Zobrazeno 1 - 10
of 27
pro vyhledávání: '"John D. Hayler"'
Autor:
Frank Roschangar, Jun Li, Yanyan Zhou, Wim Aelterman, Alina Borovika, Juan Colberg, David P. Dickson, Fabrice Gallou, John D. Hayler, Stefan G. Koenig, Michael E. Kopach, Birgit Kosjek, David K. Leahy, Erin O’Brien, Austin G. Smith, Manuel Henry, Jutta Cook, Roger A. Sheldon
Publikováno v:
ACS Sustainable Chemistry and Engineering, 10(16)
The large and steadily growing demand for medicines combined with their inherent resource-intensive manufacturing necessitates a relentless push for their sustainable production. Pharmaceutical companies are constantly seeking to perform reliable lif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77447aad8953a5d71e8bac64965dd6a1
https://doi.org/10.1021/acssuschemeng.1c01940
https://doi.org/10.1021/acssuschemeng.1c01940
Autor:
Hugh Clark, Peter Szeto, Robert N. Bream, Alan Ironmonger, John D. Hayler, Nadine Mc Cleary, Alastair J. Roberts, Edney Dean David, Catherine Priestley, Michael R. Webb, Antal Harsanyi, Katherine Wheelhouse, Philip J. Rushworth, Natalie Phillips
Publikováno v:
Organic Process Research & Development. 25:529-540
This paper describes the development of an improved and scalable method for the manufacture of nemiralisib, a phosphatidylinositol-3-kinase delta inhibitor. Incorporation of three consecutive catal...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4d2497481e3451bd75cd43c57a09320
https://doi.org/10.1021/acs.oprd.0c00486
https://doi.org/10.1021/acs.oprd.0c00486
Autor:
Zahra Abbasi, Mohamed Hamada Abdel Kodous, Callie W. Babbitt, Peter M. Budd, Zhen Lei Cheng, Tai-Shung Chung, Marc-Olivier Coppens, Joaquin Coronas, Levente Cseri, Yue Cui, Michael K. Danquah, Enrico Drioli, Arzu Ersöz, Xiaolei Fan, Anthony G. Fane, Maria-Chiara Ferrari, Wen Xiao Gai, Ángel Galán-Martín, Andrés González-Garay, Gonzalo Guillén-Gosálbez, John D. Hayler, Istvan T. Horvath, Jaison Jeevanandam, Yilai Jiao, Martin D. Johnson, C. Oliver Kappe, Rüstem Keçili, Kenta Kokado, Bradley P. Ladewig, Alexei Lapkin, Elsa Lasseuguette, Phantisa Limleamthong, Ryan P. Lively, Andrew Livingston, Yao Ma, Kiyoshi Matsuyama, Farhad Moghadam, Chandran Murugan, Masami Naya, Suzana P. Nunes, Kaushik Pal, Ho Bum Park, Camille Petit, Carlos Pozo, Thalappil Pradeep, Ji Soo Roh, Kazuki Sada, Rıdvan Say, Giulia Schukraft, Varsha Sharma, Jae Eun Shin, Richard L. Smith, Anandhakumar Sundaramurthy, Gyorgy Szekely, Kam C. Tam, Panagiotis Trogadas, Bernhardt L. Trout, Ikuo Ushiki, Luigi Vaccaro, Chun Feng Wan, Huanting Wang, Ecevit Yılmaz, Fengyi Zhang, Xiwang Zhang, Xiangliang Zhang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72db45169b158d1d54efcf88f6beb4fe
https://doi.org/10.1016/b978-0-12-814681-1.01002-x
https://doi.org/10.1016/b978-0-12-814681-1.01002-x
Autor:
Xiangliang Zhang, Anthony G. Fane, Bernhardt L. Trout, C. Oliver Kappe, Joaquín Coronas, Martin D. Johnson, Andrew G. Livingston, István T. Horváth, John D. Hayler, Callie W. Babbitt, Gyorgy Szekely, Thalappil Pradeep, Enrico Drioli, Luigi Vaccaro, Kam Chiu Tam
Publikováno v:
pp. 1–18, 2020
info:cnr-pdr/source/autori:Livingston, Andrew; Trout, Bernhardt L.; Horvath, Istvan T.; Johnson, Martin D.; Vaccaro, Luigi; Coronas, Joaquin; Babbitt, Callie W.; Zhang, Xiangliang; Pradeep, Thalappil; Drioli, Enrico; Hayler, John D.; Tam, Kam C.; Kappe, C. Oliver; Fane, Anthony G.; Szekely, Gyorgy/titolo:Challenges and Directions for Green Chemical Engineering-Role of Nanoscale Materials/titolo_volume:/curatori_volume:/editore:/anno:2020
info:cnr-pdr/source/autori:Livingston, Andrew; Trout, Bernhardt L.; Horvath, Istvan T.; Johnson, Martin D.; Vaccaro, Luigi; Coronas, Joaquin; Babbitt, Callie W.; Zhang, Xiangliang; Pradeep, Thalappil; Drioli, Enrico; Hayler, John D.; Tam, Kam C.; Kappe, C. Oliver; Fane, Anthony G.; Szekely, Gyorgy/titolo:Challenges and Directions for Green Chemical Engineering-Role of Nanoscale Materials/titolo_volume:/curatori_volume:/editore:/anno:2020
Nanotechnology and nanomaterials are among the most significant scientific and industrial research breakthroughs of the 21st century. With the rapid globalization of science, chemists, materials scientists, and chemical engineers are synergistically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db525d0ec43a801ec6ce992dcfcc9a59
http://hdl.handle.net/11391/1458637
http://hdl.handle.net/11391/1458637
Autor:
Ines Pereira Rosinha Grundtvig, John M. Woodley, Patrick Adlercreutz, Søren Heintz, John D. Hayler, Ulrich Krühne, Andy Wells, Krist V. Gernaey
Publikováno v:
Rosinha Grundtvig, I P, Heintz, S, Krühne, U, Gernaey, K V, Adlercreutz, P, Hayler, J D, Wells, A S & Woodley, J M 2018, ' Screening of organic solvents for bioprocesses using aqueous-organic two-phase systems ', Biotechnology Advances, vol. 36, no. 7, pp. 1801-1814 . https://doi.org/10.1016/j.biotechadv.2018.05.007
The application of conventional organic solvents has been essential in several steps of bioprocesses in order to achieve sufficient economic efficiency. The use of organic solvents is frequently used either to partly or fully replace water in the rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753cb8155e895b60c55b136fa13819c6
https://doi.org/10.1016/j.biotechadv.2018.05.007
https://doi.org/10.1016/j.biotechadv.2018.05.007
Publikováno v:
Organometallics. 38:36-46
As companies grow ever more mindful of the sustainability aspects of their products and supply chains, an increasing focus on the environmental impact of pharmaceutical manufacture spurs innovation from chemists who support this industry. Metal catal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ce74ead972d9bf9259b881cbfda13bd
https://doi.org/10.1021/acs.organomet.8b00566
https://doi.org/10.1021/acs.organomet.8b00566
Autor:
Erica Vit, Jerome F. Hayes, Francois-Rene Alexandre, Cyril B. Dousson, Christophe Claude Parsy, David D. Pascoe, Catherine Caillet, Marie-Pierre Lioure, Neil Hodnett, Elodie Rosinovsky, John Edward Richardson, Guillaume Bret, Stéphanie Bot, Agnès Amador, Gary T. Borrett, Bernadette Choudary, Arlène Roland, Daniel Da Costa, Alan Ironmonger, John D. Hayler, Augustine Ochen, Séverine Bonaric, David Colclough, Richard K. Bellingham
Publikováno v:
Organic Process Research & Development. 22:200-206
A new and improved synthetic route to an intermediate in the synthesis of the phosphinate ester GSK2248761A is described. In the key step, we describe the first process-scale example of a palladium-catalyzed phosphorus–carbon coupling to give the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e17aba0e5462710cfa14470fea5b10eb
https://doi.org/10.1021/acs.oprd.7b00356
https://doi.org/10.1021/acs.oprd.7b00356
Autor:
David D. Pascoe, John D. Hayler, Alistair Stewart, Erica Vit, Jingyang Wang, Etridge Stephen K, Celine Bret, Alan Ironmonger, Elaine Smith, Neil Hodnett, Jerome F. Hayes, Adel Moussa, Benjamin Alexander Mayes, Jonathan Stanway
Publikováno v:
Organic Process Research & Development. 22:207-211
Amidation of indole 2-carboxylate 1 with ammonia gas via the imidazolide 2 gave GSK2248761A API 3, which was in development for the treatment of HIV. Three significant impurities, namely the phosphinic acid 4, the N-acyl urea 8, and the indoloyl carb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d738e029ca3bcdc1a2aa848d8a5c8d5
https://doi.org/10.1021/acs.oprd.7b00357
https://doi.org/10.1021/acs.oprd.7b00357
Autor:
David Entwistle, Michael E. Kopach, Matthew R. Hickey, John D. Hayler, Frank Roschangar, Peter J. Dunn, Fabrice Gallou, Shaun Hughes, Franz J. Weiberth, Stefan G. Koenig, Alan Steven, Gerard Moine, Marian C. Bryan, Paul G. Richardson
Publikováno v:
Green Chemistry. 20:5082-5103
In 2007 the members of the ACS Green Chemistry Institute® Pharmaceutical Roundtable assembled a list of key green chemistry research areas to both identify transformations that would benefit from improvements in process greenness and to encourage ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c96b8a6cbe2927cd57622eff9cadbb2
https://doi.org/10.1039/c8gc01276h
https://doi.org/10.1039/c8gc01276h
Autor:
Mark D. McLaws, Zhongbo Fei, Andrew Cosbie, Louis J. Diorazio, Paul G. Richardson, Marian C. Bryan, Timothy D. White, Jingjun Yin, Kenneth J. Fraunhoffer, Matthew R. Hickey, Alan Steven, Shaun Hughes, Gheorghe-Doru Roiban, Markus Schober, John D. Hayler
Publikováno v:
Organic Process Research & Development. 21:1464-1477
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55945dd935d2abd4d6f5e0132f99c156
https://doi.org/10.1021/acs.oprd.7b00292
https://doi.org/10.1021/acs.oprd.7b00292