Zobrazeno 1 - 10
of 32
pro vyhledávání: '"John D. Prugh"'
Autor:
G. R. Sitko, Robert J. Gould, S. Lee Gaul, Guixiang Zhang, John D. Prugh, Bohumil Bednar, Maria T. Stranieri, Rodney A. Bednar, Marie A. Holahan, Jacquelynn J. Cook, George D. Hartman, R. J. Lynch
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:865-870
Centrally constrained thieno[2,3- b ]thiophene sulfonamides have provided a potent, selective, orally active series of platelet aggregation inhibitors. Compound 21 showed excellent activity in the dog after a single oral dose of 200 μg/kg.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0f8de86bc7089713bb925b1864d70c7
https://doi.org/10.1016/s0960-894x(97)00120-0
https://doi.org/10.1016/s0960-894x(97)00120-0
Autor:
Stuart R. Michelson, M. F. Sugrue, John D. Prugh, Murcko Mark A, B. M. Mckeever, J. P. Springer, H. Schwam, R. L. Smith, George D. Hartman, J. M. Sondey, Pierre Mallorga
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5c5dfdcd331eda8460cba5f1379aa39
https://doi.org/10.1002/chin.199146306
https://doi.org/10.1002/chin.199146306
Publikováno v:
ChemInform. 24
A simple method for chemically differentiating primary and secondary amines is described in which the primary amine is condensed with benzaldehyde to form an imine leaving the secondary amine available to be protected with BOC. The imine is then hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::796d7f78fbca03c42f2237404a5f1eea
https://doi.org/10.1002/chin.199309088
https://doi.org/10.1002/chin.199309088
Autor:
Rodney A. Bednar, R. J. Lynch, Guixiang Zhang, G. R. Sitko, Robert J. Gould, Maria T. Stranieri, George D. Hartman, Bohumil Bednar, Marie A. Holahan, Stanley L. Gaul, Jacquelynn J. Cook, John D. Prugh
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40c4f773705aa4039e316dbbb5c0ba2c
https://doi.org/10.1002/chin.199734121
https://doi.org/10.1002/chin.199734121
Publikováno v:
Synthetic Communications. 22:2357-2360
A simple method for chemically differentiating primary and secondary amines is described in which the primary amine is condensed with benzaldehyde to form an imine leaving the secondary amine available to be protected with BOC. The imine is then hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5299dc2fd359d7164f58b2adf57c234f
https://doi.org/10.1080/00397919208019091
https://doi.org/10.1080/00397919208019091
Autor:
Harvey Schwam, John M. Sondey, Robert L. Smith, B. M. Mckeever, Michelson, James P. Springer, Pierre Mallorga, Murcko Mark A, George D. Hartman, John D. Prugh
Publikováno v:
Journal of Medicinal Chemistry. 34:1805-1818
A series of 5-substituted thieno[2,3-b]- and thieno[3,2-b)- and thieno[3,2-b)thiophene-2-sulfonamides was prepared and evaluated for topical ocular hypotensive activity in glaucoma models. The 5-substituents were varied to maximize both inhibitory po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b999cc942df6d9a360ce4ed63b7052
https://doi.org/10.1021/jm00110a008
https://doi.org/10.1021/jm00110a008
Publikováno v:
Journal of Heterocyclic Chemistry. 27:679-682
An efficient synthetic route is reported for the preparation of thieno[2,3-e]furan-2-sulfonamides bearing oxygenated functionality at C-5. The method employs conversion of furan-3-carboxaldehyde to an intermediate that, in the key step, undergoes fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9481863e4480d5f2a4d7e69846f7a214
https://doi.org/10.1002/jhet.5570270336
https://doi.org/10.1002/jhet.5570270336
Autor:
John H. Hutchinson, Melissa S. Egbertson, Nathan C. Ihle, Ben C. Askew, Wasyl Halczenko, Bohumil Bednar, Mark E. Duggan, Robert J. Gould, John S. Wai, Rodney A. Bednar, George D. Hartman, Karen M. Brashear, John D. Prugh, Thorsten E. Fisher, Michael J. Breslin
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(17)
Compound affinity for activated and resting GPIIb/IIIa receptors may differ, and comparison of those differences determines selectivity. Structural features that influence selectivity are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44441041c5da843884ee0f431d14c463
https://pubmed.ncbi.nlm.nih.gov/10987423
https://pubmed.ncbi.nlm.nih.gov/10987423
Autor:
John D. Prugh, Robert L. Smith, W. C. Randall, Harvey Schwam, Michael F. Sugrue, Stuart R. Michelson, John M. Sondey, Pierre Mallorga, Wasyl Halczenko, George D. Hartman
Publikováno v:
Journal of medicinal chemistry. 35(16)
Novel 5-[(alkylamino)methyl]thieno[2,3-b]furan-2-sulfonamides were prepared and evaluated in vitro for inhibition of human carbonic anhydrase II (CA II) and ex vivo for their ability to inhibit Ca II in the albino rabbit eye after topical administrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f02c926028954a9eb9b0b37de670bd6
https://pubmed.ncbi.nlm.nih.gov/1501230
https://pubmed.ncbi.nlm.nih.gov/1501230
Publikováno v:
ChemInform. 21
An efficient synthetic route is reported for the preparation of thieno[2,3-e]furan-2-sulfonamides bearing oxygenated functionality at C-5. The method employs conversion of furan-3-carboxaldehyde to an intermediate that, in the key step, undergoes fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afb0d34280ce78af6006b7d9fb2b3afa
https://doi.org/10.1002/chin.199036164
https://doi.org/10.1002/chin.199036164