Zobrazeno 1 - 10
of 10
pro vyhledávání: '"John Devany"'
SummaryCell proliferation is a central process in tissue development, homeostasis and disease. Yet how proliferation is regulated in the tissue context remains poorly understood. Here, we introduce a quantitative framework to elucidate how tissue gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1d2a4bb0e3dfb5e51a4a94f3692565
https://doi.org/10.1101/2022.07.04.498508
https://doi.org/10.1101/2022.07.04.498508
Publikováno v:
Journal of Cell Biology. 221
Although implicated in adhesion, only a few studies address how the actin assembly factors guide cell positioning in multicellular tissues. The formin, Dia1, localizes to the proliferative basal layer of the epidermis. In organotypic cultures, Dia1 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0490afb63ad91094295c0f955fee1ee7
https://doi.org/10.1083/jcb.202101008
https://doi.org/10.1083/jcb.202101008
Although implicated in adhesion, few studies address how actin assembly factors guide cell positioning in multicellular tissue. The formin, Dia1, localizes to the proliferative basal layer of epidermis. In organotypic cultures, Dia1 depletion reduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc08ede82da80e082f8f1d39952b7970
https://doi.org/10.1101/2021.01.04.425231
https://doi.org/10.1101/2021.01.04.425231
Autor:
Akira, Imamoto, Sewon, Ki, Leiming, Li, Kazunari, Iwamoto, Venkat, Maruthamuthu, John, Devany, Ocean, Lu, Tomomi, Kanazawa, Suxiang, Zhang, Takuji, Yamada, Akiyoshi, Hirayama, Shinji, Fukuda, Yutaka, Suzuki, Mariko, Okada
Publikováno v:
Life Science Alliance
This study presents evidence that CRK/CRKL and TBX1 may share pathways that participate in organogenesis affected in DiGeorge syndrome (22q11.2DS) via global control of gene expression and metabolism
CRK and CRKL (CRK-like) encode adapter protei
CRK and CRKL (CRK-like) encode adapter protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::afd0db09aa564cfd57bedf4819b39e60
https://pubmed.ncbi.nlm.nih.gov/32041892
https://pubmed.ncbi.nlm.nih.gov/32041892
Epithelia have distinct cellular architectures, which are established in development, re-established after wounding, and maintained during tissue homeostasis despite cell turnover and mechanical perturbations. In turn, cell shape also controls tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3478c49f903ff46107514901578e7d92
https://doi.org/10.1101/804294
https://doi.org/10.1101/804294
Autor:
Aneesh T. Veetil, Kavya Smitha Pillai, Yamuna Krishnan, Anand Saminathan, Michael Schwake, John Devany
The role of membrane potential in most intracellular organelles remains unexplored because of the lack of suitable probes. We describe a DNA-based fluorescent reporter that quantitates membrane potential and can be targeted to specific organelles in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25d0335527535cea35d0b2db2eabb5cd
https://doi.org/10.1101/523019
https://doi.org/10.1101/523019
Autor:
Anand Saminathan, Kasturi Chakraborty, Nagarjun Narayanaswamy, Yamuna Krishnan, John Devany, Elizabeth Zeichner, Ka-Ho Leung
It is extremely challenging to quantitate lumenal Ca(2+) in acidic Ca(2+) stores of the cell because all Ca(2+) indicators are pH sensitive, and Ca(2+) transport coupled to pH in acidic organelles. We have developed a fluorescent DNA-based reporter,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa6850182a9319a05694380b32a4d2f0
https://europepmc.org/articles/PMC7107693/
https://europepmc.org/articles/PMC7107693/
Autor:
Mariko Okada, Kazunari Iwamoto, Suxiang Zhang, Takuji Yamada, Akira Imamoto, Shinji Fukuda, Venkat Maruthamuthu, Ocean Lu, Sewon Ki, Leiming Li, Yutaka Suzuki, Tomomi Kanazawa, Akiyoshi Hirayama, John Devany
Publikováno v:
Life Science Alliance. 3:e201900635
CRKandCRKL(CRK-like) encode adapter proteins with similar biochemical properties. Here, we show that a 50% reduction of the family-combined dosage generates developmental defects, including aspects of DiGeorge/del22q11 syndrome in mice. Like the mous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9a26371ac6d0976a91c1560aedc358d
https://doi.org/10.26508/lsa.201900635
https://doi.org/10.26508/lsa.201900635
Publikováno v:
Nano letters. 18(2)
We describe a new method to measure viscosity within subcellular organelles of a living cell using nanorheology. We demonstrate proof of concept by measuring viscosity in lysosomes in multiple cell types and disease models. The lysosome is an organel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de7c4c484119089686166aeedb56f8e
https://pubmed.ncbi.nlm.nih.gov/29313356
https://pubmed.ncbi.nlm.nih.gov/29313356
Autor:
Yamuna Krishnan, Kasturi Chakraborty, Nagarjun Narayanaswamy, John Devany, Ka-Ho Leung, Elizabeth Zeichner, Anand Saminathan
Publikováno v:
Nature Methods. 16:205-205
The originally published paper has been updated to include the following new reference, added as ref. 18: Albrecht, T., Zhao, Y., Nguyen, T. H., Campbell, R. E. & Johnson, J. D. Fluorescent biosensors illuminate calcium levels within defined beta-cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::809f21518719a85f5cd5aa4da0bdc00e
https://doi.org/10.1038/s41592-019-0309-y
https://doi.org/10.1038/s41592-019-0309-y