Zobrazeno 1 - 2
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pro vyhledávání: '"John Darnow"'
Autor:
A.R. Disanto, Thomas J. Hochadel, Richard J. Morales, Jeffrey S. Barrett, John Darnow, Shashank Rohatagi, Albert J. Azzaro, Sara K. Watson, Kimberly E. DeWitt
Publikováno v:
The Journal of Clinical Pharmacology. 37:238-247
Orally administered selegiline hydrochloride is a selective monoamine oxidase type B inhibitor at the recommended regimen of 10 mg/day, but it loses selectivity at higher doses. In bypassing first-pass metabolism, a 24-hour application of transdermal
Autor:
Jeffrey S. Barrett, Lee J. McDonald, Esther M. Morris, Anthony R. DiSanto, John Darnow, Shashank Rohatagi
Publikováno v:
Pharmaceutical Research. 14:50-55
Purpose. A Selegiline Transdermal System (STS) is under development for indications which may not be optimally or safely treated with oral selegiline. Studies were conducted to evaluate the in vitro penetration and skin metabolism of selegiline in or