Zobrazeno 1 - 10
of 10
pro vyhledávání: '"John E Atkinson"'
Autor:
Akihiro Okada, Julien Dugal-Tessier, Maria-Christina Malinao, Brian A. Mendelsohn, John E Atkinson, Banmeet Anand, Josh Snyder
Publikováno v:
Molecular pharmaceutics. 15(6)
AGS62P1 is an antibody drug conjugate (ADC) composed of a human IgG1κ monoclonal antibody against FLT3 (FMS-like tyrosine kinase 3) with a p-acetyl phenylalanine (pAF) residue inserted at position 124 of each heavy chain linked to the proprietary mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1372f3e24e4dc019e557049158afe79d
https://pubmed.ncbi.nlm.nih.gov/29757653
https://pubmed.ncbi.nlm.nih.gov/29757653
Publikováno v:
Journal of applied toxicology : JAT. 14(2)
Exposure to anticholinesterase pesticides has been associated with the development of ocular toxicity in humans and animals, ranging from blurred vision to degeneration of the optic nerve. Based on the concern for human safety, the US Environmental P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac44e239e845c512199798e4dbe33e2e
https://pubmed.ncbi.nlm.nih.gov/8027510
https://pubmed.ncbi.nlm.nih.gov/8027510
Publikováno v:
Life Sciences. 33:577-584
Male rats were exposed to freshly generated cigarette smoke once daily, 5 times a week for 10 weeks. Inhalation of smoke was verified by elevated carboxyhemoglobin in blood sampled immediately after smoke exposure and by increased lung aryl hydrocarb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc8c66714e238de28ed4365c59bed77
https://doi.org/10.1016/0024-3205(83)90133-9
https://doi.org/10.1016/0024-3205(83)90133-9
Publikováno v:
Toxicology and Applied Pharmacology. 81:91-99
Previous work in our laboratory has shown that the continuous administration of α-difluoromethylornithine (DFMO), a highly specific irreversible inhibitor of ornithine decarboxylase (ODC), which is the rate-limiting enzyme in polyamine biosynthesis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a400b2f412f6482fac87eb39156f0709
https://doi.org/10.1016/0041-008x(85)90124-3
https://doi.org/10.1016/0041-008x(85)90124-3
Publikováno v:
Toxicology. 29:121-129
Adriamycin treatment in vivo or addition to incubation mixtures in vitro inhibits hepatic drug metabolism. It has been suggested that adriamycin-induced membrane lipid peroxidation may be a mechanism responsible for this activity in vitro. To determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a0a2ba3aa83965d69262d7a34176bf
https://doi.org/10.1016/0300-483x(83)90044-6
https://doi.org/10.1016/0300-483x(83)90044-6
Publikováno v:
European Journal of Pharmacology. 75:155-158
In rabbit isolated hearts perfused at constant flow with Krebs-Henseleit solution, prostacyclin (PGI2, 0.1–10.0 ng/heart) evoked dose-dependent reductions in coronary perfusion pressure. The magnitude of PGI2-induced vasodilator responses was augme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b773f5ccb5f2c2412e5b4acaebf4ebd8
https://doi.org/10.1016/0014-2999(81)90077-7
https://doi.org/10.1016/0014-2999(81)90077-7
Publikováno v:
Biochemical Pharmacology. 35:714-716
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239d8ac57342cecf3b2234b16a5b50ab
https://doi.org/10.1016/0006-2952(86)90372-2
https://doi.org/10.1016/0006-2952(86)90372-2
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 62(4)
This study tested the hypothesis that the polyamines, a family of low-molecular-weight organic cations with documented regulatory roles in cell growth and differentiation, are mediators of chronic hypoxia-induced pulmonary vascular remodeling. Relati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f7045072fbd9ef93a50dc34e81be5a
https://pubmed.ncbi.nlm.nih.gov/3110122
https://pubmed.ncbi.nlm.nih.gov/3110122
Autor:
John E. Atkinson, William C. Lubawy
Publikováno v:
Toxicology letters. 18(3)
The pyrrolo(1,4)benzodiazepine antitumor antibiotic, anthramycin, shares a number of toxicities with the widely used anticancer agent adriamycin. We investigated whether acute doses of anthramycin and the structurally related compounds, sibiromycin a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bbff7fa1c48f46359c341ff603dab3
https://pubmed.ncbi.nlm.nih.gov/6689384
https://pubmed.ncbi.nlm.nih.gov/6689384
Publikováno v:
Journal of molecular and cellular cardiology. 17(6)
We have compared and contrasted the actions of (−)isoproterenol and (±) trimetoquinol on rabbit heart preparations. In the presence of either GTP or Gpp[NH]p (guanosine-5′-(β, γ imino)triphosphate), trimetoquinol displayed partial agonist acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4741d6a3a749c22a6dc5ee52479b1c5b
https://pubmed.ncbi.nlm.nih.gov/2991540
https://pubmed.ncbi.nlm.nih.gov/2991540