Zobrazeno 1 - 8
of 8
pro vyhledávání: '"John D McGeagh"'
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0133372 (2015)
Large-scale conformational change is a common feature in the catalytic cycles of enzymes. Many enzymes function as homodimers with active sites that contain elements from both chains. Symmetric and anti-symmetric cooperative motions in homodimers can
Externí odkaz:
https://doaj.org/article/2a775d972a134ded8a22769c85988db8
Autor:
Axel Walther, John D. McGeagh, Ruta Margelyte, Jenny L Donovan, Richard M. Martin, Niamh M Redmond, Sabi Redwood, Verity Leach
Publikováno v:
Pilot and Feasibility Studies, Vol 4, Iss 1, Pp 1-6 (2017)
Leach, V, Mcgeagh, J, Margelyte, R, Redmond, N, Walther, A, Redwood, S, Martin, R & Donovan, J 2017, ' Facilitating access to health research through a participatory research register : a feasibility study in outpatient clinics ', Pilot and Feasibility Studies, vol. 4, no. 6 . https://doi.org/10.1186/s40814-017-0148-5
Pilot and Feasibility Studies
Leach, V, Mcgeagh, J, Margelyte, R, Redmond, N, Walther, A, Redwood, S, Martin, R & Donovan, J 2017, ' Facilitating access to health research through a participatory research register : a feasibility study in outpatient clinics ', Pilot and Feasibility Studies, vol. 4, no. 6 . https://doi.org/10.1186/s40814-017-0148-5
Pilot and Feasibility Studies
Background: A research register (Reach West) has been established to facilitate recruitment of people and patients to health-related research. We conducted a prospective feasibility study to investigate the practicality of recruiting through outpatie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad0916f54d1310b32fefb7d0c07db6c
http://link.springer.com/article/10.1186/s40814-017-0148-5
http://link.springer.com/article/10.1186/s40814-017-0148-5
Publikováno v:
Wells, S A, Van Der Kamp, M W, Mcgeagh, J D, Mulholland, A J & Soares, C M (ed.) 2015, ' Structure and Function in Homodimeric Enzymes : Simulations of Cooperative and Independent Functional Motions ', PLoS ONE, vol. 10, no. 8, pp. e0133372 . https://doi.org/10.1371/journal.pone.0133372
PLoS ONE
PLoS ONE, Vol 10, Iss 8, p e0133372 (2015)
Wells, S, Van der Kamp, M, Mcgeagh, J & Mulholland, A 2015, ' Structure and Function in Homodimeric Enzymes : Simulations of Cooperative and Independent Functional Motions ', PLoS ONE, vol. 10, no. 8, e0133372 . https://doi.org/10.1371/journal.pone.0133372
PLoS ONE
PLoS ONE, Vol 10, Iss 8, p e0133372 (2015)
Wells, S, Van der Kamp, M, Mcgeagh, J & Mulholland, A 2015, ' Structure and Function in Homodimeric Enzymes : Simulations of Cooperative and Independent Functional Motions ', PLoS ONE, vol. 10, no. 8, e0133372 . https://doi.org/10.1371/journal.pone.0133372
Large-scale conformational change is a common feature in the catalytic cycles of enzymes. Many enzymes function as homodimers with active sites that contain elements from both chains. Symmetric and anti-symmetric cooperative motions in homodimers can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beffb4a0d85243f6d8a413be219e24ae
https://purehost.bath.ac.uk/ws/files/135778099/journal.pone.0133372.pdf
https://purehost.bath.ac.uk/ws/files/135778099/journal.pone.0133372.pdf
Publikováno v:
Angewandte Chemie. 123:10533-10535
The term “lethal synthesis” was coined for enzymatic formation of fluorocitrate, but this classic problem of enzyme stereoselectivity remains poorly understood. Here, we show that high-level ab initio quantum mechanics/ molecular mechanics (QM/MM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14d626cbdf9850e905bcb82a2b97dd2
https://doi.org/10.1002/ange.201103260
https://doi.org/10.1002/ange.201103260
Autor:
Ieva Sutkeviciute, José J. Reina, Angela Berzi, Michel Thépaut, Sara Sattin, Aline Le Roy, Javier Rojo, John D. McGeagh, Mario Clerici, Sergei Grudinin, Anna Bernardi, Christine Ebel, Franck Fieschi, Jörg Weiser
Publikováno v:
ACS Chemical Biology
ACS Chemical Biology, 2014, 9 (6), pp.1377-1385. ⟨10.1021/cb500054h⟩
ACS Chemical Biology, American Chemical Society, 2014, 9 (6), pp.1377-1385. ⟨10.1021/cb500054h⟩
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
ACS Chemical Biology, 2014, 9 (6), pp.1377-1385. ⟨10.1021/cb500054h⟩
ACS Chemical Biology, American Chemical Society, 2014, 9 (6), pp.1377-1385. ⟨10.1021/cb500054h⟩
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
DC-SIGN is a dendritic cell-specific C-type lectin receptor that recognizes highly glycosylated ligands expressed on the surface of various pathogens. This receptor plays an important role in the early stages of many viral infections, including HIV,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cb7c4a03dc472f2d3269de827a3161
https://inria.hal.science/hal-01018565
https://inria.hal.science/hal-01018565
Autor:
John D. McGeagh, Adrian J. Mulholland
Publikováno v:
Challenges and Advances in Computational Chemistry and Physics ISBN: 9789048130337
Molecular modelling and simulation are making increasingly important contributions to the study of the structure and function of biological macromolecules. An area of particular current interest and debate is that of enzyme catalysis, and the role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c879db7596d59ab8358cef57d46e62f
https://doi.org/10.1007/978-90-481-3034-4_14
https://doi.org/10.1007/978-90-481-3034-4_14
Publikováno v:
Value in Health. 16:A326
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e86d971f8012f97f5f0ae3387e95d1e
https://doi.org/10.1016/j.jval.2013.08.021
https://doi.org/10.1016/j.jval.2013.08.021
Autor:
Verity A. Leach, John D. McGeagh, Ruta Margelyte, Niamh M. Redmond, Axel Walther, Sabi Redwood, Richard M. Martin, Jenny L. Donovan
Publikováno v:
Pilot and Feasibility Studies, Vol 4, Iss 1, Pp 1-6 (2017)
Abstract Background A research register (Reach West) has been established to facilitate recruitment of people and patients to health-related research. We conducted a prospective feasibility study to investigate the practicality of recruiting through
Externí odkaz:
https://doaj.org/article/457428b520af4b41a43d2f0b019ceddf