Zobrazeno 1 - 10
of 658
pro vyhledávání: '"John D. Lambris"'
Autor:
Christina Lamers, Xiaoguang Xue, Martin Smieško, Henri van Son, Bea Wagner, Nadja Berger, Georgia Sfyroera, Piet Gros, John D. Lambris, Daniel Ricklin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Therapeutic modulation of the complement system has gained interest over the past two decades. Here, the authors provide molecular-level insight into the mode-of-action, target selectivity and species specificity of the compstatin family of complemen
Externí odkaz:
https://doaj.org/article/0c7331cff4f34721b958795607a6055b
Autor:
Alexandra Gerogianni, Melissa Bal, Camilla Mohlin, Trent M. Woodruff, John D. Lambris, Tom E. Mollnes, Dick J. Sjöström, Per H. Nilsson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Iron oxide nanoparticles (IONPs) are widely used in diagnostic and therapeutic settings. Upon systemic administration, however, they are rapidly recognized by components of innate immunity, which limit their therapeutic capacity and can potentially l
Externí odkaz:
https://doaj.org/article/98f1b9d1f3a24517a729bb9b927be744
Autor:
Robin Schmitz, Zachary W. Fitch, Paul M. Schroder, Ashley Y. Choi, Miriam Manook, Janghoon Yoon, Mingqing Song, John S. Yi, Sanjay Khandelwal, Gowthami M. Arepally, Alton B. Farris, Edimara S. Reis, John D. Lambris, Jean Kwun, Stuart J. Knechtle
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Donor-specific antibodies in sensitized recipients may cause kidney transplant rejection. Here the authors show that complement component C3 inhibition prolongs graft survival by inhibiting T and B cell proliferation/activation and hence tissue injur
Externí odkaz:
https://doaj.org/article/9003312b88304e17b0bd7ab46a8e6ace
Autor:
Andrea Doni, Raffaella Parente, Ilaria Laface, Elena Magrini, Cristina Cunha, Federico Simone Colombo, João F. Lacerda, António Campos, Sarah N. Mapelli, Francesca Petroni, Rémi Porte, Tilo Schorn, Antonio Inforzato, Toine Mercier, Katrien Lagrou, Johan Maertens, John D. Lambris, Barbara Bottazzi, Cecilia Garlanda, Marina Botto, Agostinho Carvalho, Alberto Mantovani
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Serum Amyloid P is a humoral component with established roles in the response to bacterial infection and regulation of tissue remodeling. Here the authors provide evidence to a further crucial role of serum amyloid P in the context of fungal pathogen
Externí odkaz:
https://doaj.org/article/242e6b06db064e1db778527e7d0f6479
Autor:
Thyago Bispo Leonel, Joel José Megale Gabrili, Carla Cristina Squaiella-Baptistão, Trent M. Woodruff, John D. Lambris, Denise V. Tambourgi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The clinical manifestations of envenomation by Bothrops species are complex and characterized by prominent local effects that can progress to tissue loss, physical disability, or amputation. Systemic signs can also occur, such as hemorrhage, coagulop
Externí odkaz:
https://doaj.org/article/d4d0ce99312e44bebecbaeaf558136c0
Autor:
Amelie Kuhn, Jana Riegger, Graciosa Q. Teixeira, Markus Huber-Lang, John D. Lambris, Cornelia Neidlinger-Wilke, Rolf E. Brenner
Publikováno v:
Cells, Vol 12, Iss 6, p 887 (2023)
Terminal complement complex (TCC) deposition was identified in human degenerated discs. To clarify the role of terminal complement activation in disc degeneration (DD), we investigated respective activating mechanisms and cellular effects in annulus
Externí odkaz:
https://doaj.org/article/503a1bd248494d9096c65bd6142d786d
Autor:
Felipe Silva de França, Isadora Maria Villas-Boas, Bruno Cogliati, Trent M. Woodruff, Edimara da Silva Reis, John D. Lambris, Denise V. Tambourgi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Systemic complement activation drives a plethora of pathological conditions, but its role in snake envenoming remains obscure. Here, we explored complement’s contribution to the physiopathogenesis of Naja annulifera envenomation. We found that N. a
Externí odkaz:
https://doaj.org/article/59e4bcfd4c8c4c309229afaedf515dc1
Autor:
Rebecca Halbgebauer, Ebru Karasu, Christian K. Braun, Annette Palmer, Sonja Braumüller, Anke Schultze, Fabian Schäfer, Sarah Bückle, Alica Eigner, Ulrich Wachter, Peter Radermacher, Ranillo R. G. Resuello, Joel V. Tuplano, Kristina Nilsson Ekdahl, Bo Nilsson, Milena Armacki, Alexander Kleger, Thomas Seufferlein, Miriam Kalbitz, Florian Gebhard, John D. Lambris, Martijn van Griensven, Markus Huber-Lang
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Trauma represents a major socioeconomic burden worldwide. After a severe injury, hemorrhagic shock (HS) as a frequent concomitant aspect is a central driver of systemic inflammation and organ damage. The kidney is often strongly affected by traumatic
Externí odkaz:
https://doaj.org/article/2a44a84c5e6546358f4ea9327612f5b9
Autor:
Lucie Colineau, Maisem Laabei, Guanghui Liu, David Ermert, John D. Lambris, Kristian Riesbeck, Anna M. Blom
Publikováno v:
Matrix Biology Plus, Vol 6, Iss , Pp 100020- (2020)
Streptococcus pyogenes is a major human pathogen that causes a variety of diseases ranging from mild skin and throat infections to fatal septicemia. In severe invasive infections, S. pyogenes encounters and interacts with components of the extracellu
Externí odkaz:
https://doaj.org/article/47f6decd72324071a5f89d95d69f6891
Autor:
Inge Baas, Laura Delvasto-Nuñez, Peter Ligthart, Conny Brouwer, Claudia Folman, Edimara S. Reis, Daniel Ricklin, John D. Lambris, Diana Wouters, Masja de Haas, Ilse Jongerius, Sacha S. Zeerleder
Publikováno v:
Haematologica, Vol 105, Iss 2 (2020)
Externí odkaz:
https://doaj.org/article/080d337720a34853a8f979a034075c99