Zobrazeno 1 - 10
of 19
pro vyhledávání: '"John D, Bagert"'
Autor:
John D. Bagert, Vaheh Oganesyan, Chi-I Chiang, Mike Iannotti, Jia Lin, Chunning Yang, Sterling Payne, Will McMahon, Samuel Edwards, Andrew Dippel, Mark Hutchinson, Fengying Huang, Vineela Aleti, Chendi Niu, Chen Qian, Jessica Denham, Sofia Ferreira, Pallab Pradhan, Mark Penney, Chunlei Wang, Wenhai Liu, Even Walseng, Yariv Mazor
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTBispecific antibodies represent an increasingly large fraction of biologics in therapeutic development due to their expanded scope in functional capabilities. Asymmetric monovalent bispecific IgGs (bsIgGs) have the additional advantage of mai
Externí odkaz:
https://doaj.org/article/2704cd42c0734221bbfa24115f8720e9
Autor:
Bradley J. Lukasak, Robert E. Thompson, Michelle M. Mitchener, Vanessa J. Feng, John D. Bagert, Tom W. Muir
Publikováno v:
ACS Central Science, Vol 8, Iss 2, Pp 176-183 (2022)
Externí odkaz:
https://doaj.org/article/f58a12d675eb480c86cb6a52d7a60009
Autor:
Caroline E. Weller, Abhinav Dhall, Feizhi Ding, Edlaine Linares, Samuel D. Whedon, Nicholas A. Senger, Elizabeth L. Tyson, John D. Bagert, Xiaosong Li, Ohara Augusto, Champak Chatterjee
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Chemical approaches to site-specifically ubiquitylate a target protein allow investigation of the biochemical effects of this modification, but they often destabilize the protein. Here, the authors report on a synthetic conjugation strategy that lead
Externí odkaz:
https://doaj.org/article/b48cef68f3dc4e9fa4b70b0add885ae3
Autor:
Lijuan Feng, Felix Wojcik, Barbara E. Dul, John D. Bagert, Agata L Patriotis, Benjamin A. Nacev, Michelle M. Mitchener, C. David Allis, Tom W. Muir
Publikováno v:
Nature chemical biology
Whole-genome sequencing data mining efforts have revealed numerous histone mutations in a wide range of cancer types. These occur in all four core histones in both the tail and globular domains and remain largely uncharacterized. Here we used two hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0156b24fed333db19d38d4767d9c539e
https://doi.org/10.1038/s41589-021-00738-1
https://doi.org/10.1038/s41589-021-00738-1
Publikováno v:
Nature Chemistry. 12:520-527
Elucidating the physiological binding partners of histone post-translational modifications (hPTMs) is key to understanding fundamental epigenetic regulatory pathways. Determining such interactomes will enable the study of how perturbations of these i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b923cfd8e34b53bddeed7350b72c634
https://doi.org/10.1038/s41557-020-0474-8
https://doi.org/10.1038/s41557-020-0474-8
Autor:
Bradley J. Lukasak, Robert E. Thompson, Michelle M. Mitchener, Vanessa J. Feng, John D. Bagert, Tom W. Muir
Publikováno v:
ACS central science. 8(2)
Nucleosomes frequently exist as asymmetric species in native chromatin contexts. Current methods for the traceless generation of these heterotypic chromatin substrates are inefficient and/or difficult to implement. Here, we report an application of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7d9702f36df208235ca4be88dcc7d5
https://pubmed.ncbi.nlm.nih.gov/35233450
https://pubmed.ncbi.nlm.nih.gov/35233450
Publikováno v:
Journal of the American Chemical Society. 143(29)
ADP-ribosylation of nuclear proteins is a critical feature of various DNA damage repair pathways. Histones, particularly H3 and H2B, are major targets of ADP-ribosylation and are primarily modified on serine with a single ADP-ribose unit following DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b505a83089694f30c35a6178a5ce4929
https://pubmed.ncbi.nlm.nih.gov/34264659
https://pubmed.ncbi.nlm.nih.gov/34264659
Autor:
Tom W. Muir, John D. Bagert
Publikováno v:
Annu Rev Biochem
The field of epigenetics has exploded over the last two decades, revealing an astonishing level of complexity in the way genetic information is stored and accessed in eukaryotes. This expansion of knowledge, which is very much ongoing, has been made
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b46a4aac414179e54fb51c0f545645
https://europepmc.org/articles/PMC8284505/
https://europepmc.org/articles/PMC8284505/
Autor:
Nikolaus Schultz, C. David Allis, Agata E. Lemiesz, Benjamin A. Nacev, Lijuan Feng, Alexey A. Soshnev, Ritika Kundra, John D. Bagert, Tom W. Muir, Jianjiong Gao
Publikováno v:
Nature
Mutations in epigenetic pathways are common oncogenic drivers. Histones, the fundamental substrates for chromatin-modifying and remodelling enzymes, are mutated in tumours including gliomas, sarcomas, head and neck cancers, and carcinosarcomas. Class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c43ef3a48ecac812d3cb0842c50e9a5
https://doi.org/10.1038/s41586-019-1038-1
https://doi.org/10.1038/s41586-019-1038-1
Autor:
Andrew R. D’Avino, Martin Filipovski, John D. Bagert, Hai T. Dao, Akshay Sankar, Nazar Mashtalir, Hengyuan Liu, Brittany C. Michel, Aaron J. Corin, Cigall Kadoch, Eva J. Ge, Geoffrey P. Dann, Tom W. Muir
Publikováno v:
Signal Transduction and Targeted Therapy
Chromatin landscape dictates remodeling Large, multicomponent molecular machines known as mammalian SWI/SNF (mSWI/SNF) chromatin-remodeling complexes play critical roles in governing the architecture of our genomes. These entities bind to chromatin (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65599606b03203f3a91d5b4ff35c9a9c
https://pubmed.ncbi.nlm.nih.gov/34615852
https://pubmed.ncbi.nlm.nih.gov/34615852