Zobrazeno 1 - 10
of 659
pro vyhledávání: '"John D Lambris"'
Autor:
Jie Zhang, Lihong Song, Dennis V Pedersen, Anna Li, John D Lambris, Gregers Rom Andersen, Tom Eirik Mollnes, Ying Jie Ma, Peter Garred
Publikováno v:
eLife, Vol 9 (2020)
Properdin stabilizes the alternative C3 convertase (C3bBb), whereas its role as pattern-recognition molecule mediating complement activation is disputed for decades. Previously, we have found that soluble collectin-12 (sCL-12) synergizes complement a
Externí odkaz:
https://doaj.org/article/bfba14197f804b95a621fa5dcfd1c4d3
Autor:
Laura Evgin, Carolina S Ilkow, Marie-Claude Bourgeois-Daigneault, Christiano Tanese de Souza, Lawton Stubbert, Michael S Huh, Victoria A Jennings, Monique Marguerie, Sergio A Acuna, Brian A Keller, Charles Lefebvre, Theresa Falls, Fabrice Le Boeuf, Rebecca A Auer, John D Lambris, J Andrea McCart, David F Stojdl, John C Bell
Publikováno v:
Molecular Therapy: Oncolytics, Vol 3, Iss C (2016)
The systemic delivery of therapeutic viruses, such as oncolytic viruses or vaccines, is limited by the generation of neutralizing antibodies. While pseudotyping of rhabdoviruses with the lymphocytic choriomeningitis virus glycoprotein has previously
Externí odkaz:
https://doaj.org/article/03318fbb20d24026bc983751bf71f24d
Autor:
Selene Nunez-Cruz, Phyllis A Gimotty, Matthew W Guerra, Denise C Connolly, You-Qiang Wu, Robert A DeAngelis, John D Lambris, George Coukos, Nathalie Scholler
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 11, Pp 994-1004 (2012)
Complement activation plays a critical role in controlling inflammatory responses. To assess the role of complement during ovarian cancer progression, we crossed two strains of mice with genetic complement deficiencies with transgenic mice that devel
Externí odkaz:
https://doaj.org/article/c4241c79663d4bde830298a77d6442ca
Autor:
Gabriel Forn-Cuní, Edimara S Reis, Sonia Dios, David Posada, John D Lambris, Antonio Figueras, Beatriz Novoa
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99673 (2014)
The complement system acts as a first line of defense and promotes organism homeostasis by modulating the fates of diverse physiological processes. Multiple copies of component genes have been previously identified in fish, suggesting a key role for
Externí odkaz:
https://doaj.org/article/041819efb5a94058bb2e5573d53cc5b2
Autor:
David M Guimond, Nicholas R Cam, Nupura Hirve, Wei Duan, John D Lambris, Michael Croft, Constantine D Tsoukas
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63645 (2013)
The inducible T cell kinase (ITK) regulates type 2 (Th2) cytokines that provide defense against certain parasitic and bacterial infections and are involved in the pathogenesis of lung inflammation such as allergic asthma. Activation of ITK requires t
Externí odkaz:
https://doaj.org/article/edf470c0afbc4eea888e37cb6147f104
Autor:
Guido Moll, Regina Jitschin, Lena von Bahr, Ida Rasmusson-Duprez, Berit Sundberg, Lena Lönnies, Graciela Elgue, Kristina Nilsson-Ekdahl, Dimitrios Mougiakakos, John D Lambris, Olle Ringdén, Katarina Le Blanc, Bo Nilsson
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21703 (2011)
Infusion of human third-party mesenchymal stromal cells (MSCs) appears to be a promising therapy for acute graft-versus-host disease (aGvHD). To date, little is known about how MSCs interact with the body's innate immune system after clinical infusio
Externí odkaz:
https://doaj.org/article/46ae7b796f7f4a8f99da2276c4e3c919
Autor:
Osama A Hamad, Per H Nilsson, Maria Lasaosa, Daniel Ricklin, John D Lambris, Bo Nilsson, Kristina Nilsson Ekdahl
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12889 (2010)
Exposure of chondroitin sulfate A (CS-A) on the surface of activated platelets is well established. The aim of the present study was to investigate to what extent CS-A contributes to the binding of the complement recognition molecule C1q and the comp
Externí odkaz:
https://doaj.org/article/6ad7dfa487854622955246caeafd4fe5
Autor:
Christina Lamers, Xiaoguang Xue, Martin Smieško, Henri van Son, Bea Wagner, Nadja Berger, Georgia Sfyroera, Piet Gros, John D. Lambris, Daniel Ricklin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Therapeutic modulation of the complement system has gained interest over the past two decades. Here, the authors provide molecular-level insight into the mode-of-action, target selectivity and species specificity of the compstatin family of complemen
Externí odkaz:
https://doaj.org/article/0c7331cff4f34721b958795607a6055b
Autor:
Alexandra Gerogianni, Melissa Bal, Camilla Mohlin, Trent M. Woodruff, John D. Lambris, Tom E. Mollnes, Dick J. Sjöström, Per H. Nilsson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Iron oxide nanoparticles (IONPs) are widely used in diagnostic and therapeutic settings. Upon systemic administration, however, they are rapidly recognized by components of innate immunity, which limit their therapeutic capacity and can potentially l
Externí odkaz:
https://doaj.org/article/98f1b9d1f3a24517a729bb9b927be744
Autor:
Thyago Bispo Leonel, Joel José Megale Gabrili, Carla Cristina Squaiella-Baptistão, Trent M. Woodruff, John D. Lambris, Denise V. Tambourgi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The clinical manifestations of envenomation by Bothrops species are complex and characterized by prominent local effects that can progress to tissue loss, physical disability, or amputation. Systemic signs can also occur, such as hemorrhage, coagulop
Externí odkaz:
https://doaj.org/article/d4d0ce99312e44bebecbaeaf558136c0