Zobrazeno 1 - 10
of 27
pro vyhledávání: '"John D. Graef"'
Autor:
Richard Lieberman, Khaled Elnaggar, Kimberly Jesseman, Sarah DeFrancisco, Kelsey Degouveia, Emma Suneby, Hao Wu, L. Alejandro Rojas, John D. Graef
Synucleinopathies such as Parkinson’s disease (PD) are characterized by pathologic production, aggregation, and cell-to-cell transmission of α-synuclein (α-syn) protein that results in impaired cellular function. While neurons of the substantia n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1991b7f4bfd1f1d1e5b7f1cb738c34f8
https://doi.org/10.1101/2022.11.15.516591
https://doi.org/10.1101/2022.11.15.516591
Autor:
Carolyn Diane Dzierba, Debra J. Post-Munson, Ronald J. Knox, Lorin A. Thompson, Shuya Wang, Matthew G. Soars, Michele Matchett, Linda J. Bristow, James Herrington, Clotilde Bourin, Amy Newton, Rick L. Pieschl, Eric Shields, Amy Easton, Kathy Mosure, Guanglin Luo, Kimberly Newberry, Ling Chen, John D. Graef, Arun K. Senapati, Nicholas A. Meanwell, Digavalli V. Sivarao
Publikováno v:
Journal of Medicinal Chemistry. 62:831-856
3-Aryl-indole and 3-aryl-indazole derivatives were identified as potent and selective Nav1.7 inhibitors. Compound 29 was shown to be efficacious in the mouse formalin assay and also reduced complete Freund’s adjuvant (CFA)-induced thermal hyperalge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8738aee38a77abf37b839d8d841c0ca8
https://doi.org/10.1021/acs.jmedchem.8b01550
https://doi.org/10.1021/acs.jmedchem.8b01550
Autor:
null John D. Graef, null Hao Wu, null Carrie Ng, null Chicheng Sun, null Vivian Villegas, null Deena Qadir, null Kimberly Jesseman, null Stephen T. Warren, null Rudolf Jaenisch, null Angela Cacace, null Owen Wallace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::118daa63193f3a96231f4c56a9a75db4
https://doi.org/10.1111/ejn.14660/v3/response1
https://doi.org/10.1111/ejn.14660/v3/response1
Autor:
Mahesh Paschapur, Jeffrey M. Brown, Tanmaya Bastia, Lawrence R. Marcin, Jayakumar Sankara Warrier, Srinivasan Thangathirupathy, Joanne J. Bronson, Raja Reddy Kallem, Huiping Zhang, Jyoti Gulia, Alda Fernandes, Digavalli V. Sivarao, Deborah Keavy, Amy Newton, Jianqing Li, Pattipati S. Naidu, Kuchibhotla Vijaya Kumar, James Kempson, Michael R. Weed, Rick L. Pieschl, Mark Bookbinder, Charlie F. Albright, Kimberly Newberry, Yu-Wen Li, Dalton King, Manjunath Ramarao, Jean Simmermacher, Linda J. Bristow, Meenakshee Sinha, Eric Shields, Lorin A. Thompson, John E. Macor, Charulatha Sanmathi, Imadul Islam, B.N. Srikumar, Richard E. Olson, John D. Graef, Arvind Mathur, Narasimharaju Kalidindi, Joseph Polino, Michael Sinz, Thaddeus F. Molski, Jayant Aher, Reeba K. Vikramadithyan
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 363:377-393
(R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169) and the phosphate prodrug 4-((3S,4S)-3-fluoro-1-((R)-1-(4-methylbenzyl)-2-oxopyrrolidin-3-yl)piperidin-4-yl)phenyl dihydrogen phosphate (BMS-98
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fc12be7607ec5d5401f625fdca24cd2
https://doi.org/10.1124/jpet.117.242784
https://doi.org/10.1124/jpet.117.242784
Autor:
Debra J. Post-Munson, Amy Easton, Carolyn Diane Dzierba, Amy Newton, Yong-Jin Wu, Ronald J. Knox, Kevin J. Robbins, Jason M. Guernon, Clotilde Bourin, Ramkumar Rajamani, Richard E. Olson, James Herrington, Michele Matchett, Kimberly Newberry, John D. Graef, Jianliang Shi, Lorin A. Thompson, Shuya Wang, Jonathan L. Ditta, Nicholas A. Meanwell, Rick L. Pieschl, Matthew G. Soars, Linda J. Bristow, Kathleen W. Mosure
Publikováno v:
Journal of Medicinal Chemistry. 60:2513-2525
By taking advantage of certain features in piperidine 4, we developed a novel series of cyclohexylamine- and piperidine-based benzenesulfonamides as potent and selective Nav1.7 inhibitors. However, compound 24, one of the early analogs, failed to red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70eeeaf9d44c1cee668426b1f9c6fa0f
https://doi.org/10.1021/acs.jmedchem.6b01918
https://doi.org/10.1021/acs.jmedchem.6b01918
Autor:
Hao Wu, Wallace Owen Brendan, Rudolf Jaenisch, John D. Graef, Chicheng Sun, Deena Qadir, Vivian Villegas, Cacace Angela Marie, Stephen T. Warren, Carrie Ng, Kimberly Jesseman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88ed3520eef054f566dea7f2034d099d
https://doi.org/10.1111/ejn.14660/v2/response1
https://doi.org/10.1111/ejn.14660/v2/response1
Autor:
Kimberly Jesseman, Deena Qadir, Chicheng Sun, Wallace Owen Brendan, Hao Wu, John D. Graef, Carrie Ng, Vivian Villegas, Cacace Angela Marie, Stephen T. Warren, Rudolf Jaenisch
Publikováno v:
The European Journal of Neuroscience
Wiley
Wiley
Fragile X syndrome (FXS) is the most common genetic form of intellectual disability caused by a CGG repeat expansion in the 5′‐UTR of the Fragile X mental retardation gene FMR1, triggering epigenetic silencing and the subsequent absence of the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a9bafada3dfc8cfd22dc356b810cf8
https://doi.org/10.1101/608331
https://doi.org/10.1101/608331
Autor:
Craig Polson, John D. Graef, Nina Hoque, Lawrence G. Iben, Yang Cao, Jere E. Meredith, Nino Devidze, Ling Yang, Michael K. Ahlijanian
Synucleinopathies are a group of neurodegenerative diseases characterized by the presence of pathological accumulations of misfolded, phosphorylated α-synuclein (αSyn) protein. Multiple lines of evidence indicate that synucleinopathy disease progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c91ec852b8b0650639d9646e82a1897
Autor:
James Herrington, Shuya Wang, Michael K. Ahlijanian, Nina Hoque, Laszlo Kiss, Kim Newberry, John D. Graef
Publikováno v:
Journal of Neurophysiology. 115:3217-3228
In vitro phenotypic assays of sensory neuron activity are important tools for identifying potential analgesic compounds. These assays are typically characterized by hyperexcitable and/or abnormally, spontaneously active cells. Whereas manual electrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2619cc68ce23df9b69d6ba5a18f4f466
https://doi.org/10.1152/jn.01122.2015
https://doi.org/10.1152/jn.01122.2015
Autor:
Lin Ling, John D. Graef, Chicheng Sun, Anthony Accorsi, Angela Cacace, Natalie Moore, Deena Qadir
Publikováno v:
Circulation Research. 123
Duchenne Muscular Dystrophy (DMD) is a fatal disease of skeletal and cardiac muscle characterized by progressive muscle weakness and atrophy. Current average life expectancy is in the mid-20s and mortality is often linked to end stage cardiomyopathy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35b9b71052a607da1e1aded4db432e1f
https://doi.org/10.1161/res.123.suppl_1.241
https://doi.org/10.1161/res.123.suppl_1.241