Zobrazeno 1 - 10
of 15
pro vyhledávání: '"John D. Doran"'
Autor:
Jianglin Liang, Robert J. Davies, James P. Griffith, Hardwin O'dowd, Cameron Stuver Moody, Elaine Krueger, Philip N. Collier, Yusheng Liao, Upul K. Bandarage, Alex Aronov, Jian Wang, Jingrong Cao, Derek B. Lowe, Veronique Damagnez, Elaine Y. Chin, John D. Doran, Emmanuelle Sizensky, Wojciech Dworakowski, Sudipta Mahajan, David D. Deininger, Marc Jacobs, Jinwang Xu, Arnaud Le Tiran, Suvarna Khare-Pandit, Albert C. Pierce, Suganthi Nanthakumar, Ron Grey, David Messersmith, James A. Henderson, Jon H. Come
Publikováno v:
Journal of Medicinal Chemistry. 61:5245-5256
The lipid kinase phosphoinositide 3-kinase γ (PI3Kγ) has attracted attention as a potential target to treat a variety of autoimmune disorders, including multiple sclerosis, due to its role in immune modulation and microglial activation. By minimizi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd9109c79e1ecbf0788c161384fe50c
https://doi.org/10.1021/acs.jmedchem.8b00085
https://doi.org/10.1021/acs.jmedchem.8b00085
Autor:
David Messersmith, Cameron Stuver Moody, Sudipta Mahajan, Yusheng Liao, Upul K. Bandarage, Jinwang Xu, Tiansheng Wang, James P. Griffith, Arnaud Le Tiran, Veronique Damagnez, Elaine Krueger, Setu Roday, Jon H. Come, Kevin M. Cottrell, Brian Ledford, Philip N. Collier, Alex Aronov, Mark W. Ledeboer, Suvarna Khare-Pandit, John D. Doran, Christina Boucher
Publikováno v:
Journal of Medicinal Chemistry. 58:5684-5688
A series of high affinity second-generation thiazolopiperidine inhibitors of PI3Kγ were designed based on some general observations around lipid kinase structure. Optimization of the alkylimidazole group led to inhibitors with higher levels of PI3K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a182fa6e1c15f5980023fc31188413a5
https://doi.org/10.1021/acs.jmedchem.5b00498
https://doi.org/10.1021/acs.jmedchem.5b00498
Autor:
Alex Aronov, Gabriel Martinez-Botella, John D. Doran, Cameron Stuver Moody, Philip N. Collier, Tiansheng Wang, Mark Cornebise, Emilie Porter Huck, James P. Griffith, Francois Maltais, Sudipta Mahajan, Kevin M. Cottrell
Publikováno v:
Journal of Medicinal Chemistry. 58:517-521
Phosphoinositide 3-kinase γ (PI3Kγ) is an attractive target to potentially treat a range of disease states. Herein, we describe the evolution of a reported phenylthiazole pan-PI3K inhibitor into a family of potent and selective benzothiazole inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c859fb78043a075999335a5e53664f
https://doi.org/10.1021/jm500362j
https://doi.org/10.1021/jm500362j
Publikováno v:
Journal of Pharmaceutical Sciences. 101:92-101
Membrane proteins are attractive therapeutic targets, however the presence of detergents complicates biophysical binding measurements. Difficulties in determining quantitative dissociation constants for problematic membrane proteins were addressed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fea915c8562e5a71c0d3a51179800f
https://doi.org/10.1002/jps.22755
https://doi.org/10.1002/jps.22755
Publikováno v:
Biochemistry. 45:7913-7923
Rho-associated coiled-coil kinase, ROCK, is implicated in Rho-mediated cell adhesion and smooth muscle contraction. Animal models suggest that the inhibition of ROCK can ameliorate conditions, such as vasospasm, hypertension, and inflammation. As par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fe169e259d3ff05d5c21f23fd3af56
https://doi.org/10.1021/bi052468q
https://doi.org/10.1021/bi052468q
α-Helix Dipoles and Catalysis: Absorption and Raman Spectroscopic Studies of Acyl Cysteine Proteases
Autor:
John D. Doran, Paul R. Carey
Publikováno v:
Biochemistry. 35:12495-12502
Raman and absorption spectroscopic data are combined with the deacylation rate constants for a series of acyl cysteine proteases to provide insight into the role of α-helix dipoles in rate acceleration. The Raman spectra, obtained by Raman differenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef1951ce31cadefc8a7dc1233e17240a
https://doi.org/10.1021/bi960649+
https://doi.org/10.1021/bi960649+
Autor:
John D, Doran, Marc D, Jacobs
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 468
We describe the protocols for measuring Rho-associated coiled-coil-containing kinase (ROCK) activity in vitro. A His-tagged, constitutively active form of the protein (lacking C-terminal inhibitory domains) is expressed in baculovirus. The protein is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7654a2a725599cf021fcb2739c4273c5
https://pubmed.ncbi.nlm.nih.gov/19099256
https://pubmed.ncbi.nlm.nih.gov/19099256
Autor:
Marc Jacobs, John D. Doran
Publikováno v:
Methods in Molecular Biology ISBN: 9781588299123
We describe the protocols for measuring Rho-associated coiled-coil-containing kinase (ROCK) activity in vitro. A His-tagged, constitutively active form of the protein (lacking C-terminal inhibitory domains) is expressed in baculovirus. The protein is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db3e604b1e813504b1c799f435c799d1
https://doi.org/10.1007/978-1-59745-249-6_15
https://doi.org/10.1007/978-1-59745-249-6_15
Autor:
Mark D. Fleming, John D. Doran, Lora Swenson, Koto Hayakawa, Marc Jacobs, Steven Bellon, Paul Taslimi
Publikováno v:
The Journal of biological chemistry. 281(1)
ROCK or Rho-associated kinase, a serine/threonine kinase, is an effector of Rho-dependent signaling and is involved in actin-cytoskeleton assembly and cell motility and contraction. The ROCK protein consists of several domains: an N-terminal region,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10eb7bb025051fa86617deb27440ff98
https://pubmed.ncbi.nlm.nih.gov/16249185
https://pubmed.ncbi.nlm.nih.gov/16249185
The effect of the length of ROCK (Rho-associated kinase) on its oligomerization state has been investigated by analysing full-length protein and four truncated constructs using light-scattering and analytical ultracentrifugation methods. Changes in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3026918ae8922863625d72b34bfa699
https://europepmc.org/articles/PMC1134108/
https://europepmc.org/articles/PMC1134108/