Zobrazeno 1 - 10
of 153
pro vyhledávání: '"John D, Gearhart"'
Autor:
Angelo H All, Payam Gharibani, Siddharth Gupta, Faith A Bazley, Nikta Pashai, Bin-Kuan Chou, Sandeep Shah, Linda M Resar, Linzhao Cheng, John D Gearhart, Candace L Kerr
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0116933 (2015)
Induced pluripotent stem (iPS) cells are at the forefront of research in regenerative medicine and are envisaged as a source for personalized tissue repair and cell replacement therapy. Here, we demonstrate for the first time that oligodendrocyte pro
Externí odkaz:
https://doaj.org/article/8f86c06791a041e6ba2cfc243b663647
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89678 (2014)
Recent studies have been successful at utilizing ectopic expression of transcription factors to generate induced cardiomyocytes (iCMs) from fibroblasts, albeit at a low frequency in vitro. This work investigates the influence of small molecules that
Externí odkaz:
https://doaj.org/article/ed02d45eaa8a48ffabcd6970c2934a37
Autor:
Nikta Pashai, Haiping Hao, Angelo All, Siddharth Gupta, Raghothama Chaerkady, Alejandro De Los Angeles, John D Gearhart, Candace L Kerr
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39088 (2012)
Human embryonic germ cells (EGCs) provide a powerful model for identifying molecules involved in the pluripotent state when compared to their progenitors, primordial germ cells (PGCs), and other pluripotent stem cells. Microarray and Principal Compon
Externí odkaz:
https://doaj.org/article/f5ca556c4cb1431daf16c3543aa88bfb
Autor:
Russell C Addis, Fu-Chun Hsu, Rebecca L Wright, Marc A Dichter, Douglas A Coulter, John D Gearhart
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28719 (2011)
Direct cellular reprogramming is a powerful new tool for regenerative medicine. In efforts to understand and treat Parkinson's Disease (PD), which is marked by the degeneration of dopaminergic neurons in the midbrain, direct reprogramming provides a
Externí odkaz:
https://doaj.org/article/364f29015cae470780f9ac0d200fe2db
Autor:
Nicolas Christoforou, Behzad N Oskouei, Paul Esteso, Christine M Hill, Jeffrey M Zimmet, Weining Bian, Nenad Bursac, Kam W Leong, Joshua M Hare, John D Gearhart
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11536 (2010)
Stem cell transplantation holds great promise for the treatment of myocardial infarction injury. We recently described the embryonic stem cell-derived cardiac progenitor cells (CPCs) capable of differentiating into cardiomyocytes, vascular endotheliu
Externí odkaz:
https://doaj.org/article/8c475f1a024e488ab8fcafd8e0daa1f7
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10480 (2010)
BACKGROUND: Cells of the oligodendrocyte (OL) lineage play a vital role in the production and maintenance of myelin, a multilamellar membrane which allows for saltatory conduction along axons. These cells may provide immense therapeutic potential for
Externí odkaz:
https://doaj.org/article/b475a5bfe71243c49a63cbb3eabb4f56
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2176 (2008)
Remarkably, although cardiac disease accounts for the largest proportion of adult mortality and morbidity in the industrialized world, the genetic programs controlling early cardiogenesis are largely incompletely understood. To better understand this
Externí odkaz:
https://doaj.org/article/68c643f4174e43e38b849bfb7d0ade42
Publikováno v:
The International Journal of Developmental Biology. 60:327-336
In 2016, a symposium was convened in Leroy C. Stevens' honor, in association with a meeting of the International Stem Cell Initiative (ISCI). ISCI, funded internationally, is composed of a group of ~100 scientists from many countries, under the leade
Autor:
John D. Gearhart, Elias T. Zambidis, Haiping Hao, Xuan Yuan, Faith A. Bazley, Cyndi F. Liu, Candace L. Kerr, Angelo H. All, Alejandro De Los Angeles
Publikováno v:
Stem Cells and Development. 24:2634-2648
Primordial germ cells (PGCs) share many properties with embryonic stem cells (ESCs) and innately express several key pluripotency-controlling factors, including OCT4, NANOG, and LIN28. Therefore, PGCs may provide a simple and efficient model for stud
Publikováno v:
Science. 356:139-140
Scientific discoveries and new technologies that aim to improve human health challenge our understanding of what it means to be human. Perceptions of being and the boundaries between humans and other species may be disrupted by our potential to manip