Zobrazeno 1 - 10
of 20
pro vyhledávání: '"John D.H. Stead"'
Autor:
Kathryn L. Hilde, Peter Blandino, John D.H. Stead, Huzefa Khalil, Robert C. Thompson, Pamela M. Maras, Stanley J. Watson, Cigdem Aydin, Isabelle Birt, Alex Stefanov, Megan Hastings Hagenauer, David Goldman, Zhifeng Zhou, Elaine K. Hebda-Bauer, Fan Meng, Huda Akil, Sarah M. Clinton
Publikováno v:
Biol Psychiatry
Background For more than 16 years, we have selectively bred rats for either high or low levels of exploratory activity within a novel environment. These bred high-responder (bHR) and bred low-responder (bLR) rats model temperamental extremes, exhibit
Autor:
John D.H. Stead, Isabelle Birt, Robert C. Thompson, Huzefa Khalil, Stanley J. Watson, Cigdem Aydin, Elaine K. Hebda-Bauer, Pamela M. Maras, Peter Blandino, Zhifeng Zhou, Megan Hastings Hagenauer, Alex Stefanov, Kathryn L. Hilde, David Goldman, Sarah M. Clinton, Huda Akil, Fan Meng
BackgroundFor over 16 years, we have selectively bred rats to show either high or low levels of exploratory activity within a novel environment. These “bred High Responder” (bHR) and “bred Low Responder” (bLR) rats serve as a model for temper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8d5cb71c4417fb6bc2ccb1b1a6dcfc
Autor:
Francois Charih, Amanda Van Geel, Gianfilippo Coppola, James R. Green, Stephanie Simard, Natalina Salmaso, Gareth M. Rurak, John D.H. Stead, Barbara Woodside
Astroglial cells are emerging as key players in the development and homeostatic maintenance of neurons and neuronal networks. Astroglial cell functions are critical to neuronal migration and maturation, myelination, and synapse dynamics, however litt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0220ac79bd8371d4d5f22d5084accb61
https://doi.org/10.1101/681684
https://doi.org/10.1101/681684
Publikováno v:
Journal of Gambling Studies
Unfortunately, only a small percent of pathological gamblers seek the professional help they need. In the current study, we test the idea that individual differences in reward sensitivity should predict whether a pathological gambler has sought treat
Autor:
Abas Jama, Susan M. Miller, Delia M. Vazquez, Sarah M. Clinton, Charles R. Neal, Stanley J. Watson, Huda Akil, John D.H. Stead, Johanna Schneider
Publikováno v:
Behavior Genetics. 36:697-712
Outbred Sprague-Dawley rats can be classified as high responders (HR) or low responders (LR) based on their levels of exploratory locomotion in a novel environment. While this novelty-seeking dimension was originally related to differential vulnerabi
Autor:
Charles R. Neal, Delia M. Vazquez, Stanley J. Watson, Yongjia Wang, Simon J. Evans, John D.H. Stead, Fan Meng, Huda Akil
Publikováno v:
The Journal of Neuroscience. 26:345-353
Neural development involves the expression of ensembles of regulatory genes that control the coordinate and region-specific expression of a host of other genes, resulting in the unique structure, connectivity, and function of each brain region. Altho
Autor:
Edward G. Jones, D. M. Walsh, William E. Bunney, Fan Meng, Juan F. Lopez, Hiroaki Tomita, Simon J. Evans, Richard M. Myers, John D.H. Stead, Huda Akil, Robert C. Thompson, Jun Li, S.J. Watson, Marquis P. Vawter, Charles R. Neal, Prabhakara V. Choudary
Publikováno v:
Proceedings of the National Academy of Sciences. 101:15506-15511
In this report we describe findings that imply dysregulation of several fibroblast growth factor (FGF) system transcripts in frontal cortical regions of brains from human subjects with major depressive disorder (MDD). This altered gene expression was
Publikováno v:
Genome Research. 13:2101-2111
The insulin minisatellite (INS VNTR) has been intensively analyzed due to its associations with diseases including diabetes. We have previously used patterns of variant repeat distribution in the minisatellite to demonstrate that genetic diversity is
Autor:
John D.H. Stead, Alec J. Jeffreys
Publikováno v:
The American Journal of Human Genetics. 71:1273-1284
The insulin minisatellite (INS VNTR) associates with susceptibility to a variety of diseases. We have developed a high-resolution system for analyzing variant repeat distributions applicable to all known minisatellite alleles, irrespective of size, w
Autor:
Alec J. Jeffreys, John D.H. Stead
Publikováno v:
Human Molecular Genetics. 9:713-723
Previous analysis of germline mutation at highly unstable GC-rich minisatellites with continuous allele size distributions revealed similar meiotic recombinational mechanisms operating at all loci investigated. The insulin minisatellite has been stud