Zobrazeno 1 - 10
of 77
pro vyhledávání: '"John E, Hale"'
Autor:
Kevin Duffin, Kwan Hui, Donetta Gifford-Moore, Xiao-di Huang, Pamela G Rutherford, Nancy K Jackson, John E Hale, Li-Chun Chio, Eugene Zhen, Richard E Higgs, Shuguang Huang, Chung-Wein Lee, Karen Cox, Eileen McCall, Birong Liao, Kenneth E Gould, Mark Rekhter
Publikováno v:
Biomarker Insights, Vol 3, Pp 147-157 (2008)
Background: Current drug therapy of atherosclerosis is focused on treatment of major risk factors, e.g. hypercholesterolemia while in the future direct disease modification might provide additional benefits. However, development of medicines targetin
Externí odkaz:
https://doaj.org/article/c60e5078af034c7d87387ef96cc610fb
Autor:
Eric M. Graban, Richard W. Vachet, Mahdieh Yazdani, Robert C. Vaughan, Zhiguang Jia, Patanachai Limpikirati, Yongbo Huang, John E. Hale, Mark Hazelbaker
Publikováno v:
mAbs. 11:463-476
Monoclonal antibodies are among the fastest growing therapeutics in the pharmaceutical industry. Detecting higher-order structure changes of antibodies upon storage or mishandling, however, is a challenging problem. In this study, we describe the use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e16351ece930067fecb4cd0054c0d6
https://doi.org/10.1080/19420862.2019.1565748
https://doi.org/10.1080/19420862.2019.1565748
Autor:
Birong Liao, Eileen McCall, Karen Cox, Chung-Wein Lee, Shuguang Huang, Richard E Higgs, Li-Chun Chio, Eugene Zhen, John E Hale, Nancy K Jackson, Pamela G Rutherford, Xiao-di Huang, Donetta Gifford-Moore, Kwan Hui, Kevin Duffin, Kenneth E Gould, Mark Rekhter
Publikováno v:
Biomarker Insights, Vol 3 (2008)
Background Current drug therapy of atherosclerosis is focused on treatment of major risk factors, e.g. hypercholesterolemia while in the future direct disease modification might provide additional benefits. However, development of medicines targeting
Externí odkaz:
https://doaj.org/article/77cc1c7dae3b422aab289767ebbbcbd2
Autor:
Jesus A. Gutierrez, Jill A. Dorocke, Michael D. Knierman, Valentina Gelfanova, Richard E. Higgs, Nicholas Lewin Koh, John E. Hale
Publikováno v:
BioTechniques, Vol 38, Iss 6S, Pp S13-S17 (2005)
A method is described for the quantitative determination of peptides using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Known limitations imposed by crystal heterogeneity, peptide ionization differences, d
Externí odkaz:
https://doaj.org/article/c188424f3ff64d8880612dd82bdf71b6
Investigating Therapeutic Protein Structure with Diethylpyrocarbonate Labeling and Mass Spectrometry
Autor:
Richard W. Vachet, Robert C. Vaughan, Nicholas B. Borotto, John E. Hale, Stephen R. Hollingsworth, Eric M. Graban, Yuping Zhou
Publikováno v:
Analytical Chemistry. 87:10627-10634
Protein therapeutics are rapidly transforming the pharmaceutical industry. Unlike for small molecule therapeutics, current technologies are challenged to provide the rapid, high resolution analyses of protein higher order structures needed to ensure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8cdc0c45fef665f8450081f5bd66c3b
https://doi.org/10.1021/acs.analchem.5b03180
https://doi.org/10.1021/acs.analchem.5b03180
Autor:
Jesus A. Gutierrez, Valentina Gelfanova, Robert W. Siegel, Richard E. Higgs, Chloe N. Poston, Michael D. Knierman, John E. Hale, Jinsam You
Publikováno v:
Journal of the American Society for Mass Spectrometry. 25:1228-1236
De novo sequencing by mass spectrometry (MS) allows for the determination of the complete amino acid (AA) sequence of a given protein based on the mass difference of detected ions from MS/MS fragmentation spectra. The technique relies on obtaining sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d27c03d273853c7e629371a72edd3eb
https://doi.org/10.1007/s13361-014-0892-1
https://doi.org/10.1007/s13361-014-0892-1
Autor:
Laura J. Bloem, Chaitanya Saxena, Tabetha M. Bonacci, John E. Hale, Richard E. Higgs, Karen L. Huss
Publikováno v:
Journal of Proteome Research. 8:3951-3957
Recently we have described the development of an Immuno-chemo-proteomics method for drug target deconvolution and profiling the toxicity of known drugs ( Saxena , C. ; Zhen , E. ; Higgs , R. E. ; Hale , J. E. J. Proteome Res. 2008, 8 , 3490 - 3497 ).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190a7abd1e5adf2a6b40421d7612c42c
https://doi.org/10.1021/pr900277x
https://doi.org/10.1021/pr900277x
Publikováno v:
Expert Opinion on Drug Discovery. 4:701-714
Current drug discovery organizations have renewed interest in phenotypic/function based screening for the identification of novel small-molecule drug candidates. Phenotypic screening faces the challenge of deconvoluting the identity of molecular targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c83af19354cd05b265d0d3e6879a9f
https://doi.org/10.1517/17460440903005565
https://doi.org/10.1517/17460440903005565
Autor:
Valentina Gelfanova, Jesse M. Hunter, Kelly R. Bales, Steven M. Paul, Suizhen Lin, Lingzhi Zhao, Feng Liu, John E. Hale, Deanna Koger, Cynthia DeLong
Publikováno v:
The Journal of Neuroscience. 29:3603-3612
Recent studies suggest that bone marrow-derived macrophages can effectively reduce β-amyloid (Aβ) deposition in brain. To further elucidate the mechanisms by which macrophages degrade Aβ, we cultured murine macrophages on top of Aβ plaque-bearing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad0f060d8638c2eac91792079bca68d
https://doi.org/10.1523/jneurosci.5302-08.2009
https://doi.org/10.1523/jneurosci.5302-08.2009
Autor:
John E. Hale, Jude E. Onyia, Shuang Luo, Michael D. Knierman, Derrick R. Witcher, Jesus A. Gutierrez, Jill A. Willency, Douglas Perkins, Zhaoyan Jin, Patricia J. Solenberg
Publikováno v:
Proceedings of the National Academy of Sciences. 105:6320-6325
The peptide hormone ghrelin is the only known protein modified with an O-linked octanoyl side group, which occurs on its third serine residue. This modification is crucial for ghrelin's physiological effects including regulation of feeding, adiposity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9cc40168f9313ca683000dd37b4d9d3
https://doi.org/10.1073/pnas.0800708105
https://doi.org/10.1073/pnas.0800708105