Zobrazeno 1 - 10
of 214
pro vyhledávání: '"John D Aitchison"'
Autor:
Natalia E Ketaren, Fred D Mast, Peter C Fridy, Jean Paul Olivier, Tanmoy Sanyal, Andrej Sali, Brian T Chait, Michael P Rout, John D Aitchison
Publikováno v:
eLife, Vol 12 (2024)
To date, all major modes of monoclonal antibody therapy targeting SARS-CoV-2 have lost significant efficacy against the latest circulating variants. As SARS-CoV-2 omicron sublineages account for over 90% of COVID-19 infections, evasion of immune resp
Externí odkaz:
https://doaj.org/article/235be37097d94a95a53877f57c2b8848
Autor:
Damian A Oyong, Fergal J Duffy, Maxwell L Neal, Ying Du, Jason Carnes, Katharine V Schwedhelm, Nina Hertoghs, Seong-Hwan Jun, Helen Miller, John D Aitchison, Stephen C De Rosa, Evan W Newell, M Juliana McElrath, Suzanne M McDermott, Kenneth D Stuart
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1011051 (2023)
Understanding immune mechanisms that mediate malaria protection is critical for improving vaccine development. Vaccination with radiation-attenuated Plasmodium falciparum sporozoites (PfRAS) induces high level of sterilizing immunity against malaria
Externí odkaz:
https://doaj.org/article/5e95f5d58ff341c091cc9cbb0bcf49d6
Autor:
Ying Du, Nina Hertoghs, Fergal J Duffy, Jason Carnes, Suzanne M McDermott, Maxwell L Neal, Katharine V Schwedhelm, M Juliana McElrath, Stephen C De Rosa, John D Aitchison, Kenneth D Stuart
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010282 (2022)
Immunization with radiation-attenuated sporozoites (RAS) can confer sterilizing protection against malaria, although the mechanisms behind this protection are incompletely understood. We performed a systems biology analysis of samples from the Immuni
Externí odkaz:
https://doaj.org/article/6c701424a6214177b0d5fae85a2fb05a
Autor:
Whitney E Harrington, Winnie Yeung, Ingrid A Beck, Fred D Mast, John Houck, Sheila Styrchak, Leslie R Miller, Song Li, Micaela Haglund, Yonghou Jiang, Blair Armistead, Jackson Wallner, Tina Nguyen, Daisy Ko, Samantha Hardy, Alyssa Oldroyd, Ana Gervassi, John D Aitchison, Lisa M Frenkel
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274078 (2022)
BackgroundAsymptomatic and pre-symptomatic SARS-CoV-2 infections may contribute to ongoing community transmission, however, the benefit of routine screening of asymptomatic individuals in low-risk populations is unclear.MethodsTo identify SARS-CoV-2
Externí odkaz:
https://doaj.org/article/15dfe1206e9f4c68afbb50aa728d2773
Autor:
Fred D Mast, Peter C Fridy, Natalia E Ketaren, Junjie Wang, Erica Y Jacobs, Jean Paul Olivier, Tanmoy Sanyal, Kelly R Molloy, Fabian Schmidt, Magdalena Rutkowska, Yiska Weisblum, Lucille M Rich, Elizabeth R Vanderwall, Nicholas Dambrauskas, Vladimir Vigdorovich, Sarah Keegan, Jacob B Jiler, Milana E Stein, Paul Dominic B Olinares, Louis Herlands, Theodora Hatziioannou, D Noah Sather, Jason S Debley, David Fenyö, Andrej Sali, Paul D Bieniasz, John D Aitchison, Brian T Chait, Michael P Rout
Publikováno v:
eLife, Vol 10 (2021)
The emergence of SARS-CoV-2 variants threatens current vaccines and therapeutic antibodies and urgently demands powerful new therapeutics that can resist viral escape. We therefore generated a large nanobody repertoire to saturate the distinct and hi
Externí odkaz:
https://doaj.org/article/81f21ae91fa645928a68302720f1052b
Autor:
Yonghou Jiang, Fergal Duffy, Jennifer Hadlock, Andrew Raappana, Sheila Styrchak, Ingrid Beck, Fred D Mast, Leslie R Miller, William Chour, John Houck, Blair Armistead, Venkata R Duvvuri, Winnie Yeung, Micaela Haglund, Jackson Wallner, Julie A Wallick, Samantha Hardy, Alyssa Oldroyd, Daisy Ko, Ana Gervassi, Kim M Murray, Henry Kaplan, John D Aitchison, James R Heath, D Noah Sather, Jason D Goldman, Lisa Frenkel, Whitney E Harrington
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0259902 (2021)
BackgroundCoronavirus disease 2019 (COVID-19) is associated with endothelial activation and coagulopathy, which may be related to pre-existing or infection-induced pro-thrombotic autoantibodies such as those targeting angiotensin II type I receptor (
Externí odkaz:
https://doaj.org/article/3a7ec7eb35a945a696892947a1be46f4
Autor:
Mohsan Saeed, Sebastian Kapell, Nicholas T Hertz, Xianfang Wu, Kierstin Bell, Alison W Ashbrook, Milica Tesic Mark, Henry A Zebroski, Maxwell L Neal, Malin Flodström-Tullberg, Margaret R MacDonald, John D Aitchison, Henrik Molina, Charles M Rice
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008927 (2020)
Viruses cleave cellular proteins to remodel the host proteome. The study of these cleavages has revealed mechanisms of immune evasion, resource exploitation, and pathogenesis. However, the full extent of virus-induced proteolysis in infected cells is
Externí odkaz:
https://doaj.org/article/a0af98e83ecb4080aebefd1e79bfc91f
Autor:
Thurston Herricks, Magdalena Donczew, Fred D Mast, Tige Rustad, Robert Morrison, Timothy R Sterling, David R Sherman, John D Aitchison
Publikováno v:
eLife, Vol 9 (2020)
Antimicrobial-resistant Mycobacterium tuberculosis (Mtb) causes over 200,000 deaths each year. Current assays of antimicrobial resistance need knowledge of mutations that confer drug resistance, or long periods of culture time to test growth under dr
Externí odkaz:
https://doaj.org/article/7f9a4121c902478c82a131e60aa28438
Autor:
Zhuo Wang, Samuel A Danziger, Benjamin D Heavner, Shuyi Ma, Jennifer J Smith, Song Li, Thurston Herricks, Evangelos Simeonidis, Nitin S Baliga, John D Aitchison, Nathan D Price
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 5, p e1005489 (2017)
Gene regulatory and metabolic network models have been used successfully in many organisms, but inherent differences between them make networks difficult to integrate. Probabilistic Regulation Of Metabolism (PROM) provides a partial solution, but it
Externí odkaz:
https://doaj.org/article/eef3b17c074846eb9334aaaa625715af
Autor:
Samuel A Danziger, Leslie R Miller, Karanbir Singh, G Adam Whitney, Elaine R Peskind, Ge Li, Robert J Lipshutz, John D Aitchison, Jennifer J Smith
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178608 (2017)
We have established proof of principle for the Indicator Cell Assay Platform™ (iCAP™), a broadly applicable tool for blood-based diagnostics that uses specifically-selected, standardized cells as biosensors, relying on their innate ability to int
Externí odkaz:
https://doaj.org/article/699cbb26c45a4c37986be6d70bfb887b