Zobrazeno 1 - 10
of 12
pro vyhledávání: '"John D, Wagstaff"'
Publikováno v:
Anesthesia & Analgesia. 104:1514-1520
The synthetic peptide agent Contulakin-G (CGX-1160), isolated from the toxin of the snail Conus geographus, produces significant analgesia in animals. Its peptide structure requires intrathecal administration for effectiveness, therefore we determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a6a780d965d7f9a4f025501de8504d
https://doi.org/10.1213/01.ane.0000262038.58546.e6
https://doi.org/10.1213/01.ane.0000262038.58546.e6
Autor:
Scott J. Low, Baldomero M. Olivera, Grzegorz Bulaj, Doju Yoshikami, T. Patrick Harty, Linda Chicoine, Richard T. Layer, Min Min Zhang, Brian Fiedler, Jacob S. Nielsen, Sue Wei, Heinrich Terlau, Brian D. Klein, John D. Wagstaff, Brad R. Green
Publikováno v:
Biochemistry. 45:7404-7414
μO-Conotoxin MrVIB is a blocker of voltage-gated sodium channels, including TTX-sensitive and -resistant subtypes. A comprehensive characterization of this peptide has been hampered by the lack of sufficient synthetic material. Here, we describe the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2664503a9e290ae412e6bec1367cbab4
https://doi.org/10.1021/bi060159+
https://doi.org/10.1021/bi060159+
Publikováno v:
Brain Research. 721:196-203
The present study was undertaken to examine the role of dopamine D2-receptors in the regulation of neurotensin release. Through a modification of the methods described by Maidment et al. (Neuroscience, 45 (1991) 81–93), we have developed a highly r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254f2c9a36f2e648c9c11736fd451a1a
https://doi.org/10.1016/0006-8993(96)00132-1
https://doi.org/10.1016/0006-8993(96)00132-1
Publikováno v:
Brain Research. 665:237-244
Neurotensin (NT) has been proposed to be an endogenous neuroleptic based on observations that i.c.v. administration of this peptide antagonizes dopamine-mediated behavior. Because NT influences dopamine activity, this peptide may contribute to the pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0a8e35c74373c4897de598c51de301
https://doi.org/10.1016/0006-8993(94)91343-9
https://doi.org/10.1016/0006-8993(94)91343-9
Dynamic dopaminergic regulation of neuropeptide Y systems in discrete striatal and accumbens regions
Autor:
John D. Wagstaff, James W. Gibb, Glen R. Hanson, Lloyd G. Bush, Nanda A. Singh, Leonora P. Midgley
Publikováno v:
European Journal of Pharmacology. 251:191-199
In this study we evaluated the effects of multiple administrations of selective dopamine D1 and D2 receptor agonists and antagonists on striatal, nigral, accumbens, pallidal and cortical neuropeptide Y systems. Treatment with the D1 receptor agonist,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4f199102c7de04147fb5c6e9a38257
https://doi.org/10.1016/0014-2999(94)90400-6
https://doi.org/10.1016/0014-2999(94)90400-6
Autor:
John D. Wagstaff, Tony L. Yaksh, R. Tyler McCabe, Jeffrey W. Allen, Richard T. Layer, Damon McCumber, Katrin Hofer
Publikováno v:
Anesthesia and analgesia. 104(6)
Contulakin-G is a novel conopeptide with an incompletely defined mechanism of action. To assess nociceptive activity we delivered Contulakin-G as a bolus intrathecally (0.03, 0.1, 0.3, 3 nmol) or epidurally (10, 30, 89 nmol) in rats. Intrathecal Cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f8f1d277d765c3f05255c6e721761a
https://pubmed.ncbi.nlm.nih.gov/17513650
https://pubmed.ncbi.nlm.nih.gov/17513650
Autor:
Grzegorz, Bulaj, Min-Min, Zhang, Brad R, Green, Brian, Fiedler, Richard T, Layer, Sue, Wei, Jacob S, Nielsen, Scott J, Low, Brian D, Klein, John D, Wagstaff, Linda, Chicoine, T Patrick, Harty, Heinrich, Terlau, Doju, Yoshikami, Baldomero M, Olivera
Publikováno v:
Biochemistry. 45(23)
MuO-conotoxin MrVIB is a blocker of voltage-gated sodium channels, including TTX-sensitive and -resistant subtypes. A comprehensive characterization of this peptide has been hampered by the lack of sufficient synthetic material. Here, we describe the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d10d3d549fc48fdc1b4161ec648cd6c
https://pubmed.ncbi.nlm.nih.gov/16752929
https://pubmed.ncbi.nlm.nih.gov/16752929
Publikováno v:
Brain research. 1056(2)
The potent NMDA receptor antagonist, Conantokin-G (CGX-1007), a snail peptide, has an 8-h therapeutic window in rat focal cerebral ischemia. We hypothesized that the mechanism of neuroprotection is the inhibition of 'secondary phase' peri-infarct dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09420bea2f3f304d403fb2f1e3274be3
https://pubmed.ncbi.nlm.nih.gov/16112094
https://pubmed.ncbi.nlm.nih.gov/16112094
Publikováno v:
Current medicinal chemistry. 11(23)
Conantokins are small peptides (17-27 amino acids) found in the venoms of cone snails (Conus sp.) that inhibit the activity of N-methyl-D-aspartate (NMDA) receptors. Unlike most of the peptides characterized from cone snail venom that contain multipl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6fc13721bffcf22034eaef9223c0bb
https://pubmed.ncbi.nlm.nih.gov/15579001
https://pubmed.ncbi.nlm.nih.gov/15579001
Autor:
A Vyazovkina, Lourdes J. Cruz, Grzegorz Bulaj, Doju Yoshikami, James E. Garrett, G O Corpuz, J M McIntosh, Baldomero M. Olivera, John D. Wagstaff, Richard T. Layer
Publikováno v:
The Journal of biological chemistry. 275(42)
Cone snails are tropical marine mollusks that envenomate prey with a complex mixture of neuropharmacologically active compounds. We report the discovery and biochemical characterization of a structurally unique peptide isolated from the venom of Conu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4965500fd6a08c5bd0116b324db57c
https://pubmed.ncbi.nlm.nih.gov/10900201
https://pubmed.ncbi.nlm.nih.gov/10900201