Výsledky vyhledávání - "John D, Roberts"

Akademický článek

Alterations in promoter interaction landscape and transcriptional network underlying metabolic adaptation to diet

Autor: Yufeng Qin, Sara A. Grimm, John D. Roberts, Kaliopi Chrysovergis, Paul A. Wade

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Metabolic adaptation to different diets results in changes to gene expression. Here, the authors characterise the chromatin landscape and transcriptional network in mice on a diet of high saturated fat, compared to a diet high in carbohydrate, findin

Externí odkaz: https://doaj.org/article/399f6a117f3b400fae52411f3fe2b896

Zobrazit plný text záznamu

Akademický článek

Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Autor: Lot Snijders Blok, Justine Rousseau, Joanna Twist, Sophie Ehresmann, Motoki Takaku, Hanka Venselaar, Lance H. Rodan, Catherine B. Nowak, Jessica Douglas, Kathryn J. Swoboda, Marcie A. Steeves, Inderneel Sahai, Connie T. R. M. Stumpel, Alexander P. A. Stegmann, Patricia Wheeler, Marcia Willing, Elise Fiala, Aaina Kochhar, William T. Gibson, Ana S. A. Cohen, Ruky Agbahovbe, A. Micheil Innes, P. Y. Billie Au, Julia Rankin, Ilse J. Anderson, Steven A. Skinner, Raymond J. Louie, Hannah E. Warren, Alexandra Afenjar, Boris Keren, Caroline Nava, Julien Buratti, Arnaud Isapof, Diana Rodriguez, Raymond Lewandowski, Jennifer Propst, Ton van Essen, Murim Choi, Sangmoon Lee, Jong H. Chae, Susan Price, Rhonda E. Schnur, Ganka Douglas, Ingrid M. Wentzensen, Christiane Zweier, André Reis, Martin G. Bialer, Christine Moore, Marije Koopmans, Eva H. Brilstra, Glen R. Monroe, Koen L. I. van Gassen, Ellen van Binsbergen, Ruth Newbury-Ecob, Lucy Bownass, Ingrid Bader, Johannes A. Mayr, Saskia B. Wortmann, Kathy J. Jakielski, Edythe A. Strand, Katja Kloth, Tatjana Bierhals, The DDD study, John D. Roberts, Robert M. Petrovich, Shinichi Machida, Hitoshi Kurumizaka, Stefan Lelieveld, Rolph Pfundt, Sandra Jansen, Pelagia Deriziotis, Laurence Faivre, Julien Thevenon, Mirna Assoum, Lawrence Shriberg, Tjitske Kleefstra, Han G. Brunner, Paul A. Wade, Simon E. Fisher, Philippe M. Campeau

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-4 (2019)

The HTML and PDF versions of this Article were updated after publication to remove images of one individual from Figure 1.

Externí odkaz: https://doaj.org/article/360ad6a6ef7c4ee28aed4090b30bd7e5

Zobrazit plný text záznamu

Akademický článek

Utilization, financial outcomes and stakeholder perspectives of a re-organized adult sickle cell program.

Autor: Robert Rousseau, Daniel F Weisberg, Jack Gorero, Vivek Parwani, Janis Bozzo, Kathleen Kenyon, Constance Smith, Joanna Cole, Susanna Curtis, Ariadna Forray, John D Roberts

Publikováno v: PLoS ONE, Vol 15, Iss 7, p e0236360 (2020)

In 2011 Yale New Haven Hospital, in response to high utilization of acute care services and widespread patient and health care personnel dissatisfaction, set out to improve its care of adults living with sickle cell disease. Re-organization component

Externí odkaz: https://doaj.org/article/20f400911a1441949cdd72a68dbf7dfd

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Chromodomain Helicase DNA-binding (CHD) proteins have been implicated in neurodevelopmental processes. Here, the authors identify missense variants in CHD3 that disturb its chromatin remodeling activities and cause a neurodevelopmental disorder with

Externí odkaz: https://doaj.org/article/2f149b8196854879821d3ece66218bf2

Zobrazit plný text záznamu

Akademický článek

Base-Resolution Analysis of DNA Methylation Patterns Downstream of Dnmt3a in Mouse Naïve B Cells

Autor: Christopher G. Duncan, Hrisavgi D. Kondilis-Mangum, Sara A. Grimm, Pierre R. Bushel, Kaliopi Chrysovergis, John D. Roberts, Frederick L. Tyson, B. Alex Merrick, Paul A. Wade

Publikováno v: G3: Genes, Genomes, Genetics, Vol 8, Iss 3, Pp 805-813 (2018)

The DNA methyltransferase, Dnmt3a, is dynamically regulated throughout mammalian B cell development and upon activation by antigenic stimulation. Dnmt3a inactivation in hematopoietic stem cells has been shown to drive B cell-related malignancies, inc

Externí odkaz: https://doaj.org/article/ed04bd6f26a140c3bb06f74d0352d85d

Zobrazit plný text záznamu

Akademický článek

GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network

Autor: Motoki Takaku, Sara A. Grimm, John D. Roberts, Kaliopi Chrysovergis, Brian D. Bennett, Page Myers, Lalith Perera, Charles J. Tucker, Charles M. Perou, Paul A. Wade

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

In breast cancer GATA3 is known to be frequently mutated, but the function of these mutations is unclear. Here, the authors utilise CRISPR-Cas9 to model frame-shift mutations in zinc finger 2 of GATA3, highlighting that GATA3 mutation can have gain-

Externí odkaz: https://doaj.org/article/5f5be941e8644deb8f837c3cb577731d

Zobrazit plný text záznamu

Akademický článek

An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression

Autor: Yufeng Qin, John D. Roberts, Sara A. Grimm, Fred B. Lih, Leesa J. Deterding, Ruifang Li, Kaliopi Chrysovergis, Paul A. Wade

Publikováno v: Genome Biology, Vol 19, Iss 1, Pp 1-14 (2018)

Abstract Background The gut microbiome, a key constituent of the colonic environment, has been implicated as an important modulator of human health. The eukaryotic epigenome is postulated to respond to environmental stimuli through alterations in chr

Externí odkaz: https://doaj.org/article/a7c3bd436bd1434aa58ea834a57aa21d

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání