Zobrazeno 1 - 10
of 28
pro vyhledávání: '"John D. Douglass"'
Autor:
Mauricio D. Dorfman, Jordan E. Krull, John D. Douglass, Rachael Fasnacht, Fernando Lara-Lince, Thomas H. Meek, Xiaogang Shi, Vincent Damian, Hong T. Nguyen, Miles E. Matsen, Gregory J. Morton, Joshua P. Thaler
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Unlike males, female mice are resistant to hypothalamic inflammation and weight gain when fed a high-fat diet. Here, the authors reveal sex-specific regulation of hypothalamic microglial activation through CX3CR1 signalling, providing a potential mec
Externí odkaz:
https://doaj.org/article/c3d9bcc58c004e1b9f6eb255e257f3c4
Autor:
John D. Douglass, Yin Xiu Zhou, Amy Wu, John A. Zadroga, Angela M. Gajda, Atreju I. Lackey, Wensheng Lang, Kristen M. Chevalier, Steven W. Sutton, Sui-Po Zhang, Christopher M. Flores, Margery A. Connelly, Judith Storch
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 3, Pp 717- (2019)
Externí odkaz:
https://doaj.org/article/958579d899004c369825ee7df8364455
Autor:
John D. Douglass, Yin Xiu Zhou, Amy Wu, John A. Zadrogra, Angela M. Gajda, Atreju I. Lackey, Wensheng Lang, Kristen M. Chevalier, Steven W. Sutton, Sui-Po Zhang, Christopher M. Flores, Margery A. Connelly, Judith Storch
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 6, Pp 1153-1171 (2015)
Monoacylglycerol lipase (MGL) is a ubiquitously expressed enzyme that catalyzes the hydrolysis of monoacylglycerols (MGs) to yield FFAs and glycerol. MGL contributes to energy homeostasis through the mobilization of fat stores and also via the degrad
Externí odkaz:
https://doaj.org/article/b971bbc51aba493cb64a321bc494f40f
Autor:
Alice C. Wyse-Jackson, Andres Barria, Jineta Banerjee, Joshua P. Thaler, John D. Douglass, Mauricio D. Dorfman, Rachael Fasnacht
Publikováno v:
International Journal of Molecular Sciences. 23:6380
ObjectiveDiet-induced obesity (DIO) is associated with hypothalamic microglial activation and dysfunction of the melanocortin pathway, but the molecular mechanisms linking the two remain unclear. Previous studies have hypothesized that microglial inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edab4aa893b4a3d03b81251b1cdbbb8c
https://doi.org/10.3390/ijms23126380
https://doi.org/10.3390/ijms23126380
Autor:
Joshua P. Thaler, Martin Valdearcos-Contreras, Mauricio D. Dorfman, John D. Douglass, Anzela Niraula, Kelly M. Ness, Suneil K. Koliwad
Publikováno v:
Diabetes. 69
Obesity, a condition affecting more than one in three American adults, is associated with hypothalamic neuronal injury, inflammation, and gliosis- a process characterized by accumulation of activated microglia. Experimental evidence from our lab sugg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1088227aa3aa1ad96ecde05ba4bbf897
https://doi.org/10.2337/db20-1769-p
https://doi.org/10.2337/db20-1769-p
Autor:
John D Douglass, Nashmia eMalik, Su-Hyoun eChon, Kevin eWells, Yin Xiu eZhou, Andrew S. Choi, Laurie B Joseph, Judith eStorch
Publikováno v:
Frontiers in Physiology, Vol 3 (2012)
The ectopic deposition of fat in liver and muscle during obesity is well established, however surprisingly little is known about the intestine. We used the ob/ob mouse and C57BL6/J mice fed a high fat (HF) diet to examine the effects of obesity and t
Externí odkaz:
https://doaj.org/article/24cd34a769e746f1aa1f7ce7a19504ca
Autor:
Su-Hyoun Chon, John D Douglass, Yin Xiu Zhou, Nashmia Malik, Joseph L Dixon, Anita Brinker, Loredana Quadro, Judith Storch
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43962 (2012)
The function of small intestinal monoacylglycerol lipase (MGL) is unknown. Its expression in this tissue is surprising because one of the primary functions of the small intestine is to convert diet-derived MGs to triacylglycerol (TG), and not to degr
Externí odkaz:
https://doaj.org/article/6bbba78106074b319bebe8ae055abf9e
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 6, Iss 4, Pp 366-373 (2017)
Molecular Metabolism, Vol 6, Iss 4, Pp 366-373 (2017)
Objective Obesity and high fat diet (HFD) consumption in rodents is associated with hypothalamic inflammation and reactive gliosis. While neuronal inflammation promotes HFD-induced metabolic dysfunction, the role of astrocyte activation in susceptibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7a654f63e74ce9688a8fb5b5462534
http://europepmc.org/articles/PMC5369266
http://europepmc.org/articles/PMC5369266
Publikováno v:
Diabetes. 67
Obesity and high fat diet (HFD) consumption in rodents is associated with hypothalamic inflammation and activation of microglia, the resident CNS immune cells. Recently, we provided evidence that microglia are critical intermediary cells that transmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52edc4a537707385983bc15285d17b02
https://doi.org/10.2337/db18-371-or
https://doi.org/10.2337/db18-371-or
Autor:
Kristen M. Chevalier, John D. Douglass, Judith Storch, Steven W. Sutton, Sui-Po Zhang, Christopher M. Flores, Yin Xiu Zhou, John A. Zadrogra, Angela M. Gajda, Margery A. Connelly, Atreju I. Lackey, Amy Wu, Wensheng Lang
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 6, Pp 1153-1171 (2015)
Monoacylglycerol lipase (MGL) is a ubiquitously expressed enzyme that catalyzes the hydrolysis of monoacylglycerols (MGs) to yield FFAs and glycerol. MGL contributes to energy homeostasis through the mobilization of fat stores and also via the degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80002248063ffcf6910e9c2f508739d5
http://www.sciencedirect.com/science/article/pii/S0022227520317272
http://www.sciencedirect.com/science/article/pii/S0022227520317272