Zobrazeno 1 - 10 of 245 pro vyhledávání: '"John D Schuetz"'
1
Akademický článek
Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters.
Autor: Samit Ganguly, David Finkelstein, Timothy I Shaw, Ryan D Michalek, Kimberly M Zorn, Sean Ekins, Kazuto Yasuda, Yu Fukuda, John D Schuetz, Kamalika Mukherjee, Erin G Schuetz
Publikováno v: PLoS ONE, Vol 16, Iss 7, p e0253852 (2021)
Abcg2/Bcrp and Abcb1a/Pgp are xenobiotic efflux transporters limiting substrate permeability in the gastrointestinal system and brain, and increasing renal and hepatic drug clearance. The systemic impact of Bcrp and Pgp ablation on metabolic homeosta
Externí odkaz: https://doaj.org/article/b18f9e558107487fa2603259aa77bcbd
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2
Akademický článek
The absence of mrp4 has no effect on the recruitment of neutrophils and eosinophils into the lung after LPS, cigarette smoke or allergen challenge.
Autor: Jürgen Schymeinsky, Hannah Mayer, Christopher Tomsic, Cornelia Tilp, John D Schuetz, Yunhai Cui, Lutz Wollin, Florian Gantner, Klaus J Erb
Publikováno v: PLoS ONE, Vol 8, Iss 4, p e61193 (2013)
The multidrug resistance protein 4 (Mrp4) is an ATP-binding cassette transporter that is capable of exporting the second messenger cAMP from cells, a process that might regulate cAMP-mediated anti-inflammatory processes. However, using LPS- or cigare
Externí odkaz: https://doaj.org/article/e2e06dc047eb4f51a34e631a7c869e56
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4
Akademický článek
The net electrostatic potential and hydration of ABCG2 affect substrate transport
Autor: Tomoka Gose, Heather M. Aitken, Yao Wang, John Lynch, Evadnie Rampersaud, Yu Fukuda, Medb Wills, Stefanie A. Baril, Robert C. Ford, Anang Shelat, Megan L. O’Mara, John D. Schuetz
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract ABCG2 is a medically important ATP-binding cassette transporter with crucial roles in the absorption and distribution of chemically-diverse toxins and drugs, reducing the cellular accumulation of chemotherapeutic drugs to facilitate multidru
Externí odkaz: https://doaj.org/article/0de3acd6f4884042a8d4c3ec9400e788
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5
Akademický článek
A PPIX-binding probe facilitates discovery of PPIX-induced cell death modulation by peroxiredoxin
Autor: John Lynch, Yao Wang, Yuxin Li, Kanisha Kavdia, Yu Fukuda, Sabina Ranjit, Camenzind G. Robinson, Christy R. Grace, Youlin Xia, Junmin Peng, John D. Schuetz
Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract While heme synthesis requires the formation of a potentially lethal intermediate, protoporphyrin IX (PPIX), surprisingly little is known about the mechanism of its toxicity, aside from its phototoxicity. The cellular protein interactions of
Externí odkaz: https://doaj.org/article/1d1f6d6d8f5b46be92838521e2ff000a
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6
Akademický článek
Development and Validation of a Sensitive and Specific LC-MS/MS Method for IWR-1-Endo, a Wnt Signaling Inhibitor: Application to a Cerebral Microdialysis Study
Autor: Sreenath Nair, Abigail Davis, Olivia Campagne, John D. Schuetz, Clinton F. Stewart
Publikováno v: Molecules, Vol 27, Iss 17, p 5448 (2022)
IWR-1-endo, a small molecule that potently inhibits the Wnt/β-catenin signaling pathway by stabilizing the AXIN2 destruction complex, can inhibit drug efflux at the blood–brain barrier. To conduct murine cerebral microdialysis research, validated,
Externí odkaz: https://doaj.org/article/0978174873e34ab9ab6f8ef978f8098b
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