Zobrazeno 1 - 3
of 3
pro vyhledávání: '"John E Goodall"'
Autor:
Jeffrey J Wallin, Jane Guan, Kyle A Edgar, Wei Zhou, Ross Francis, Anthony C Torres, Peter M Haverty, Jeffrey Eastham-Anderson, Sabrina Arena, Alberto Bardelli, Sue Griffin, John E Goodall, Kyla M Grimshaw, Klaus P Hoeflich, Christopher Torrance, Marcia Belvin, Lori S Friedman
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36402 (2012)
The PTEN/PI3K pathway is commonly mutated in cancer and therefore represents an attractive target for therapeutic intervention. To investigate the primary phenotypes mediated by increased pathway signaling in a clean, patient-relevant context, an act
Externí odkaz:
https://doaj.org/article/64952bf9ee0a4f75af0606c666386285
Autor:
Gabriele Hessler, Creg J. Workman, John E. Goodall, Dario A. A. Vignali, Stephen P. Young, Leigh D Church, David A. Rider, Erich Gulbins, Paul A. Bacon
Publikováno v:
Journal of Leukocyte Biology. 78:266-278
Tumor necrosis factor alpha (TNF-alpha) is a potent, pleiotrophic cytokine, which is proinflammatory but can also suppress T lymphocyte function. In chronic inflammatory disease such as rheumatoid arthritis, exposure of T cells to TNF-alpha alters th
Publikováno v:
FEBS letters. 579(6)
Persistent tumour necrosis factor alpha (TNF-alpha) exposure uncouples proximal T-cell receptor (TCR)-signalling events. Here, we demonstrate that chronic TNF-alpha exposure also attenuates signalling distal to the TCR, by specifically inhibiting Ca2