Výsledky vyhledávání - "John D Schuetz"

Akademický článek

Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters.

Autor: Samit Ganguly, David Finkelstein, Timothy I Shaw, Ryan D Michalek, Kimberly M Zorn, Sean Ekins, Kazuto Yasuda, Yu Fukuda, John D Schuetz, Kamalika Mukherjee, Erin G Schuetz

Publikováno v: PLoS ONE, Vol 16, Iss 7, p e0253852 (2021)

Abcg2/Bcrp and Abcb1a/Pgp are xenobiotic efflux transporters limiting substrate permeability in the gastrointestinal system and brain, and increasing renal and hepatic drug clearance. The systemic impact of Bcrp and Pgp ablation on metabolic homeosta

Externí odkaz: https://doaj.org/article/b18f9e558107487fa2603259aa77bcbd

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Akademický článek

The role of ATP-binding Cassette subfamily B member 6 in the inner ear

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract ABCB6 has been implicated in dyschromatosis universalis hereditaria, a condition characterized by hyperpigmented and hypopigmented skin macules. Dyschromatosis universalis hereditaria can also present with hearing loss. Dyschromatosis univer

Externí odkaz: https://doaj.org/article/4b2b8dd9b6f64e83a7c32805ca68bbac

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Akademický článek

The absence of mrp4 has no effect on the recruitment of neutrophils and eosinophils into the lung after LPS, cigarette smoke or allergen challenge.

Autor: Jürgen Schymeinsky, Hannah Mayer, Christopher Tomsic, Cornelia Tilp, John D Schuetz, Yunhai Cui, Lutz Wollin, Florian Gantner, Klaus J Erb

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e61193 (2013)

The multidrug resistance protein 4 (Mrp4) is an ATP-binding cassette transporter that is capable of exporting the second messenger cAMP from cells, a process that might regulate cAMP-mediated anti-inflammatory processes. However, using LPS- or cigare

Externí odkaz: https://doaj.org/article/e2e06dc047eb4f51a34e631a7c869e56

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Akademický článek

Publisher Correction: The net electrostatic potential and hydration of ABCG2 affect substrate transport

Autor: Tomoka Gose, Heather M. Aitken, Yao Wang, John Lynch, Evadnie Rampersaud, Yu Fukuda, Medb Wills, Stefanie A. Baril, Robert C. Ford, Anang Shelat, Megan L. O’Mara, John D. Schuetz

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)

Externí odkaz: https://doaj.org/article/71a9b8622126468d8a9b749d61a64ec6

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Akademický článek

The net electrostatic potential and hydration of ABCG2 affect substrate transport

Autor: Tomoka Gose, Heather M. Aitken, Yao Wang, John Lynch, Evadnie Rampersaud, Yu Fukuda, Medb Wills, Stefanie A. Baril, Robert C. Ford, Anang Shelat, Megan L. O’Mara, John D. Schuetz

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Abstract ABCG2 is a medically important ATP-binding cassette transporter with crucial roles in the absorption and distribution of chemically-diverse toxins and drugs, reducing the cellular accumulation of chemotherapeutic drugs to facilitate multidru

Externí odkaz: https://doaj.org/article/0de3acd6f4884042a8d4c3ec9400e788

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Akademický článek

A PPIX-binding probe facilitates discovery of PPIX-induced cell death modulation by peroxiredoxin

Autor: John Lynch, Yao Wang, Yuxin Li, Kanisha Kavdia, Yu Fukuda, Sabina Ranjit, Camenzind G. Robinson, Christy R. Grace, Youlin Xia, Junmin Peng, John D. Schuetz

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)

Abstract While heme synthesis requires the formation of a potentially lethal intermediate, protoporphyrin IX (PPIX), surprisingly little is known about the mechanism of its toxicity, aside from its phototoxicity. The cellular protein interactions of

Externí odkaz: https://doaj.org/article/1d1f6d6d8f5b46be92838521e2ff000a

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Akademický článek

Development and Validation of a Sensitive and Specific LC-MS/MS Method for IWR-1-Endo, a Wnt Signaling Inhibitor: Application to a Cerebral Microdialysis Study

Autor: Sreenath Nair, Abigail Davis, Olivia Campagne, John D. Schuetz, Clinton F. Stewart

Publikováno v: Molecules, Vol 27, Iss 17, p 5448 (2022)

IWR-1-endo, a small molecule that potently inhibits the Wnt/β-catenin signaling pathway by stabilizing the AXIN2 destruction complex, can inhibit drug efflux at the blood–brain barrier. To conduct murine cerebral microdialysis research, validated,

Externí odkaz: https://doaj.org/article/0978174873e34ab9ab6f8ef978f8098b

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