Zobrazeno 1 - 10
of 72
pro vyhledávání: '"John D. Hildebrandt"'
Publikováno v:
Encyclopedia of Biological Chemistry III ISBN: 9780128220405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0775294785a806d4887b4b8ce6a30663
https://doi.org/10.1016/b978-0-12-819460-7.00208-5
https://doi.org/10.1016/b978-0-12-819460-7.00208-5
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 365:219-225
Ser54 of G(s)α binds guanine nucleotide and Mg(2+) as part of a conserved sequence motif in GTP binding proteins. Mutating the homologous residue in small and heterotrimeric G proteins generates dominant-negative proteins, but by protein-specific me
Autor:
Daniel R. Knapp, Michael D. Wilcox, Kevin L. Schey, Lana A. Cook, John D. Hildebrandt, Troy Nelson, Jane Dingus, Rebecca Ettling
Publikováno v:
Molecular & Cellular Proteomics. 5:671-685
We characterized the variable processing of the G protein gamma subunit isoforms associated with bovine brain G proteins, a primary mediator of cellular communication. Ggamma subunits were isolated from purified brain G proteins and characterized by
Autor:
John D. Hildebrandt, Wanling Yang
Publikováno v:
Cellular Signalling. 18:194-201
Analysis of the genomic sequences, cDNAs and expressed sequence tags (ESTs) in human and mouse for the 12 genes of the gamma subunits of the heterotrimeric G proteins has allowed us to identify the common versus unique elements of the organization an
Autor:
John D. Hildebrandt
Publikováno v:
Molecular Pharmacology. 69:1079-1082
G protein-coupled receptor (GPCR)-Galpha fusion proteins were first characterized more than 10 years ago as a strategy for studying receptor-G protein signaling. A large number of studies have used this approach to characterize receptor coupling to m
Autor:
Christopher A. Wells, Lia H. Campbell, Kathryn Robinson, John D. Hildebrandt, Jane Dingus, John H. Cleator
Publikováno v:
Biochemistry. 44:11882-11890
The Gβ and Gγ subunit of the heterotrimeric G proteins form a functional dimer that is stable once assembled in vivo or in vitro. The requirements, mechanism, and specificity of dimer formation are still incompletely understood, but represent impor
Publikováno v:
Pharmacogenetics. 14:741-747
The alpha subunit of the heterotrimeric G protein Gs (Gsalpha) is involved in numerous physiological processes and is a primary determinant of cellular responses to extracellular signals. Genetic variations in the Gsalpha gene may play an important r
Publikováno v:
Journal of Biological Chemistry. 279:36601-36607
A Ser to Asn mutation at position 54 of the alpha subunit of G(s) (designated N54-alpha(s)) was characterized after transient expression of it with various components of the receptor-adenylyl cyclase pathway in COS-1, COS-7, and HEK 293 cells. Previo
Publikováno v:
Proceedings of the National Academy of Sciences. 100:5081-5086
Heterotrimeric G proteins transduce signals from activated transmembrane G protein-coupled receptors to appropriate downstream effectors within cells. Signaling specificity is achieved in part by the specific α, β, and γ subunits that compose a gi
Publikováno v:
Journal of Neurochemistry. 73:633-640
The distribution and properties in brain of the alpha subunits of the major bovine brain Go isoforms, GoA, GoB and GoC, were characterized. The alpha(o)A and alpha(o)B isoforms arise from alternative splicing of RNAs from a single alpha(o) gene, wher