Zobrazeno 1 - 10
of 30
pro vyhledávání: '"John Dulos"'
Autor:
L. Charlotte J. de Bree, Renoud J. Marijnissen, Junda M. Kel, Sietske K. Rosendahl Huber, Peter Aaby, Christine Stabell Benn, Marcel V. W. Wijnands, Dimitri A. Diavatopoulos, Reinout van Crevel, Leo A. B. Joosten, Mihai G. Netea, John Dulos
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Externí odkaz:
https://doaj.org/article/7f8678b8cd804c5489ae3fcebda8bf59
Autor:
L. Charlotte J. de Bree, Renoud J. Marijnissen, Junda M. Kel, Sietske K. Rosendahl Huber, Peter Aaby, Christine Stabell Benn, Marcel V. W. Wijnands, Dimitri A. Diavatopoulos, Reinout van Crevel, Leo A. B. Joosten, Mihai G. Netea, John Dulos
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Avian influenza A of the subtype H7N9 has been responsible for almost 1,600 confirmed human infections and more than 600 deaths since its first outbreak in 2013. Although sustained human-to-human transmission has not been reported yet, further adapta
Externí odkaz:
https://doaj.org/article/7a86a7e49a1b4fd5a94f8b6ec52de8d7
Autor:
Renoud J Marijnissen, Marije I Koenders, Frank L van de Veerdonk, John Dulos, Mihai G Netea, Annemieke M H Boots, Leo A B Joosten, Wim B van den Berg
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38889 (2012)
BACKGROUND: Fungal components have been shown very effective in generating Th17 responses. We investigated whether exposure to a minute amount of C. albicans in the arthritic joint altered the local cytokine environment, leading to enhanced Th17 expa
Externí odkaz:
https://doaj.org/article/316b7997de0f4851b00502ead88500f3
Autor:
Laurence Fayadat-Dilman, Christine Andrews, Gulesi Ayanoglu, Liming Liu, Robert A. Kastelein, Aarron T. Willingham, Sabine Le Saux, Svetlana Sadekova, Dan Malashock, Hans van Eenennaam, Sophie Li, Ying Yu, Soonmo Peter Kang, Beth Hutchins, Andrea van Elsas, John Dulos, Rene De Waal Malefyt, Julie Lee, Frederique M. Poulet, Gregory J. Carven, Constance Cullen, Gary C. Starling, Mark Hsieh, Danuta J. Herzyk, Michel Streuli, Mark A. McCoy, George Soder
Publikováno v:
Molecular Cancer Therapeutics. 19:1298-1307
The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint, which may be engaged by cells in the tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®, MK-3475) is a potent and highly sel
Autor:
Andrea van Elsas, John Dulos, Chirag Acharya, Phillip A Hsieh, Paul G. Richardson, Nikhil C. Munshi, Yu-Tzu Tai, Tengteng Yu, Shih-Feng Cho, Kenneth Wen, Lijie Xing, Kenneth C. Anderson, Liang Lin
Publikováno v:
Leukemia
We investigate here how APRIL impacts immune regulatory T cells and directly contributes to the immunosuppressive multiple myeloma (MM) bone marrow (BM) microenvironment. First, APRIL receptor TACI expression is significantly higher in regulatory T c
Autor:
Beth, Hutchins, Gary C, Starling, Mark A, McCoy, Danuta, Herzyk, Frederique M, Poulet, John, Dulos, Liming, Liu, Soonmo Peter, Kang, Laurence, Fayadat-Dilman, Mark, Hsieh, Christine L, Andrews, Gulesi, Ayanoglu, Constance, Cullen, Rene de Waal, Malefyt, Robert A, Kastelein, Sabine Le, Saux, Julie, Lee, Sophie, Li, Dan, Malashock, Svetlana, Sadekova, George, Soder, Hans, van Eenennaam, Aarron, Willingham, Ying, Yu, Michel, Streuli, Gregory J, Carven, Andrea, van Elsas
Publikováno v:
Molecular cancer therapeutics. 19(6)
The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint, which may be engaged by cells in the tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®, MK-3475) is a potent and highly sel
Autor:
Guido van de Wiel, Shih-Feng Cho, Bonny Lejeune, Kenneth Wen, Liang Lin, Lijie Xing, Paul G. Richardson, Peter van Zandvoort, Lars Guelen, Nikhil C. Munshi, Jos van de Crommert, Yu-Tzu Tai, Tengteng Yu, Kenneth C. Anderson, Phillip A Hsieh, Hans van Eenennaam, Andrea van Elsas, John Dulos, Hamid Namini
Publikováno v:
Blood. 132:3209-3209
A proliferation inducing ligand (APRIL) is a natural ligand with higher affinity than BAFF for both B cell maturation antigen (BCMA) and transmembrane activator and CAML interactor (TACI), which are overexpressed on multiple myeloma (MM) cells. APRIL
Autor:
Maurice Habraken, Yu-Tzu Tai, Jeroen Bakker, Hans van Eenennaam, Andrea van Elsas, John Dulos, Paul Vink
Publikováno v:
Blood. 132:1908-1908
A proliferation-inducing ligand (APRIL) is produced by multiple accessory and myeloid cells in the bone marrow niche. Through binding to its receptors B-cell maturation antigen (BCMA) and transmembrane activator and CAML interactor (TACI), APRIL play
Autor:
Renoud J. Marijnissen, Marije I. Koenders, Annemieke M. H. Boots, Shahla Abdollahi-Roodsaz, John Dulos, Leo A. B. Joosten, Wim B. van den Berg, Fons A. J. van de Loo, Franco Di Padova
Publikováno v:
Arthritis and Rheumatism, 64, 6, pp. 1762-70
ARTHRITIS AND RHEUMATISM, 64(6), 1762-1770. John Wiley and Sons Inc.
Arthritis and Rheumatism, 64, 1762-70
ARTHRITIS AND RHEUMATISM, 64(6), 1762-1770. John Wiley and Sons Inc.
Arthritis and Rheumatism, 64, 1762-70
Item does not contain fulltext OBJECTIVE: To provide an intermediate step between classic arthritis models and clinical trials, the rheumatoid arthritis (RA) synovium SCID mouse model is a valuable tool for use during preclinical research. We underto
Autor:
Peter van Zandvoort, Nitya Nair, Lilian Driessen, Eduard de Cock, Britta Randlev, Jos van de Crommert, Jeroen Elassaiss Schaap, Andrea van Elsas, John Dulos, Hans van Eenennaam
Publikováno v:
Cancer Research. 78:3780-3780
APRIL critically triggers BCMA to drive proliferation and survival of human multiple myeloma (MM) cells. Importantly, APRIL induces resistance to lenalidomide, bortezomib and other standard-of-care drugs. Furthermore, APRIL drives expression of PD-L1