Zobrazeno 1 - 10
of 62
pro vyhledávání: '"John D. Mcneish"'
Autor:
Anna C. Liang, Emiri T. Mandeville, Takakuni Maki, Akihiro Shindo, Angel T. Som, Naohiro Egawa, Kanako Itoh, Tsu Tshen Chuang, John D. Mcneish, Julie C. Holder, Josephine Lok, Eng H. Lo, Ken Arai
Publikováno v:
Cell Transplantation, Vol 25 (2016)
Aging and vascular comorbidities such as hypertension comprise critical cofactors that influence how the brain responds to stroke. Ischemic stress induces neurogenesis and oligodendrogenesis in younger brains. However, it remains unclear whether thes
Externí odkaz:
https://doaj.org/article/7f922247b54b4e03869f0a5b1867d9c6
Novel pancreatic endocrine maturation pathways identified by genomic profiling and causal reasoning.
Autor:
Alex Gutteridge, J Michael Rukstalis, Daniel Ziemek, Mark Tié, Lin Ji, Rebeca Ramos-Zayas, Nancy A Nardone, Lisa D Norquay, Martin B Brenner, Kim Tang, John D McNeish, Rebecca K Rowntree
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56024 (2013)
We have used a previously unavailable model of pancreatic development, derived in vitro from human embryonic stem cells, to capture a time-course of gene, miRNA and histone modification levels in pancreatic endocrine cells. We investigated whether it
Externí odkaz:
https://doaj.org/article/ba50e4e5722448bd92405c4304f6ca70
Autor:
Gabriel Nistor, Monica M Siegenthaler, Stephane N Poirier, Sharyn Rossi, Aleksandra J Poole, Maura E Charlton, John D McNeish, Chris N Airriess, Hans S Keirstead
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20692 (2011)
The availability of human neuronal progenitors (hNPs) in high purity would greatly facilitate neuronal drug discovery and developmental studies, as well as cell replacement strategies for neurodegenerative diseases and conditions, such as spinal cord
Externí odkaz:
https://doaj.org/article/f5c8ece6d7be47c7b13379dcbfa862a7
Publikováno v:
Cell Stem Cell. 17:8-10
While iPSCs have created unprecedented opportunities for drug discovery, there remains uncertainty concerning the path to the clinic for candidate therapeutics discovered with their use. Here we share lessons that we learned, and believe are generali
Autor:
Takakuni Maki, John D. McNeish, Josephine Lok, Eng H. Lo, Ken Arai, Tsu Tshen Chuang, Akihiro Shindo, Kanako Itoh, Angel T. Som, Anna C. Liang, Julie C. Holder, Naohiro Egawa, Emiri T. Mandeville
Publikováno v:
Cell Transplantation, Vol 25 (2016)
Aging and vascular comorbidities such as hypertension comprise critical cofactors that influence how the brain responds to stroke. Ischemic stress induces neurogenesis and oligodendrogenesis in younger brains. However, it remains unclear whether thes
Autor:
John D. McNeish, Nicholas Atwater, Joel M. Kralj, Graham Dempsey, Adam E. Cohen, Cuong Nguyen, Barry S. Brown, Khuram W. Chaudhary
Publikováno v:
Journal of pharmacological and toxicological methods. 81
Introduction The Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative seeks an in vitro test to accurately predict clinical Torsades de Pointes (TdP). We developed a cardiotoxicity assay incorporating simultaneous measurement of the action po
Autor:
John D. McNeish, Kanako Itoh, Josephine Lok, Julie C. Holder, Anna C. Liang, Takakuni Maki, Akihiro Shindo, Mia C Borlongan, Emiri T. Mandeville, Hidekazu Tomimoto, Naohiro Egawa, Eng H. Lo, Ken Arai, Naoki Itoh, Tsu Tshen Chuang
Publikováno v:
Stroke. 47(4)
Background and Purpose— Pentraxin 3 (PTX3) is released on inflammatory responses in many organs. However, roles of PTX3 in brain are still mostly unknown. Here we asked whether and how PTX3 contributes to blood–brain barrier dysfunction during th
Autor:
Steve L. Stice, Raymond S. Hurst, John E. Hambor, Jacob Bradley Schwarz, Robert J. Mather, John D. McNeish, Laura E. Zawadzke, Justin L Gazard, David W. Machacek, Robert A. Volkmann, Christopher J. O’Donnell, John T. Lazzaro, Marsha L. Roach, Laura Weibley
Publikováno v:
Journal of Biological Chemistry. 285:17209-17217
Stem cell biology offers advantages to investigators seeking to identify new therapeutic molecules. Specifically, stem cells are genetically stable, scalable for molecular screening, and function in cellular assays for drug efficacy and safety. A key
Autor:
Lisa R. Leon, Matthew Boehm, Eun Gyoung Hong, Denise Chen, Min Wu, Amy L. Swift, Mario R. Fernandez, Kurt W. Fisher, Matthias H. Tschöp, Paul T. Pfluger, Oleg V. Chaika, Robert L. Kortum, Aimee Schreiner, Jason K. Kim, Hwi Jin Ko, Michele K. Dougherty, Diane L. Costanzo-Garvey, John Y. Jun, John D. McNeish, Mike Winer, Tina Treece, Deborah K. Morrison, Andrey S. Shaw, Jeffery L. Stock, Deanna J. Volle, Robert E. Lewis
Publikováno v:
Cell Metabolism. 10:366-378
Summary Kinase suppressors of Ras 1 and 2 (KSR1 and KSR2) function as molecular scaffolds to potently regulate the MAP kinases ERK1/2 and affect multiple cell fates. Here we show that KSR2 interacts with and modulates the activity of AMPK. KSR2 regul
Autor:
John D. McNeish
Publikováno v:
Current Opinion in Pharmacology. 7:515-520
All physiologic processes operate in a cellular setting. Therefore, drug discoverers need the highest quality cells as they pursue the next generation of safe and effective medicines. Recently, investigators have begun to consider stem cells as a new