Zobrazeno 1 - 10
of 273
pro vyhledávání: '"John D. Crispino"'
Autor:
Shannon L. Carey-Smith, Maryam H. Simad, Kunjal Panchal, Carlos Aya-Bonilla, Hannah Smolders, Sang Lin, Jesse D. Armitage, Vivien T. Nguyen, Kathryn Bentley, Jette Ford, Sajla Singh, Joyce Oommen, Anouchka P. Laurent, Thomas Mercher, John D. Crispino, Andrew P. Montgomery, Michael Kassiou, Thierry Besson, Emmanuel Deau, Laurent Meijer, Laurence C. Cheung, Rishi S. Kotecha, Sébastien Malinge
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Not available.
Externí odkaz:
https://doaj.org/article/af0891557ec64135b02d85e7951931e8
Autor:
Liat Stoler-Barak, Ethan Harris, Ayelet Peres, Hadas Hezroni, Mirela Kuka, Pietro Di Lucia, Amalie Grenov, Neta Gurwicz, Meital Kupervaser, Bon Ham Yip, Matteo Iannacone, Gur Yaari, John D. Crispino, Ziv Shulman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Class switch recombination (CSR) is a process by which B cells switch their immunoglobulin isotype and develop pathogen-eliminating antibodies. Here, the authors show that a protein kinase DYRK1A is required for protection from viral infection throug
Externí odkaz:
https://doaj.org/article/431be3cd018542aa832ba2a735ae482b
Autor:
Xinhui Zhao, Boris Bartholdy, Yukiya Yamamoto, Erica K. Evans, Meritxell Alberich-Jordà, Philipp B. Staber, Touati Benoukraf, Pu Zhang, Junyan Zhang, Bon Q. Trinh, John D. Crispino, Trang Hoang, Mahmoud A. Bassal, Daniel G. Tenen
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
The transcription factor PU.1 recruits c-Jun as a co-activator to promoters without AP-1 binding sites, and mice with point mutations in PU.1 that disrupts the interaction between PU1 and c-Jun have defects in PU.1 dependent blood lineages, including
Externí odkaz:
https://doaj.org/article/028cca4501134f47a69fa8a2baa9c31b
Autor:
Diana Saleiro, Jeremy Q. Wen, Ewa M. Kosciuczuk, Frank Eckerdt, Elspeth M. Beauchamp, Chidera V. Oku, Gavin T. Blyth, Mariafausta Fischietti, Liliana Ilut, Marco Colamonici, William Palivos, Paula A. Atsaves, Dean Tan, Masha Kocherginsky, Rona Singer Weinberg, Eleanor N. Fish, John D. Crispino, Ronald Hoffman, Leonidas C. Platanias
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Interferon alpha (IFNalpha) therapy is showing promising results to treat myeloproliferative neoplasms (MPNs). Here, the authors show that IFNalpha response requires ULK1 phosphorylation to induce p38-MAPK signalling but it is counteracted by ROCK1-2
Externí odkaz:
https://doaj.org/article/3a0f1e5129e84efda5acd4754ca85e1b
Autor:
Maria Zingariello, Paola Verachi, Francesca Gobbo, Fabrizio Martelli, Mario Falchi, Maria Mazzarini, Mauro Valeri, Giuseppe Sarli, Christian Marinaccio, Johanna Melo-Cardenas, John D. Crispino, Anna Rita Migliaccio
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 234 (2022)
Serum levels of inflammatory cytokines are currently investigated as prognosis markers in myelofibrosis, the most severe Philadelphia-negative myeloproliferative neoplasm. We tested this hypothesis in the Gata1low model of myelofibrosis. Gata1low mic
Externí odkaz:
https://doaj.org/article/89aee0941e794b8d91d9ee6fea280aad
Autor:
Ioana I. Nitulescu, Sara C. Meyer, Qiang Jeremy Wen, John D. Crispino, Madeleine E. Lemieux, Ross L. Levine, Henry E. Pelish, Matthew D. Shair
Publikováno v:
EBioMedicine, Vol 26, Iss C, Pp 112-125 (2017)
Constitutive JAK-STAT signaling drives the proliferation of most myeloproliferative neoplasms (MPN) and a subset of acute myeloid leukemia (AML), but persistence emerges with chronic exposure to JAK inhibitors. MPN and post-MPN AML are dependent on t
Externí odkaz:
https://doaj.org/article/fed4a5b27cf64d74986dc79cb947a5fb
Autor:
Praveen K Suraneni, John D. Crispino
Publikováno v:
Haematologica, Vol 101, Iss 12 (2016)
Externí odkaz:
https://doaj.org/article/c60a3cf2c4df4d2d8fff8b022f3ccdd1
Publikováno v:
Haematologica, Vol 100, Iss 5 (2015)
GATA1 is a master transcriptional regulator of the differentiation of several related myeloid blood cell types, including erythrocytes and megakaryocytes. Germ-line mutations that cause loss of full length GATA1, but allow for expression of the short
Externí odkaz:
https://doaj.org/article/2039ace4efc8461494dc59c5bd984248
Autor:
Ganesan Keerthivasan, Hui Liu, Jacob M. Gump, Steven F. Dowdy, Amittha Wickrema, John D. Crispino
Publikováno v:
Haematologica, Vol 97, Iss 10 (2012)
Background Nucleus free red blood cells are unique to mammals. During their terminal stage of differentiation, mammalian erythroblasts exit the cell cycle and enucleate. We previously found that survivin, a member of the chromosomal passenger complex
Externí odkaz:
https://doaj.org/article/b77c62554bda4567a3491adbf151c1af
Publikováno v:
Stem Cells International, Vol 2011 (2011)
Even though the production of orthochromatic erythroblasts can be scaled up to fulfill clinical requirements, enucleation remains one of the critical rate-limiting steps in the production of transfusable red blood cells. Mammalian erythrocytes extrud
Externí odkaz:
https://doaj.org/article/12b61911d07a4f6196f6b0eca1015c5f