Zobrazeno 1 - 10
of 251
pro vyhledávání: '"John E Harris"'
Autor:
Hilda E Ramón, Pedro J Cejas, David LaRosa, Adeeb Rahman, John E Harris, Jidong Zhang, Christopher Hunter, Yongwon Choi, Laurence A Turka
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12904 (2010)
BackgroundThe zinc finger transcription factor EGR-2 has been shown to play an important role in the induction of T cell anergy and the regulation of peripheral T cell tolerance. In vitro, a prior study has show that T cells deficient in EGR-2 are hy
Externí odkaz:
https://doaj.org/article/e12be66e2b8442d0b9e35c38c7646539
Autor:
Rhea Singh, BS, Jay L. Cohen, MD, Michael Astudillo, MD, John E. Harris, MD, PhD, Esther E. Freeman, MD, PhD
Publikováno v:
JAAD Case Reports, Vol 28, Iss , Pp 142-144 (2022)
Externí odkaz:
https://doaj.org/article/0f43d5a59f0543bba23c548fae5e7e23
Autor:
Ying-Chao Hsueh, Yuzhen Wang, Rebecca L. Riding, Donna E. Catalano, Yu-Jung Lu, Jillian M. Richmond, Don L. Siegel, Mary Rusckowski, John R. Stanley, John E. Harris
Publikováno v:
Journal of Investigative Dermatology. 142:3294-3303
Despite the central role of IFN-γ in vitiligo pathogenesis, systemic IFN-γ neutralization is an impractical treatment option owing to strong immunosuppression. However, most patients with vitiligo present with20% affected body surface area, which p
Autor:
Qi Tang, Jacquelyn Sousa, Dimas Echeverria, Xueli Fan, Ying-Chao Hsueh, Khashayar Afshari, Nicholas MeHugh, David A. Cooper, Lorenc Vangjeli, Kathryn Monopoli, Ken Okamura, Annabelle Biscans, Adam Clauss, John E. Harris, Anastasia Khvorova
Publikováno v:
Molecular Therapy. 30:2709-2721
Aberrant activation of interferon (IFN)-γ signaling plays a key role in several autoimmune skin diseases, including lupus erythematosus, alopecia areata, vitiligo, and lichen planus. Here, we identify fully chemically modified small interfering RNAs
Autor:
Hongyi Ren, Andressa L. Akabane, Kiera Kelleher, Caroline Halverstam, Maria Hicks, Jordana R. Schachter, Robert Silverman, Samuel Chachkin, Shany Sherman‐Bergman, John E. Harris, Victoria Kuohung
Publikováno v:
Journal of the European Academy of Dermatology and Venereology.
Autor:
Alice B. Gottlieb, Amit G. Pandya, Mark Lebwohl, Kathleen Butler, Kang Sun, Iltefat H. Hamzavi, Fiona Kuo, Pearl E. Grimes, David Rosmarin, John E. Harris
Publikováno v:
Journal of the American Academy of Dermatology. 86:1398-1401
Publikováno v:
Pediatric Dermatology.
Publikováno v:
Journal of the American Academy of Dermatology.
Autor:
Rosanne L. van den Berg, Casper de Boer, Marissa D. Zwan, Roos J. Jutten, Mariska van Liere, Marie-Christine A.B.J. van de Glind, Mark A. Dubbelman, Lisa Marie Schlüter, Argonde C. van Harten, Charlotte E. Teunissen, Elsmarieke van de Giessen, Frederik Barkhof, Lyduine E. Collij, Jessica Robin, William Simpson, John E Harrison, Wiesje M. van der Flier, Sietske A.M. Sikkes
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Digital speech assessment has potential relevance in the earliest, preclinical stages of Alzheimer’s disease (AD). We evaluated the feasibility, test-retest reliability, and association with AD-related amyloid-beta (Aβ) patholo
Externí odkaz:
https://doaj.org/article/75ea7ee6329e4654a1896779b7cc2a38
Autor:
Jeffrey Y. Zhou, Mrinal K. Sarkar, Ken Okamura, John E. Harris, Johann E. Gudjonsson, Katherine A. Fitzgerald
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The accrual of cytosolic DNA leads to transcription of type I IFNs, proteolytic maturation of the IL-1 family of cytokines, and pyroptotic cell death. Caspase-1 cleaves pro-IL1β to generate mature bioactive cytokine and gasdermin D which facilitates