player in the molecular mechanisms leading to degeneration of basal forebrain cholinergic neurons (BFCN), a long-standing target for drug development. As p38α is a Rab5 activator, we hypothesized that
Publikováno v:
International Journal of Methods in Psychiatric Research. 31
We report further validation and normative data for the THINC-Integrated Tool (THINC-it), a measure of cognitive function designed for use with individuals living with Major Depressive Disorder, but which is finding use in further psychiatric and neu