Zobrazeno 1 - 10
of 300
pro vyhledávání: '"John Drago"'
Autor:
Christa Dang, Nawaf Yassi, Karra D. Harrington, Ying Xia, Yen Ying Lim, David Ames, Simon M. Laws, Martha Hickey, Stephanie Rainey‐Smith, Hamid R. Sohrabi, James D. Doecke, Jurgen Fripp, Olivier Salvado, Peter J. Snyder, Michael Weinborn, Victor L. Villemagne, Christopher C. Rowe, Colin L. Masters, Paul Maruff, AIBL Research Group, Brian Chambers, Edmond Chiu, Roger Clarnette, David Darby, Mary Davison, John Drago, Peter Drysdale, Jacqueline Gilbert, Kwang Lim, Nicola Lautenschlager, Dina LoGiudice, Peter McCardle, Steve McFarlane, Alastair Mander, John Merory, Daniel O'Connor, Ron Scholes, Mathew Samuel, Darshan Trivedi, Michael Woodward
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 566-575 (2019)
Abstract Introduction Superior cognitive performance in older adults may reflect underlying resistance to age‐associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it re
Externí odkaz:
https://doaj.org/article/44e63d9842264e76a3274899b66644cb
Autor:
Luning Jiang, Claire O'Leary, Hyun Ah. Kim, Clare L. Parish, Jim Massalas, John L. Waddington, Michelle E. Ehrlich, Günter Schütz, Ilse Gantois, Andrew J. Lawrence, John Drago
Publikováno v:
Neurobiology of Disease, Vol 76, Iss , Pp 137-158 (2015)
D1-dopamine receptors (Drd1a) are highly expressed in the deep layers of the cerebral cortex and the striatum. A number of human diseases such as Huntington disease and schizophrenia are known to have cortical pathology involving dopamine receptor ex
Externí odkaz:
https://doaj.org/article/1f2f0dfe13cb475e8a4e7413475e7a71
Autor:
Hyun Ah. Kim, Luning Jiang, Heather Madsen, Clare L. Parish, Jim Massalas, Arthur Smardencas, Claire O'Leary, Ilse Gantois, Colm O'Tuathaigh, John L. Waddington, Michelle E. Ehrlich, Andrew J. Lawrence, John Drago
Publikováno v:
Neurobiology of Disease, Vol 62, Iss , Pp 323-337 (2014)
Progressive cell loss is observed in the striatum, cerebral cortex, thalamus, hypothalamus, subthalamic nucleus and hippocampus in Huntington disease. In the striatum, dopamine-responsive medium spiny neurons are preferentially lost. Clinical feature
Externí odkaz:
https://doaj.org/article/c6fd7c069bfa449db29cdd2b48a137c5
THE THERAPEUTIC POTENTIAL OF IVERMECTIN FOR COVID-19: A SYSTEMATIC REVIEW OF MECHANISMS AND EVIDENCE
Introduction: Ivermectin is a commonly used antihelminthic agent with over 35 years of established safety data in humans. Recent data demonstrates antiviral activity in vitro against SARS-CoV-2, in addition to a range of viruses. In vitro and animal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb879e20101e74d0400366a5ca7f92e6
https://doi.org/10.22541/au.164864379.98768131/v1
https://doi.org/10.22541/au.164864379.98768131/v1
Autor:
Daniela Babovic, Luning Jiang, Satoshi Goto, Ilse Gantois, Günter Schütz, Andrew J. Lawrence, John L. Waddington, John Drago
Publikováno v:
Journal of Pharmacological Sciences, Vol 121, Iss 1, Pp 39-47 (2013)
Considerable topographic overlap exists between brain opioidergic and dopaminergic neurons. Pharmacological blockade of the dopamine D1 receptor (Drd1a) reverses several behavioural phenomena elicited by opioids. The present study examines the effect
Externí odkaz:
https://doaj.org/article/27b01a8dd3ee465f81565a807fca6f0e
Autor:
Ahmed H. Albariqi, Yuncheng Wang, Rachel Yoon Kyung Chang, Diana H. Quan, Xiaonan Wang, Stefanie Kalfas, John Drago, Warwick J. Britton, Hak-Kim Chan
Publikováno v:
International journal of pharmaceutics. 619
Pharmacokinetic limitations associated with oral ivermectin may limit its success as a potential COVID-19 treatment based on in vitro experiments which demonstrate antiviral efficacy against SARS-CoV-2 at high concentrations. Targeted delivery to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d825d64aa4110865a726ad4dca5146
https://pubmed.ncbi.nlm.nih.gov/35314278
https://pubmed.ncbi.nlm.nih.gov/35314278
Autor:
Ahmed H. Albariqi, Wei-Ren Ke, Dipesh Khanal, Stefanie Kalfas, Patricia Tang, Warwick J Britton, John Drago, Hak-Kim Chan
biBackground:/i/bIvermectin has received worldwide attention as a potential COVID-19 treatment after showing antiviral activity against SARS-CoV-2iin vitro./iHowever, the pharmacokinetic limitations associated with oral administration have been postu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a7eb6fcd04bc0758dadda6301ac929
https://hdl.handle.net/2123/28304
https://hdl.handle.net/2123/28304
Publikováno v:
Journal of Pharmacological Sciences, Vol 119, Iss 4, Pp 297-301 (2012)
Among numerous mechanisms implicated in the regulation of orofacial movements, dopamine-containing neurons have received the most extensive study. Here we review the effects of a) constitutive knockout of D1–5 dopamine receptors and b) conditional
Externí odkaz:
https://doaj.org/article/44ca2ec129cd4394b921a08caf500648
THE THERAPEUTIC POTENTIAL OF IVERMECTIN FOR COVID-19: A SYSTEMATIC REVIEW OF MECHANISMS AND EVIDENCE
IntroductionIvermectin is a commonly used antihelminthic agent with over 35 years of established safety data in humans. Recent data demonstrates antiviral activity in vitro against SARS-CoV-2, in addition to a range of viruses. In vitro and animal mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c831fc309e41bf622b2876f479e7f9d
https://doi.org/10.1101/2020.11.30.20236570
https://doi.org/10.1101/2020.11.30.20236570
Publikováno v:
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA. 30(2)
A new CR TKA design with concave medial and convex lateral tibial polyethylene bearing components was introduced recently to improve functional outcomes. This study aimed to investigate in-vivo articular contact kinematics in unilateral asymmetrical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3cc9a59bded136e2e44995dc29c199
https://pubmed.ncbi.nlm.nih.gov/33388940
https://pubmed.ncbi.nlm.nih.gov/33388940