Zobrazeno 1 - 10
of 22
pro vyhledávání: '"John Douhan"'
Autor:
Brian Juba, Robert Hughes, Mihir D. Parikh, Erin McCarthy, John I. Trujillo, John Robert Springer, Li Xing, Venkataraman Thanabal, Kyung-Hee Kim, Arthur J. Wittwer, Daniel P. Walker, Dean Messing, Nancy L. Wood, Margaret L. Grapperhaus, Nicole Caspers, Zhao-Kui Wan, John Douhan, Shashi Mohan, Mark E. Schnute, Seungil Han, Stephen E. Benoit, Jeffrey F. Ohren, Ingrid P. Buchler, Shaun R. Selness, Thomas N. O'Connell, Jane M. Withka, Michelle Schmidt, Joy S. Miyashiro, Christoph W. Zapf, Nelson Huang, Erica Liu, Rajeev Hotchandani
Publikováno v:
ACS medicinal chemistry letters. 10(1)
[Image: see text] Potent covalent inhibitors of Bruton’s tyrosine kinase (BTK) based on an aminopyrazole carboxamide scaffold have been identified. Compared to acrylamide-based covalent reactive groups leading to irreversible protein adducts, cyana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07c11f4a26356814edcf89f088b8087
https://pubmed.ncbi.nlm.nih.gov/30655951
https://pubmed.ncbi.nlm.nih.gov/30655951
Autor:
Cheryl Nickerson-Nutter, Dean Messing, Nilufer P. Seth, Sean Keegan, John Douhan, Jason Edmonds, Timothy A. Cook, Stephen E. Benoit, Andrew L. Rankin, Varenka Rodriguez, Sarah Du, Micah J. Benson, Melanie Ruzek, Mark E. Schnute, Kyri Dunussi-Joannopoulos, David von Schack
Publikováno v:
The Journal of Immunology. 193:185-197
Inhibitors of Bruton’s tyrosine kinase (BTK) possess much promise for the treatment of oncologic and autoimmune indications. However, our current knowledge of the role of BTK in immune competence has been gathered in the context of genetic inactiva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e370ef582270e05a47f654d5c540f0
https://doi.org/10.4049/jimmunol.1302570
https://doi.org/10.4049/jimmunol.1302570
Autor:
John Charles Kath, Theodore O. Johnson, Landon R. Whitby, Benjamin F. Cravatt, Baoxian Wei, Chu Wang, Mark E. Schnute, Melissa M. Dix, Lee R. Roberts, Laurence O. Whiteley, Adam M. Gilbert, Jonathan J. Hulce, Sherry Niessen, Erik C. Hett, Chris Joslyn, Matthew Merrill Hayward, Bryan R. Lanning, John Douhan
Publikováno v:
Nature chemical biology
Kinases are principal components of signal transduction pathways and the focus of intense basic and drug discovery research. Irreversible inhibitors that covalently modify non-catalytic cysteines in kinase active-sites have emerged as valuable probes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4cc4677878a633174a0e1621180667
http://europepmc.org/articles/PMC4138289
http://europepmc.org/articles/PMC4138289
Autor:
Bruce L. Homer, Shashi K. Ramaiah, Sean Keegan, Cheryl Nickerson-Nutter, Joy S. Miyashiro, Stephen E. Benoit, Tatyana Andreyeva, Jameel Syed, Nagappan Mathialagan, Shashi Mohan, Nancy L. Wood, Jason Edmonds, Mark E. Schnute, Andrew L. Rankin, Elena Peeva, Yutian Zhan, Kyri Dunussi-Joannopoulos, Dean Messing, Timothy A. Cook, Micah J. Benson, John Douhan, Nilufer P. Seth
Publikováno v:
The Journal of Immunology. 191:4540-4550
Autoantibody production and immune complex deposition within the kidney promote renal disease in patients with lupus nephritis. Thus, therapeutics that inhibit these pathways may be efficacious in the treatment of systemic lupus erythematosus. Bruton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d254f70707f6dc81ca363e845e897d96
https://doi.org/10.4049/jimmunol.1301553
https://doi.org/10.4049/jimmunol.1301553
Autor:
Paul W. Wu, John Douhan, Xiaochuan Zhou, Mary Collins, Joy S. Miyashiro, Kyriaki Dunussi-Joannopoulos, Derek C. Cole
Publikováno v:
ASSAY and Drug Development Technologies. 5:751-758
Bruton's tyrosine kinase (Btk) and interleukin-2-inducible T cell kinase (Itk) are members of the TEC family of nonreceptor tyrosine kinases and are expressed primarily in B and T cells, respectively. Both kinases are critically involved in lymphocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c4deca0b582bd41dd881dce39c9a81f
https://doi.org/10.1089/adt.2007.093
https://doi.org/10.1089/adt.2007.093
Publikováno v:
The Journal of Experimental Medicine
Patients with one type of major histocompatibility complex class II combined immunodeficiency have mutations in a gene termed class II transactivator (CIITA), which coordinately controls the transcription of the three major human class II genes, HLA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e3f0538d2614cd64f7ea7b29ae222b
https://doi.org/10.1084/jem.185.11.1885
https://doi.org/10.1084/jem.185.11.1885
Publikováno v:
The Journal of Experimental Medicine
Major histocompatibility complex (MHC) class II combined immunodeficiency (CID), also known as type II bare lymphocyte syndrome, is an autosomal recessive genetic disorder characterized by the complete lack of expression of MHC class II antigens. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e850b292623c0bf89fecadcdecc8404
https://doi.org/10.1084/jem.183.3.1063
https://doi.org/10.1084/jem.183.3.1063
Publikováno v:
International Immunology. 8:255-265
We have examined the expression and regulation of the MHC class II E beta d gene in both cell lines and in transgenic mice. In transient transfection assays, as little as 192 bp of the E beta d proximal promoter was sufficient to direct constitutive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dc4122f89ada4ab062f99b2dadd13c7
https://doi.org/10.1093/intimm/8.2.255
https://doi.org/10.1093/intimm/8.2.255
Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells
Autor:
Joy S. Miyashiro, Stephen E. Benoit, Sean Keegan, Matthew J. Whitters, Hilda E. Ramon, Mark Ryan, Heath Guay, John Douhan, Mary Collins, Kyri Dunussi-Joannopoulos, Timothy P. LaBranche, Yijun Carrier, Quintus G. Medley
Publikováno v:
European journal of immunology. 42(6)
The glucocorticoid-induced TNFR-related (GITR) protein is a coactivating receptor that is constitutively expressed on Treg cells and induced on activated T cells. To better under-stand the role of long-term GITR signaling, we generated a mouse that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cabb49f3804c8e88f0469534d7d0da17
https://pubmed.ncbi.nlm.nih.gov/22678896
https://pubmed.ncbi.nlm.nih.gov/22678896
Autor:
Miguel A. Gonzalez-Gay, Laurie H. Glimcher, Marie M. Griffiths, Chella S. David, Eric Zanelli, Harvinder S. Luthra, Michael J. Bull, Gerald H. Nabozny, John Douhan
Publikováno v:
The Journal of Experimental Medicine
Collagen-induced arthritis (CIA) is an animal model of autoimmune inflammatory polyarthritis that has features similar to rheumatoid arthritis (RA). Much like RA, susceptibility to mouse CIA is influenced by the major histocompatibility complex (MHC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28efc905140c8f8ee122fffaec5a87d6
http://europepmc.org/articles/PMC2191685
http://europepmc.org/articles/PMC2191685