Zobrazeno 1 - 10
of 36
pro vyhledávání: '"John D. Schatzle"'
Autor:
Pablo Engel, Jill M. Westcott, Chunyan Ma, Wilson Castro, Ninghai Wang, Silvia Calpe, Cox Terhorst, John D. Schatzle
Publikováno v:
The Journal of Immunology. 185:5683-5687
EWS/FLI1-activated transcript 2 (EAT-2)A and EAT-2B are single SH2-domain proteins, which bind to phosphorylated tyrosines of signaling lymphocyte activation molecule family receptors in murine NK cells. While EAT-2 is a positive regulator in human c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eee3526791b62fef2ee71ed2a69d033
https://doi.org/10.4049/jimmunol.1001974
https://doi.org/10.4049/jimmunol.1001974
Publikováno v:
Current Opinion in Immunology. 18:656-664
The signaling lymphocyte activation molecule (SLAM) family of receptors and their associated signaling adaptors play a pivotal role in the regulation of various stages of cellular immunity. They regulate lymphocyte-lymphocyte interactions involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f5045695c2f596a5afaf1eaa9e3f28
https://doi.org/10.1016/j.coi.2006.09.010
https://doi.org/10.1016/j.coi.2006.09.010
Autor:
Edward K. Wakeland, Charles Nguyen, Mei Yan, Madhavi Bhaskarabhatla, Chandra Mohan, Liunan Li, Kirthi Kumar, Angela B. Mobley, John D. Schatzle, Jill M. Mooney
Publikováno v:
Science. 312:1665-1669
The susceptibility locus for the autoimmune disease lupus on murine chromosome 1,Sle1z/Sle1bz, and the orthologous human locus are associated with production of autoantibody to chromatin. We report that the presence ofSle1z/Sle1bzimpairs B cell anerg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f071f7e1e05ac56f7b93f980017fa45c
https://doi.org/10.1126/science.1125893
https://doi.org/10.1126/science.1125893
Autor:
Porunelloor A. Mathew, Kyung Mi Lee, Vinay Kumar, John D. Schatzle, Susan E. Stepp, Michael F Bennett, Megan E. McNerney
Publikováno v:
The Journal of Experimental Medicine
Natural killer (NK) cells are critical in the immune response to tumor cells, virally infected cells, and bone marrow allografts. 2B4 (CD244) is expressed on all NK cells and the ligand for 2B4, CD48, is expressed on hematopoietic cells. Cross-linkin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0057f80d99c2ba71d5bce535c559a6
https://doi.org/10.1084/jem.20031989
https://doi.org/10.1084/jem.20031989
Autor:
Elena Koulich, Margaret A. Morris, Michael B. Bennett, Vinay Kumar, John D. Schatzle, Veera Arora, Jingxuan Liu, Thaddeus C. George
Publikováno v:
Transplantation. 74:1449-1454
Background. Natural killer (NK) cells use inhibitory Ly49 receptors to differentiate self from foreign cells based on interactions with major histocompatibility (MHC) class I molecules. Inhibitory receptors may recognize multiple MHC class I molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::575d25db1882cd30b6e4a06efe56b59a
https://doi.org/10.1097/00007890-200211270-00018
https://doi.org/10.1097/00007890-200211270-00018
Autor:
Christoph Wülfing, Michael D. Sjaastad, Nigel J. Burroughs, Irina Tskvitaria-Fuller, John D. Schatzle, Jennifer Klem
Publikováno v:
Immunological Reviews. 189:64-83
Cellular interaction is vital to the activation of most lymphocytes. At the interface between the lymphocyte and the cell that activates it, multiple receptor/ligand pairs accumulate in distinct patterns. This accumulation is intriguing, as it is lik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9b8dee0391b697a78286e86c7f921d0
https://doi.org/10.1034/j.1600-065x.2002.18907.x
https://doi.org/10.1034/j.1600-065x.2002.18907.x
Autor:
Veera Arora, Michael V. L. Bennett, Vinay Kumar, Jingxuan Liu, John D. Schatzle, Margaret A. Morris, Thaddeus C. George, Jennifer Klem
Publikováno v:
The Journal of Immunology. 169:3661-3666
Inhibitory Ly49 receptors expressed on NK cells provide a mechanism for tolerance to normal self tissues. The immunoregulatory tyrosine-based inhibitory motifs present in some Ly49s are able to transmit an inhibitory signal upon ligation by MHC class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803cfd754dc493fd8ff25659f5a9afe8
https://doi.org/10.4049/jimmunol.169.7.3661
https://doi.org/10.4049/jimmunol.169.7.3661
Publikováno v:
The Journal of Immunology. 169:55-62
2B4 is a receptor belonging to the Ig superfamily and is found on all murine NK cells as well as a small subset of T cells. Previous studies have found that cross-linking of the 2B4 receptor results in both increased cytotoxicity and IFN-γ secretion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72dc0907f6377f1fb457dd52bcd0ffda
https://doi.org/10.4049/jimmunol.169.1.55
https://doi.org/10.4049/jimmunol.169.1.55
Publikováno v:
European Journal of Immunology. 29:2392-2399
The NK cell receptor 2B4 is expressed on the surface of all murine NK cells and a subset of T cells. Ligation of 2B4 with monoclonal antibodies increases target cell lysis and IFN-γ production. 2B4 is the high-affinity counter-receptor for CD48 in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95a22e611a132a7244230311678ebb33
https://doi.org/10.1002/(sici)1521-4141(199908)29:08<2392::aid-immu2392>3.0.co
https://doi.org/10.1002/(sici)1521-4141(199908)29:08<2392::aid-immu2392>3.0.co
Autor:
Susan E. Stepp, John D. Schatzle, Porunelloor A. Mathew, Shane Sheu, Vinay Kumar, Michael J. Bennett
Publikováno v:
Proceedings of the National Academy of Sciences. 96:3870-3875
The receptor 2B4 belongs to the Ig superfamily and is found on the surface of all murine natural killer (NK) cells as well as T cells displaying non-MHC-restricted cytotoxicity. Previous studies have suggested that 2B4 is an activating molecule becau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e840b18723b8b83bd968cd866074fd2
https://doi.org/10.1073/pnas.96.7.3870
https://doi.org/10.1073/pnas.96.7.3870