Zobrazeno 1 - 10
of 267
pro vyhledávání: '"John D. Mountz"'
Lupus nephritis correlates with B cell interferon-β, anti-Smith, and anti-DNA: a retrospective study
Autor:
Fatima Alduraibi, Huma Fatima, Jennie A. Hamilton, W. Winn. Chatham, Hui-Chen Hsu, John D. Mountz
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-11 (2022)
Abstract Background In systemic lupus erythematosus (SLE), detection of interferon-β (IFNβ) in B cells was found to be most prominent in patients with high anti-Smith (Sm) and renal disease, but a mechanistic connection was not clear. The objective
Externí odkaz:
https://doaj.org/article/57428646da2e43a58aca30a8fe32a805
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss Suppl 2 (2024)
Externí odkaz:
https://doaj.org/article/bbbf90b091224932932b330c613db1be
Publikováno v:
Lupus Science and Medicine, Vol 9, Iss Suppl 3 (2022)
Externí odkaz:
https://doaj.org/article/b8b9faed3c5a48a887cec8251b19aab9
Publikováno v:
The Journal of Immunology. 209:1513-1522
Activated naive (aNAV) B cells have been shown to be the precursor of the CD11c+T-bet+ IgD−CD27− double-negative (DN)2 or atypical memory (aMEM) B cells in systemic lupus erythematosus (SLE). To determine factors that maintain resting naive (rNAV
Publikováno v:
Lupus 21st Century 2022.
Autor:
John D. Mountz, Min Gao, David M. Ponder, Shanrun Liu, Chiao-Wang Sun, Fatima Alduraibi, Kathryn Sullivan, Betty Pat, Louis J. Dell'Italia, Hui-Chen Hsu
Publikováno v:
Clinical immunology (Orlando, Fla.). 244
Here, we report a case of atopic dermatitis (AD) in a patient who received biweekly doses of dupilumab, an antibody against the IL-4 receptor α chain (IL-4Rα). Single cell RNA-sequencing showed that naïve B cells expressed the highest levels of IL
Publikováno v:
Clinical Immunology. 247:109239
Objective: To determine if circulating autoantibodies (autoAbs) and T-helper cell cytokines correlate with a different class of lupus nephritis (LN), including class III/IV, compared to class V and other manifestations of systemic lupus erythematosus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b5090340bbb3d6caa37e4ae3c216fd0
https://doi.org/10.21203/rs.3.rs-1539371/v1
https://doi.org/10.21203/rs.3.rs-1539371/v1
Autor:
Jeremy B. Foote, Hui-Chen Hsu, Trenton R. Schoeb, Charles O. Elson, David Ponder, Huixian Hong, John D. Mountz, Huma Fatima, Casey D. Morrow, Fatima Alduraibi, Wayne Duck
Publikováno v:
Arthritis Rheumatol
To determine the extent to which the gut microbiome influences systemic autoimmunity in a mouse model of lupus.We generated germ-free (GF) lupus-prone BXD2 mice, which under normal conditions develop spontaneous germinal centers (GCs) and high titers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2865e6bd4052915ff56a18dc87c9c983
https://europepmc.org/articles/PMC9071869/
https://europepmc.org/articles/PMC9071869/
Autor:
PingAr Yang, Jake Y. Chen, Peter D. Burrows, Shanrun Liu, Huixian Hong, John D. Mountz, Hui-Chen Hsu, Min Gao, Qi Wu, Hao Li, Daniel J. Cua
Publikováno v:
J Immunol
IL-23 promotes autoimmune disease, including Th17 CD4 T cell development and autoantibody production. In this study, we show that a deficiency of the p19 component of IL-23 in the autoimmune BXD2 (BXD2-p19−/−) mouse leads to a shift of the follic