Zobrazeno 1 - 10
of 92
pro vyhledávání: '"John D, Ash"'
Autor:
Yixiao Wang, Silke Becker, Stella Finkelstein, Frank M. Dyka, Haitao Liu, Mark Eminhizer, Ying Hao, Richard S. Brush, William J. Spencer, Vadim Y. Arshavsky, John D. Ash, Jianhai Du, Martin-Paul Agbaga, Frans Vinberg, Jessica M. Ellis, Ekaterina S. Lobanova
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract The retina is light-sensitive neuronal tissue in the back of the eye. The phospholipid composition of the retina is unique and highly enriched in polyunsaturated fatty acids, including docosahexaenoic fatty acid (DHA). While it is generally
Externí odkaz:
https://doaj.org/article/ad85367e74fe4ef684827fbc22b57206
Autor:
Lei Xu, Emily E. Brown, Clayton P. Santiago, Casey J. Keuthan, Ekaterina Lobanova, John D. Ash
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101700- (2020)
Peroxisome proliferator-activated receptors (PPARs) are a family of three nuclear hormone receptors (PPARα, PPARδ, and PPARγ) that are known to regulate expression of lipid metabolism and oxidative stress genes. Given their role in reducing oxidat
Externí odkaz:
https://doaj.org/article/1241fff1d60447eeb5be46e2d845e683
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Retinal degeneration is a common cause of irreversible blindness and is caused by the death of retinal light-sensitive neurons called photoreceptors. At the onset of degeneration, stressed photoreceptors cause retinal glial cells to secrete
Externí odkaz:
https://doaj.org/article/d7b55eaf54594d6dae1bfe7115a90f6e
Publikováno v:
Redox Biology, Vol 24, Iss , Pp - (2019)
Age-related macular degeneration (AMD) is the leading cause of vision loss in the western world. Recent evidence suggests that RPE and photoreceptors have an interconnected metabolism and that mitochondrial damage in RPE is a trigger for degeneration
Externí odkaz:
https://doaj.org/article/d3a20b25ebc14cf2835db514ad5d3d29
Publikováno v:
Neurobiology of Disease, Vol 34, Iss 3, Pp 535-544 (2009)
Preconditioning with moderate oxidative stress (e.g., moderate bright light or mild hypoxia) can induce changes in retinal tissue that protect photoreceptors from a subsequent dose of lethal oxidative stress. The mechanism underlying this induced pro
Externí odkaz:
https://doaj.org/article/9a3bd12b1cf648089b25a38641f20f84
Autor:
Lei Xu, Omar Akil, William W. Hauswirth, Seth Blackshaw, Clayton Santiago, Frank M. Dyka, John D. Ash, Susan Bolch, Kirill A. Martemyanov, James T. Handa, Astra Dinculescu, W. Clay Smith, Ekaterina S. Lobanova, Yuchen Wang
Publikováno v:
The Journal of Pathology
Usher syndrome type 3 (USH3) is an autosomal recessively inherited disorder caused by mutations in the gene clarin‐1 (CLRN1), leading to combined progressive hearing loss and retinal degeneration. The cellular distribution of CLRN1 in the retina re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7eaf5732e656afd4ef0c9337185882
http://europepmc.org/articles/PMC7003947
http://europepmc.org/articles/PMC7003947
Autor:
Deborah A, Ferrington, M Cristina, Kenney, Shari R, Atilano, James B, Hurley, Emily E, Brown, John D, Ash
Publikováno v:
Advances in experimental medicine and biology. 1256
Strong experimental evidence from studies in human donor retinas and animal models supports the idea that the retinal pathology associated with age-related macular degeneration (AMD) involves mitochondrial dysfunction and consequent altered retinal m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::89418aa20dbb7887b143ef4eb24382fe
https://pubmed.ncbi.nlm.nih.gov/33848005
https://pubmed.ncbi.nlm.nih.gov/33848005
Autor:
John D. Ash, Eric Pierce, Robert E. Anderson, Catherine Bowes Rickman, Joe G. Hollyfield, Christian Grimm
This book contains the proceedings of the XVIII International Symposium on Retinal Degeneration (RD2018). A majority of those who spoke and presented posters at the meeting contributed to this volume. The blinding diseases of inherited retinal degene
Autor:
Eloide-Kim Grellier, Jerome E. Roger, Jianhai Du, John D. Ash, Casey Keuthan, Emily E. Brown, Anand Swaroop, Himani Gubbi, Lei Xu
The retina has one of the highest energy demands in the human body, and proper regulation of metabolism among the cell types of the retina is required for functional vision. Recent studies have reported that retinal metabolism is disrupted during ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57077dc5b78bfdfe38ed4a85fa22de63
https://doi.org/10.1101/2020.05.22.109165
https://doi.org/10.1101/2020.05.22.109165
Autor:
John D. Ash, Matthew M. LaVail, Christian Grimm, Joe G. Hollyfield, Robert E. Anderson, Catherine Bowes Rickman
Publikováno v:
Retinal Degenerative Diseases ISBN: 9783030273774
The title of the chapter is "Melatonin as the Possible Link Between Age-Related Retinal Degeneration and the Disrupted Circadian Rhythm in Elderly" but degeneration was incorrectly published as regeneration. Now this has been corrected to degeneratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a45b8b0f6b0c49f4a56b572e6108bef
https://doi.org/10.1007/978-3-030-27378-1_95
https://doi.org/10.1007/978-3-030-27378-1_95