Zobrazeno 1 - 10
of 24
pro vyhledávání: '"John D. Lafferty"'
Autor:
Mark Crowther, John D. Lafferty, Andrew McFarlane, Linda M. Halchuk, Anne Raby, David Barth, Brian L. Sheridan
Publikováno v:
American Journal of Clinical Pathology. 129:309-315
Routine laboratories use a hemoglobin H (HbH) screen to detect alpha-thalassemia carriers of fatal hemoglobin Bart's hydrops fetalis. This test is laborious and has sensitivity concerns. A commercial zeta-globin enzyme-linked immunosorbent assay (ELI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::344d13ce2bfa3b3370cd4ba60bf3e24b
https://doi.org/10.1309/mnpf3xxxvax5nm9h
https://doi.org/10.1309/mnpf3xxxvax5nm9h
Publikováno v:
Laboratory Hematology. 11:185-189
The reticulocyte count reflects the erythropoietic activity of the bone marrow and is thus useful in both the approach to the diagnosis of anemia and in monitoring bone marrow response to therapy. Traditionally, reticulocyte quantitation relied upon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c524b89b74bfa49590f734289e5cc31
https://doi.org/10.1532/lh96.05013
https://doi.org/10.1532/lh96.05013
DOMINANT β-THALASSEMIA DUE TO A NEWLY IDENTIFIED FRAMESHIFT MUTATION IN EXON 3 (CODON 113, GTG → TG)
Publikováno v:
Hemoglobin. 26:83-86
β-Thalassemia (thal) is a common inherited anemia caused by mutations that reduce or abolish expression of β-globin chains required for adult hemoglobin (Hb). Individuals who are heterozygotes for ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b560959e8145c530bd2f55d4ed2a87a
https://doi.org/10.1081/hem-120002945
https://doi.org/10.1081/hem-120002945
Autor:
H. Ewa Witkowska, David H.K. Chui, Margaret F. Patterson, Pimlak Charoenkwan, Fred Lorey, John D. Lafferty, Jerry Z. Finklestein, Barry Eng, John S. Waye
Publikováno v:
British Journal of Haematology. 115:72-78
Haemoglobin H (Hb H) disease is caused by deletion or inactivation of three alpha-globin genes, leaving only one intact and active alpha-globin gene. People with Hb H disease usually have moderate anaemia, but are generally thought to be asymptomatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d07e0463aea3955832840b58a8c10150
https://doi.org/10.1046/j.1365-2141.2001.03080.x
https://doi.org/10.1046/j.1365-2141.2001.03080.x
Publikováno v:
American Journal of Clinical Pathology. 114:927-931
Homozygous (--SEA) alpha zero-thalassemia deletion, the cause of up to 80% of fetal hydrops in Southeast Asia, is encountered in many other countries. Heterozygous carrier rates of the deletion in Southeast Asian populations range from 4% to 14%. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cd8a259497d0b3b208e107f78bd197f
https://doi.org/10.1309/26g7-bqh4-93bv-ur0q
https://doi.org/10.1309/26g7-bqh4-93bv-ur0q
Publikováno v:
Archives of Pathology & Laboratory Medicine. 124:1320-1323
Context.—The differentiation between iron deficiency and a thalassemia syndrome is an important consideration in the investigation of microcytic anemia. Objective.—An established statistical method was used to demonstrate the importance of consid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97404bb73267aff6d468562677e9c07
https://doi.org/10.5858/2000-124-1320-aatait
https://doi.org/10.5858/2000-124-1320-aatait
Publikováno v:
Hemoglobin. 22:373-376
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57bfc2f225b5acb128c73461cc470e71
https://doi.org/10.3109/03630269809071531
https://doi.org/10.3109/03630269809071531
Autor:
K. Matthew, John D. Lafferty, John S. Waye, Barry Eng, Mohammed K. Ali, Margaret F. Patterson
Publikováno v:
Hemoglobin. 19:335-341
A 73-year-old female of Dutch descent was referred for investigation of a high oxygen affinity hemoglobin variant. The beta-globin gene was amplified using the polymerase chain reaction. Direct nucleotide sequencing of the polymerase chain reaction a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d33635cd2720225f165611cbf999571
https://doi.org/10.3109/03630269509005825
https://doi.org/10.3109/03630269509005825
Autor:
John D. Lafferty, Lynda Walker, Lisa M. Nakamura, David H.K. Chui, Margaret F. Patterson, Sui-Li Yong, John S. Waye, John K. Wu, Barry Eng
Publikováno v:
American Journal of Hematology. 74:179-181
We describe a complicated genetic counseling and prenatal diagnostic case involving an East Indian couple that had lost two consecutive pregnancies. Hemoglobinopathy screening was conducted to investigate the possibility of Hb Bart's hydrops fetalis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::752e9b2b9c0029998846bde68c1ae05c
https://doi.org/10.1002/ajh.10423
https://doi.org/10.1002/ajh.10423
Publikováno v:
Clinical and investigative medicine. Medecine clinique et experimentale. 35(3)
Purpose: Preparing bone marrow smears using non-anticoagulated bone marrow aspirate is a traditional practice but many laboratories now use anticoagulated aspirate samples in K-EDTA. There are no published studies comparing the effectiveness of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a56cf7db7e1333ed72f34e094572392
https://pubmed.ncbi.nlm.nih.gov/22673313
https://pubmed.ncbi.nlm.nih.gov/22673313