Zobrazeno 1 - 10
of 316
pro vyhledávání: '"John D. Elliott"'
Publikováno v:
The American Law Register (1852-1891), 1869 Jul 01. 17(7), 433-436.
Externí odkaz:
https://www.jstor.org/stable/3303781
Autor:
Wei Zhang, Sijie Lu, Ling Zhou, Jia-Ning Xiang, Qian Liu, Yingli Ma, John D. Elliott, Stewart Leung, Yi Li, Liuqing Yang, Feng Ren, Kathleen Zhang, Wang Yonghui, Lisa A. Orband-Miller, Xichen Lin, Zhijun Xiang, Ziqiang Cheng, Qianqian Wu, Ting Yang
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:5293-5302
A novel series of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as RORγt inverse agonists was discovered. Binding mode analysis of a RORγt partial agonist (2c) revealed by co-crystal structure in RORγt LBD suggests that the inverse agonists do not dire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72530aff4a2e5a8933192d8ae588ae65
https://doi.org/10.1016/j.bmc.2015.07.068
https://doi.org/10.1016/j.bmc.2015.07.068
Autor:
Xichen Lin, John D. Elliott, Zhijun Xiang, Han Fangbin, Sijie Lu, Yaobang Cheng, Yan Xu, Stewart Leung, Feng Ren, Yong-Gang Zhao, Wei Cai, Ling Zhou, Qian Liu, Qinghua Meng, Jia-Ning Xiang, Guifeng Zhang, Wang Yonghui, Ziqiang Cheng, Ting Yang, Yafei Huang, Qianqian Wu
Publikováno v:
ACS Medicinal Chemistry Letters. 6:787-792
A novel series of biaryl amides was identified as RORγt inhibitors through core replacement of a starting hit 1. Structure-activity relationship exploration on the biaryl moiety led to discovery of potent RORγt inhibitors with good oral bioavailabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75f4b025d5582c9797c1cbebfdef3ca
https://doi.org/10.1021/acsmedchemlett.5b00122
https://doi.org/10.1021/acsmedchemlett.5b00122
Autor:
Ling Zhou, Sijie Lu, Qianqian Wu, Yong-Gang Zhao, Zhong Zhong, Xichen Lin, Ruina Gao, Melanie Huxdorf, Shuai Wang, Wei Zhang, John D. Elliott, Ziqiang Cheng, Qian Liu, Yingli Ma, Yonghui Wang, Yaobang Cheng, Zhijun Xiang, Ting Yang, Yan Xu, Jia-Ning Xiang, Stewart Leung, Wei Cai, Lisa A. Orband-Miller, Liuqing Yang, Guifeng Zhang, Jing Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:692-702
Novel series of N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides were discovered as potent retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitors. SAR studies of the RORγt HTS hit 6a led to ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266961618b709678a1572f5a6ad4de9c
https://doi.org/10.1016/j.bmc.2013.12.021
https://doi.org/10.1016/j.bmc.2013.12.021
Autor:
Liuqing Yang, Zhijun Xiang, Zhong Zhong, Melanie Huxdorf, Stewart Leung, Xichen Lin, Ling Zhou, Yang Qiu, Ting Yang, Qianqian Wu, John D. Elliott, Wei Zhang, Jia-Ning Xiang, Wei Cai, Qian Liu, Yingli Ma, Yonghui Wang, Yaobang Cheng, Lisa A. Orband-Miller, Jing Zhang
Publikováno v:
ACS Medicinal Chemistry Letters. 5:65-68
A novel series of tertiary amines as retinoid-related orphan receptor gamma-t (RORγt) inverse agonists was discovered through agonist/inverse agonist conversion. The level of RORγt inhibition can be enhanced by modulating the conformational disrupt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72017bdcc523021747bf25673415fde4
https://doi.org/10.1021/ml4003875
https://doi.org/10.1021/ml4003875
Publikováno v:
Tetrahedron Letters. 56:475-477
An efficient and environmental friendly Pd-catalyzed carboxylate-directed C–H arylation reaction of aryl carboxylic acids with iodobenzenes has been developed in water where Tween 20 was added (2% w/w) to form aqueous micelles to increase the solub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::266dd3566670bda7f479b91f2ffcefbb
https://doi.org/10.1016/j.tetlet.2014.12.001
https://doi.org/10.1016/j.tetlet.2014.12.001
Autor:
Xin Cai, Guanghui Deng, Houfu Liu, Feng Ren, John D. Elliott, Jinqiang Zhang, Yang Jiao, Yingli Ma, Xichen Lin, Qing Zhang, Hailong Wang, Liuqing Yang, Wei Zhang, Xiao-Ming Guan, Qiongfeng Xu, Baowei Zhao, Hongtao Lu, Taylor B. Guo, Jia-Ning Xiang
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:6349-6358
We have discovered a novel complex crystal structure of the PHD2 enzyme with its inhibitor, the 2,8-diazaspiro[4.5]decan-1-one analogue 4b. The widely reported salt bridge between Arg383 of the enzyme and its inhibitors in all complex structures publ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc346aa69f80d799cf87bdfa8fa3378
https://doi.org/10.1016/j.bmc.2013.08.046
https://doi.org/10.1016/j.bmc.2013.08.046
Publikováno v:
Tetrahedron Letters. 54:4159-4163
A catalyst-free N–H insertion/Mannich-type reaction cascade of α-nitrodiazoesters with anilines has been developed to afford a variety of α-amino-α-aryl esters in 60–83% yields and under mild reaction conditions (23 or 40 °C).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f6551c49641d9764d339d81219c80dc
https://doi.org/10.1016/j.tetlet.2013.05.131
https://doi.org/10.1016/j.tetlet.2013.05.131
Autor:
Hongtao Lu, Feng Ren, David Jonathan Hirst, John D. Elliott, Xichen Lin, Linbo Luan, Taylor B. Guo, Yonghui Wang, Chengyong Li, Ting Yang, Heng Xu, Haibo Zhang, Matthew J Lindon, Wei Zhang, Yan Xu, Jia-Ning Xiang, Han Fangbin, Yonggang Zhao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2456-2459
High-throughput screening of GSK compound collection led to the discovery of a novel series of thiadiazole amides as potent and S1P3-sparing sphingosine-1-phosphate 1 (S1P1) receptor agonists. Synthesis, structure and activity relationship, selectivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::218b1639ff4120b10cb5fb7730ed4a3d
https://doi.org/10.1016/j.bmcl.2012.02.016
https://doi.org/10.1016/j.bmcl.2012.02.016
Autor:
Andrew A. Parsons, Nambi Aiyar, Eliot H. Ohlstein, A. Jackie Hunter, Pravin Raval, John D. Elliott, Sharon Bingham
Publikováno v:
British Journal of Pharmacology. 126:485-493
The effects of intravenous administration of endothelin (ET) receptor antagonists SB-209670 (0.001–10.0 mg kg−1), SB-217242, SB-234551 (0.01–10.0 mg kg−1) and BQ-788 (0.001–1.0 mg kg−1) were investigated on trigeminal nerve ganglion stimu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0f843a6a254415641c7652757c566c6
https://doi.org/10.1038/sj.bjp.0702306
https://doi.org/10.1038/sj.bjp.0702306