Zobrazeno 1 - 10
of 152
pro vyhledávání: '"John D. Belcher"'
Autor:
John D. Belcher, Selvaraj Nataraja, Fuad Abdulla, Ping Zhang, Chunsheng Chen, Julia Nguyen, Conglin Ruan, Maneet Singh, Shilpa Demes, Lyndsay Olson, Domi Stickens, Jeff Stanwix, Emer Clarke, Yongzhao Huang, Margaret Biddle, Gregory M. Vercellotti
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
In sickle cell disease (SCD), heme released during intravascular hemolysis promotes oxidative stress, inflammation, and vaso-occlusion. Conversely, free heme can also activate expression of antioxidant and globin genes. Heme binds to the transcriptio
Externí odkaz:
https://doaj.org/article/08d36bbf537a4d62b4156a1ffb787feb
Autor:
Ping Zhang, Julia Nguyen, Fuad Abdulla, Alexander T. Nelson, Joan D. Beckman, Gregory M. Vercellotti, John D. Belcher
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Recent evidence indicates that hemolysis in sickle cell disease (SCD) promotes inflammation via innate immune signaling through toll-like receptor 4 (TLR4). Free heme released by hemolyzed red blood cells can bind to myeloid differentiation factor-2
Externí odkaz:
https://doaj.org/article/8097497790ab421091767ee13d2b3a35
Autor:
Erica M. Sparkenbaugh, Michael W. Henderson, Megan Miller-Awe, Christina Abrams, Anton Ilich, Fatima Trebak, Nirupama Ramadas, Shantel Vital, Dillon Bohinc, Kara L. Bane, Chunsheng Chen, Margi Patel, Michael Wallisch, Thomas Renné, Andras Gruber, Brian Cooley, David Gailani, Malgorzata Kasztan, Gregory M. Vercellotti, John D. Belcher, Felicity E. Gavins, Evi X. Stavrou, Nigel S. Key, Rafal Pawlinski
Publikováno v:
Blood. 141:1871-1883
Data are available on request from the corresponding author, R. Pawlinski (rafal_pawlinski@med.unc.edu). The online version of this article contains a data supplement. The American Society of Hematology A hypercoagulable state, chronic inflammation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8009b33648b9b3ce7fb9415ee11f58c8
https://doi.org/10.1182/blood.2022017074
https://doi.org/10.1182/blood.2022017074
Autor:
Joan D. Beckman, Fuad Abdullah, Chunsheng Chen, Rachel Kirchner, Dormarie Rivera-Rodriguez, Zachary M. Kiser, Aithanh Nguyen, Ping Zhang, Julia Nguyen, Robert P. Hebbel, John D. Belcher, Gregory M. Vercellotti
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Heme, released from red blood cells in sickle cell disease (SCD), interacts with toll-like receptor 4 (TLR4) to activate NF-κB leading to the production of cytokines and adhesion molecules which promote inflammation, pain, and vaso-occlusion. In SCD
Externí odkaz:
https://doaj.org/article/8b85be8fe59f4192a1fe566fbb2c75ec
Autor:
John D. Belcher, Ping Zhang, Julia Nguyen, Zachary M. Kiser, Karl A. Nath, Jianjun Hu, John O. Trent, Gregory M. Vercellotti
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Myeloid differentiation factor-2 (MD-2) binds lipopolysaccharide (LPS) and initiates toll-like receptor-4 (TLR4) pro-inflammatory signaling. Heme also activates TLR4 signaling, but it is unknown if heme interacts with MD-2. Therefore, we examined MD-
Externí odkaz:
https://doaj.org/article/99eb18fc3b6b43cfa494c8c1667c1c26
Autor:
James G. McArthur, Niels Svenstrup, Chunsheng Chen, Aurelie Fricot, Caroline Carvalho, Julia Nguyen, Phong Nguyen, Anna Parachikova, Fuad Abdulla, Gregory M. Vercellotti, Olivier Hermine, Dave Edwards, Jean-Antoine Ribeil, John D. Belcher, Thiago T. Maciel
Publikováno v:
Haematologica, Vol 105, Iss 3 (2020)
The most common treatment for patients with sickle cell disease (SCD) is the chemotherapeutic hydroxyurea, a therapy with pleiotropic effects, including increasing fetal hemoglobin (HbF) in red blood cells and reducing adhesion of white blood cells t
Externí odkaz:
https://doaj.org/article/d6ee0ba0f7734291aed299d4622bb466
Autor:
Ran An, Yuncheng Man, Kevin Cheng, Tianyi Zhang, Chunsheng Chen, Fang Wang, Fuad Abdulla, Erdem Kucukal, William J. Wulftange, Utku Goreke, Allison Bode, Lalitha V. Nayak, Gregory M. Vercellotti, John D. Belcher, Jane A. Little, Umut A. Gurkan
Publikováno v:
British Journal of Haematology. 201:552-563
Endothelial activation and sickle red blood cell (RBC) adhesion are central to the pathogenesis of sickle cell disease (SCD). Quantitatively, RBC-derived extracellular vesicles (REVs) are more abundant from SS RBCs compared with healthy RBCs (AA RBCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76657ad8b6769501b0ea35e857d92c2
https://doi.org/10.1111/bjh.18616
https://doi.org/10.1111/bjh.18616
Autor:
Ran An, Yuncheng Man, Kevin Cheng, Tianyi Zhang, Chunsheng Chen, Erdem Kucukal, William Wulftange, Utku Goreke, Allison Bode, Lalitha Nayak, Gregory M. Vercellotti, John D Belcher, Jane Alison Little, Umut A. Gurkan
Publikováno v:
Blood. 140:8223-8225
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bbe489bee47b29ea10e79a405de2b9c
https://doi.org/10.1182/blood-2022-170438
https://doi.org/10.1182/blood-2022-170438
Autor:
Gregory M Vercellotti, Ping Zhang, Julia Nguyen, Fuad Abdulla, Chunsheng Chen, Phong Nguyen, Carlos Nowotny, Clifford J Steer, Ann Smith, John D Belcher
Publikováno v:
Molecular Medicine, Vol 22, Iss 1, Pp 437-451 (2016)
Abstract Sickle cell disease (SCD) patients have low serum hemopexin (Hpx) levels due to chronic hemolysis. We hypothesized that in SCD mice, hepatic overexpression of hemopexin would scavenge the proximal mediator of vascular activation, heme, and i
Externí odkaz:
https://doaj.org/article/9560498a8c8444a2810e01a74fe7a8ae
Autor:
John D Belcher, Edward Gomperts, Julia Nguyen, Chunsheng Chen, Fuad Abdulla, Zachary M Kiser, David Gallo, Howard Levy, Leo E Otterbein, Gregory M Vercellotti
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205194 (2018)
Carbon monoxide (CO) at low, non-toxic concentrations has been previously demonstrated to exert anti-inflammatory protection in murine models of sickle cell disease (SCD). However CO delivery by inhalation, CO-hemoglobin infusion or CO-releasing mole
Externí odkaz:
https://doaj.org/article/1af0ae6a320f4a209a40e827dfb618ef