Výsledky vyhledávání - "John D, Altman"

Akademický článek

Frequency-potency analysis of IgG+ memory B cells delineates neutralizing antibody responses at single-cell resolution

Publikováno v: Cell Reports, Vol 43, Iss 3, Pp 113948- (2024)

Summary: Identifying individual functional B cell receptors (BCRs) is common, but two-dimensional analysis of B cell frequency versus BCR potency would delineate both quantity and quality of antigen-specific memory B cells. We efficiently determine q

Externí odkaz: https://doaj.org/article/cffa39d3f17347089105277e097050f5

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Akademický článek

A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids

Autor: Adam Shahine, Peter Reinink, Josephine F. Reijneveld, Stephanie Gras, Mira Holzheimer, Tan-Yun Cheng, Adriaan J. Minnaard, John D. Altman, Steffi Lenz, Jacques Prandi, Joanna Kubler-Kielb, D. Branch Moody, Jamie Rossjohn, Ildiko Van Rhijn

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

CD1 proteins present lipid antigens to T cells via the T cell receptor. Here the authors describe T cell reactivity to human membrane lipid moieties and provide structural data to define a molecular mechanism of promiscuous recognition of self-derive

Externí odkaz: https://doaj.org/article/8b688ab776554395acd758b05b541c3e

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Akademický článek

Casting a wider net: Immunosurveillance by nonclassical MHC molecules.

Publikováno v: PLoS Pathogens, Vol 15, Iss 2, p e1007567 (2019)

Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological significance based on recognition

Externí odkaz: https://doaj.org/article/cc3b6392d68c4db2b0fca2712a8da0c6

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Akademický článek

Empty conformers of HLA-B preferentially bind CD8 and regulate CD8+ T cell function

Autor: Jie Geng, John D Altman, Sujatha Krishnakumar, Malini Raghavan

Publikováno v: eLife, Vol 7 (2018)

When complexed with antigenic peptides, human leukocyte antigen (HLA) class I (HLA-I) molecules initiate CD8+ T cell responses via interaction with the T cell receptor (TCR) and co-receptor CD8. Peptides are generally critical for the stable cell sur

Externí odkaz: https://doaj.org/article/4cfd285677144d24a10f9b72ec46393e

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Akademický článek

Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU).

Autor: Kelin Li, Charles K Vorkas, Ashutosh Chaudhry, Donielle L Bell, Richard A Willis, Alexander Rudensky, John D Altman, Michael S Glickman, Jeffrey Aubé

Publikováno v: PLoS ONE, Vol 13, Iss 2, p e0191837 (2018)

Mucosal-associated invariant T (MAIT) cells are an abundant class of innate T cells restricted by the MHC I-related molecule MR1. MAIT cells can recognize bacterially-derived metabolic intermediates from the riboflavin pathway presented by MR1 and ar

Externí odkaz: https://doaj.org/article/b8d8a84305a44bfeaa50be5431426c8b

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Akademický článek

Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques.

Publikováno v: PLoS Pathogens, Vol 13, Iss 7, p e1006529 (2017)

The ability to control lentivirus replication may be determined, in part, by the extent to which individual viral proteins are targeted by the immune system. Consequently, defining the antigens that elicit the most protective immune responses may fac

Externí odkaz: https://doaj.org/article/7f9298477dd24bad881bb9021f08cf80

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T Cells Specific for a Mycobacterial Glycolipid Expand after Intravenous Bacillus Calmette–Guérin Vaccination

Autor: Robert A. Seder, John D. Altman, Soumik Barman, Mario Roederer, Patricia A. Darrah, Damien B. Wilburn, Adriaan J. Minnaard, Erik D. Layton, Krystle K. Q. Yu, Malisa T. Smith, Chetan Seshadri, Nabil Tahiri, Thomas J. Scriba

Publikováno v: J Immunol
Journal of Immunology, 206(6), 1240-1250. AMER ASSOC IMMUNOLOGISTS

Intradermal vaccination with Mycobacterium bovis bacillus Calmette–Guérin (BCG) protects infants from disseminated tuberculosis, and i.v. BCG protects nonhuman primates (NHP) against pulmonary and extrapulmonary tuberculosis. In humans and NHP, pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace1a7f73d2b059219b4121aa3d7ffab
https://doi.org/10.4049/jimmunol.2001065

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Minimal Information about MHC Multimers (MIAMM)

Autor: Randi Vita, Apurva Mody, James A. Overton, Soren Buus, Stephen T. Haley, Alessandro Sette, Vamsee Mallajosyula, Mark M. Davis, Dale L. Long, Richard A. Willis, Bjoern Peters, John D. Altman

Publikováno v: J Immunol

With the goal of improving the reproducibility and annotatability of MHC multimer reagent data, we present the establishment of a new data standard: Minimal Information about MHC Multimers (https://miamm.lji.org/). Multimers are engineered reagents c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca083f01783f9b3c3ccdff8b3ee5a19
https://europepmc.org/articles/PMC8830768/

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