Zobrazeno 1 - 10
of 138
pro vyhledávání: '"John D, McKinney"'
Autor:
Mélanie T. M. Hannebelle, Esther Raeth, Samuel M. Leitao, Tomáš Lukeš, Jakub Pospíšil, Chiara Toniolo, Olivier F. Venzin, Antonius Chrisnandy, Prabhu P. Swain, Nathan Ronceray, Matthias P. Lütolf, Andrew C. Oates, Guy M. Hagen, Theo Lasser, Aleksandra Radenovic, John D. McKinney, Georg E. Fantner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract Super-resolution techniques expand the abilities of researchers who have the knowledge and resources to either build or purchase a system. This excludes the part of the research community without these capabilities. Here we introduce the ope
Externí odkaz:
https://doaj.org/article/33f09367ca9c4c86ac3975ae417890f1
Autor:
Sophia Gessner, Zela Alexandria-Mae Martin, Michael A Reiche, Joana A Santos, Ryan Dinkele, Atondaho Ramudzuli, Neeraj Dhar, Timothy J de Wet, Saber Anoosheh, Dirk M Lang, Jesse Aaron, Teng-Leong Chew, Jennifer Herrmann, Rolf Müller, John D McKinney, Roger Woodgate, Valerie Mizrahi, Česlovas Venclovas, Meindert H Lamers, Digby F Warner
Publikováno v:
eLife, Vol 12 (2023)
A DNA damage-inducible mutagenic gene cassette has been implicated in the emergence of drug resistance in Mycobacterium tuberculosis during anti-tuberculosis (TB) chemotherapy. However, the molecular composition and operation of the encoded ‘mycoba
Externí odkaz:
https://doaj.org/article/9340d5204dad4cac96d701c78d904d63
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Mycobacterium tuberculosis infection is initiated by the inhalation and implantation of bacteria in the lung alveoli, where they are phagocytosed by macrophages. Even a single bacterium may be sufficient to initiate infection. Thereafter, th
Externí odkaz:
https://doaj.org/article/ca261ba414ae4a62955c0c364dabf224
Autor:
Mélanie T. M. Hannebelle, Joëlle X. Y. Ven, Chiara Toniolo, Haig A. Eskandarian, Gaëlle Vuaridel-Thurre, John D. McKinney, Georg E. Fantner
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Mycobacteria grow by inserting new cell wall material at the cell poles. Here, Hannebelle et al. combine time-lapse optical and atomic force microscopy to show that single-cell growth is biphasic due to a lag phase of variable duration before the new
Externí odkaz:
https://doaj.org/article/279dac6af8c34a219b5d035d89c2b05c
Autor:
Kunal Sharma, Neeraj Dhar, Vivek V Thacker, Thomas M Simonet, Francois Signorino-Gelo, Graham W Knott, John D McKinney
Publikováno v:
eLife, Vol 10 (2021)
Uropathogenic Escherichia coli (UPEC) proliferate within superficial bladder umbrella cells to form intracellular bacterial communities (IBCs) during early stages of urinary tract infections. However, the dynamic responses of IBCs to host stresses an
Externí odkaz:
https://doaj.org/article/f9ed5ed32e464c0989bc1ab76c3a9ee6
Publikováno v:
eLife, Vol 9 (2020)
We establish a murine lung-on-chip infection model and use time-lapse imaging to reveal the dynamics of host-Mycobacterium tuberculosis interactions at an air-liquid interface with a spatiotemporal resolution unattainable in animal models and to prob
Externí odkaz:
https://doaj.org/article/a70932b797244b27ab0d6dcfe4d8ec7e
Publikováno v:
Antibiotics, Vol 10, Iss 7, p 794 (2021)
To reveal rare phenotypes in bacterial populations, conventional microbiology tools should be advanced to generate rapid, quantitative, accurate, and high-throughput data. The main drawbacks of widely used traditional methods for antibiotic studies i
Externí odkaz:
https://doaj.org/article/10e7b22e8bae41ffbafb38865a721746
Autor:
Paul Murima, Michael Zimmermann, Tarun Chopra, Florence Pojer, Giulia Fonti, Matteo Dal Peraro, Sylvie Alonso, Uwe Sauer, Kevin Pethe, John D. McKinney
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Microbes survive in dynamic environments by modulating their intracellular metabolism. Here, the authors reveal that mycobacteria employ a rheostat-like mechanism to regulate carbon flux between the oxidative TCA cycle and the glyoxylate shunt during
Externí odkaz:
https://doaj.org/article/652596cd6de34172bdbad20c07b19e07
Autor:
María Martínez-Hoyos, Esther Perez-Herran, Gulcin Gulten, Lourdes Encinas, Daniel Álvarez-Gómez, Emilio Alvarez, Santiago Ferrer-Bazaga, Adolfo García-Pérez, Fátima Ortega, Iñigo Angulo-Barturen, Joaquin Rullas-Trincado, Delia Blanco Ruano, Pedro Torres, Pablo Castañeda, Sophie Huss, Raquel Fernández Menéndez, Silvia González del Valle, Lluis Ballell, David Barros, Sundip Modha, Neeraj Dhar, François Signorino-Gelo, John D. McKinney, Jose Francisco García-Bustos, Jose Luis Lavandera, James C. Sacchettini, M. Soledad Jimenez, Nuria Martín-Casabona, Julia Castro-Pichel, Alfonso Mendoza-Losana
Publikováno v:
EBioMedicine, Vol 8, Iss C, Pp 291-301 (2016)
Despite being one of the first antitubercular agents identified, isoniazid (INH) is still the most prescribed drug for prophylaxis and tuberculosis (TB) treatment and, together with rifampicin, the pillars of current chemotherapy. A high percentage o
Externí odkaz:
https://doaj.org/article/24f2b3c2204144699909714a57e27a13
Mycobacterium tuberculosis(Mtb) infection is initiated by inhalation of small numbers of bacteria into lung alveoli, where they are phagocytosed by resident macrophages. Intracellular replication ofMtbleads to death of the infected macrophages, relea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b2995901699f9dc159170007fda14be
https://doi.org/10.1101/2023.01.11.523669
https://doi.org/10.1101/2023.01.11.523669
