Zobrazeno 1 - 10
of 55
pro vyhledávání: '"John D. Johnston"'
Autor:
Essam Kerwash, Marija Sajic, Khadija Rerhou Rantell, James W. McBlane, John D. Johnston, Alison Niewiarowska, Andrew S. Butler, Susan Cole
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 8, Pp 8209-8225 (2024)
Sickle cell disease (SCD) and transfusion-dependent β-thalassemia (TDT) are hereditary haemoglobinopathies characterized by a reduction in functional β-globin chains. Both conditions cause tiredness and increase susceptibility to infection, which c
Externí odkaz:
https://doaj.org/article/b7972641d1d14bfaaa73db427cc7211b
Autor:
Essam Kerwash, John D. Johnston
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 906 (2024)
Casgevy (exa-cel) is an autologous cellular therapy modified ex vivo by a CRISPR-Cas9-mediated gene-editing technology. For Casgevy to be granted the indication in transfusion-dependent β-thalassemia, one single-arm trial was submitted which was not
Externí odkaz:
https://doaj.org/article/7abc92f213e64e9bbb69987a9b40a347
Autor:
John D. Johnston, Peter Feldschreiber
Publikováno v:
Therapeutic innovationregulatory science. 48(5)
To obtain a license to be placed on the marketplace, a medicinal product must be accompanied by data on quality and data from preclinical studies and studies of clinical safety and efficacy. At the time of first production, a custom-made medicinal pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49171de95a35dc1742dccf080da1cc9a
https://pubmed.ncbi.nlm.nih.gov/30231439
https://pubmed.ncbi.nlm.nih.gov/30231439
Autor:
John D. Johnston, Peter Feldschreiber
Publikováno v:
British Journal of Clinical Pharmacology. 77:939-946
Current European pharmaceutical legislation is not adequate to meet advances in science and technologies that will lead to rapid development of custom-made medicines. Using existing legislation for custom-made medical devices as a template and anti-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d38e4143e2839a45d6b8e05f1bff71bd
https://doi.org/10.1111/bcp.12250
https://doi.org/10.1111/bcp.12250
Autor:
Peter Feldschreiber, John D. Johnston
Publikováno v:
British Journal of Clinical Pharmacology. 77:421-426
The European pharmaceutical regulatory system has not yet been challenged by issues related to highly personalized medicines such as those to be found with active substances that affect RNA biochemistry. We review the current status of RNA-based phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e65ebb6687edaa1c64e0f62ab85fd69d
https://doi.org/10.1111/bcp.12173
https://doi.org/10.1111/bcp.12173
Autor:
James B. Hadaway, Gene Olczak, Mark Connolly, Joseph Cosentino, Randal Telfer, Tony Whitman, Conrad Wells, J. Scott Knight, John D. Johnston, David Chaney
Publikováno v:
SPIE Proceedings.
The JWST (James Webb Space Telescope) Optical Telescope Element (OTE) consists of a 6.6 meter clear aperture, 18-segment primary mirror, all-reflective, three-mirror anastigmat operating at cryogenic temperatures. To verify performance of the primary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::535e084903a012355f5ce0aab2cf3053
https://doi.org/10.1117/12.2234224
https://doi.org/10.1117/12.2234224
Publikováno v:
Journal of Spacecraft and Rockets. 43:762-770
The development of gossamer space structures such as solar sails and sunshields presents many challenges due to their large size and extreme flexibility. The post-deployment structural geometry exhibited during ground testing may significantly depart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d5b7fad6fc47b5d1c1223f7092674a1
https://doi.org/10.2514/1.14298
https://doi.org/10.2514/1.14298
Publikováno v:
Journal of Spacecraft and Rockets. 39:717-724
Thin-film membrane structures are under consideration for use in many future gossamer spacecraft systems. Examples include sunshields for large aperture telescopes, solar sails, and membrane optics. The development of capabilities for testing and ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81f502b40c7807b84f00fc3ca88220cb
https://doi.org/10.2514/2.3870
https://doi.org/10.2514/2.3870
Autor:
John D. Johnston, Earl A. Thornton
Publikováno v:
Journal of Spacecraft and Rockets. 37:604-613
Thermally induced structural motions are known to affect the attitude dynamics of low Earth orbiting satellites during eclipse transitions. Motions of e exible appendages such as solar panels lead to rigid body rotations of the entire satellite becau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::579d9578dd11f65afe479c09e06e7683
https://doi.org/10.2514/2.3633
https://doi.org/10.2514/2.3633
Autor:
John D. Johnston, Earl A. Thornton
Publikováno v:
Journal of Guidance, Control, and Dynamics. 21:581-587
The performance of a significant number of spacecraft has been impacted negatively by attitude disturbances resulting from thermally induced deformations of flexible appendages. Motions of flexible appendages such as deployable booms and solar arrays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b86365ad8b4072280284542c6d255dd4
https://doi.org/10.2514/2.4297
https://doi.org/10.2514/2.4297