Zobrazeno 1 - 9
of 9
pro vyhledávání: '"John D. Hoekman"'
Publikováno v:
Journal of Pharmaceutical Sciences. 103:2231-2239
Previously, we reported a novel pressurized olfactory drug (POD) delivery device that deposits aerosolized drug preferentially to upper nasal cavity. This POD device provided sustained central nervous system (CNS) levels of soluble morphine analgesic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac13c958f041d5a8067ea65cce246f21
https://doi.org/10.1002/jps.24022
https://doi.org/10.1002/jps.24022
Autor:
William H. Frey, Jared M. Fine, Paula M. Martinez, Leah R. Hanson, Thuhien Nguyen, Jens Pohl, John D. Hoekman, Rachel B. Burns
Publikováno v:
Drug Delivery. 19:149-154
Growth differentiation factor 5 (GDF5), in addition to its role in bone and joint development, protects dopaminergic (DA) neurons from degeneration, and is a potential therapeutic agent for Parkinson's disease. Its large size and insolubility at phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550374dc8b7ec4e1e37eee97ecee58d5
https://doi.org/10.3109/10717544.2012.657720
https://doi.org/10.3109/10717544.2012.657720
Autor:
Rodney J. Y. Ho, John D. Hoekman
Publikováno v:
Anesthesia & Analgesia. 113:641-651
Background Centrally acting opioid analgesics such as morphine and fentanyl are effective, but their efficacy is often limited by a delayed response or side effects resulting from systemic first pass before reaching the brain and the central nervous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e874f6f03f2568632a8f66c78ba38ea
https://doi.org/10.1213/ane.0b013e3182239b8c
https://doi.org/10.1213/ane.0b013e3182239b8c
Autor:
John D. Hoekman, Rodney J. Y. Ho
Publikováno v:
AAPS PharmSciTech. 12:534-543
Many nasally applied compounds gain access to the brain and the central nervous system (CNS) with varying degree. Direct nose-to-brain access is believed to be achieved through nervous connections which travel from the CNS across the cribriform plate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8f85764b3096e95c04d92b1f0c5df2
https://doi.org/10.1208/s12249-011-9614-1
https://doi.org/10.1208/s12249-011-9614-1
Publikováno v:
The Protein Journal. 25:175-182
The Homology module within Insight-II was used to model residues 374-420, sequences missing in the coordinates of resolved structure of the catalytic subunit of calcineurin. The modeling was done in two segments. The calmodulin binding region from re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7133db1ed59765b2e6520c7051b7d83
https://doi.org/10.1007/s10930-006-9000-0
https://doi.org/10.1007/s10930-006-9000-0
Publikováno v:
Protein Science. 14:1151-1157
Using immunological approaches and mass spectrometry, five proteins associated with metallothionein-3 in mouse brains have been identified. Metallothionein-3 and associated proteins were isolated using immunoaffinity chromatography over immobilized a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8066bb1e45ca63c94e888294f9606d
https://doi.org/10.1110/ps.041113005
https://doi.org/10.1110/ps.041113005
Autor:
Jeff Stevenson, Kenneth R. Maravilla, Shanrong Zhang, Tot Bui, John D. Hoekman, Rodney J. Y. Ho
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 9 (2010)
PLoS ONE, Vol 5, Iss 9 (2010)
Background: Gadolinium (Gd), with its 7 unpaired electrons in 4f orbitals that provide a very large magnetic moment, is proven to be among the best agents for contrast enhanced MRI. Unfortunately, the most potent MR contrast agent based on Gd require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8876e540796f21d8642b77a639b5b2bc
http://europepmc.org/articles/PMC2948015
http://europepmc.org/articles/PMC2948015
Autor:
Rachel B. Matthews, William H. Frey, Reshma J. Rao, Donald C. Sweet, Dianne L. Marti, Leah R. Hanson, Annina Roeytenberg, Paula M. Martinez, S. Scott Panter, Valerie G. Coppes, John D. Hoekman
Deferoxamine (DFO) is a high-affinity iron chelator approved by the Food and Drug Administration for treating iron overload. Preclinical research suggests that systemically administered DFO prevents and treats ischemic stroke damage and intracerebral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51bf914f7814f54516bef2e93786343
https://europepmc.org/articles/PMC2729791/
https://europepmc.org/articles/PMC2729791/
Autor:
Lynn Pulliam, William H. Frey, Paula M. Martinez, Bing Sun, Hans Rempel, Leah R. Hanson, John D. Hoekman, Reshma J. Rao
Publikováno v:
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2(1)
Intranasal (IN) delivery of HIV-1 Tat in aging mice was investigated as a possible model for HIV-1 infection in the brain. After IN administration, the distribution of [(125)I]-labeled Tat in the brains of Swiss Webster mice was evaluated by autoradi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe2a2a569ee038a73f7c10eb0148deb3
https://pubmed.ncbi.nlm.nih.gov/18040830
https://pubmed.ncbi.nlm.nih.gov/18040830