Zobrazeno 1 - 10
of 45
pro vyhledávání: '"John D. Tange"'
Autor:
David J. P. Ferguson, John D. Tange, George K. Radda, Zoltan H. Endre, Peter J. Ratcliffe, J. G. G. Ledingham
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
ResearcherID
Europe PubMed Central
ResearcherID
1. The distribution of morphological injury was assessed qualitatively and quantitatively in the perfused rat kidney in vitro at controlled rates of oxygen delivery in the presence of low concentrations of erythrocytes. 2. In control kidneys (total o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2f0df195751b4c4299706b2b0b5bd6
https://ora.ox.ac.uk/objects/uuid:59276846-2461-4d69-8a5f-39b5ff92fe68
https://ora.ox.ac.uk/objects/uuid:59276846-2461-4d69-8a5f-39b5ff92fe68
Autor:
Peter J. Harris, Lesley L. Walker, Sandford L. Skinner, John D. Tange, Mark A. Henry, Robert J. Naughton
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 17:613-626
SUMMARY 1. The p-aminophenol (pAP) model of tubular necrosis displays elevated tubular pressures equivalent to ‘stop-flow’, with low glomerular filtration rate (GFR) but maintained blood flow and urine output. Renal function, micropuncture, and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e466bd94e5988bcd09e73bd77f6a4c
https://doi.org/10.1111/j.1440-1681.1990.tb01362.x
https://doi.org/10.1111/j.1440-1681.1990.tb01362.x
Publikováno v:
Pathology. 15:75-81
A model of crescentic glomerulonephritis in the rat was developed, based upon an augmented form of nephrotoxic nephritis. The glomerular lesions were relatively mild, permitting an analysis of the morphologic events in crescent formation to an extent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33df22cba7d7cdc899b2902f67cfbdad
https://doi.org/10.3109/00313028309061406
https://doi.org/10.3109/00313028309061406
Publikováno v:
Pathology. 19:143-149
In rats, single intravenous doses of folic acid induce damage to renal tubular epithelium, deposition of folic acid in tubular lumens, increase in wet kidney weight, oliguria and interstitial connective tissue proliferation. Separation of the nephrot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9172e09c8a2287b4363017ec455825
https://doi.org/10.3109/00313028709077125
https://doi.org/10.3109/00313028709077125
Publikováno v:
Kidney International. 18:562-570
Renal metabolism of drugs and their effects on tubular function depend on the entry of the drug into specific renal cells. In turn, this depends on differential regional blood flow and the relative rates of delivery of the drug to luminal and contral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc83a9d13e7d8c831ede4efd4da2023
https://doi.org/10.1038/ki.1980.174
https://doi.org/10.1038/ki.1980.174
Autor:
John D. Tange, Mark A. Henry
Publikováno v:
Pathology. 14:355-361
Deposition of bilirubin at the tip of the renal papilla has been studied in the infant homozygous Gunn rat. the deposits form during the 4th wk of life in ground substance along basement membranes of capillaries and tubules and along the borders of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ff8f67e7bf42875b5a1c3ca3e94801
https://doi.org/10.3109/00313028209092110
https://doi.org/10.3109/00313028209092110
Publikováno v:
Xenobiotica. 11:579-587
1. At a perfusate concn. of 3.5-4.0 mM, 59 plus or minus 9 nmol of paracetamol h per g wet wt. were oxidized by isolated rat kidney. 2. Approx. half the paracetamol undergoing oxidation was converted to a mercapturic acid metabolite and the remainder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e0594ee0fa2ed9617482de30a0ac26
https://doi.org/10.3109/00498258109045869
https://doi.org/10.3109/00498258109045869
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 7:203-222
Urinary paracetamol metabolites from Sprague-Dawley and Wistar rats were analysed by reversed-phase HPLC. Variations in the metabolic profile were observed as a function of dose, age, sex, species and route of administration. In addition the effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f0a058fbe3cd74738fa1db67973861
https://doi.org/10.1007/bf03189567
https://doi.org/10.1007/bf03189567
Autor:
John D. Tange, D. J. Davies
Publikováno v:
The Journal of Pathology. 137:305-314
The severity of the renal papillary necrosis produced in rats by ethylenimine is dependent both on dose and urinary concentration within the medulla. When this is reduced by diuresis, the severity of the lesion is effectively reduced. Increasing urin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50319c6954fd460af8a1994629a9112c
https://doi.org/10.1002/path.1711370405
https://doi.org/10.1002/path.1711370405
Autor:
John D. Tange, K. R. Emslie, Ronald S. Sweet, John Davis, Sandford L. Skinner, Robert J. Naughton, Lesley L. Walker
Publikováno v:
Kidney International. 24:740-747
Early functional and morphological changes in renal tubular necrosis due to p-aminophenol. Functional and morphological changes developed rapidly in rats after the intravenous administration of the organic nephrotoxin p-aminophenol. Proximal intratub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa069ac8d8c077ba47c51301f2d5291
https://doi.org/10.1038/ki.1983.221
https://doi.org/10.1038/ki.1983.221