Zobrazeno 1 - 10
of 91
pro vyhledávání: '"John Cuppoletti"'
Autor:
Meghali P Nighot, Prashant K Nighot, Thomas Y Ma, Danuta H Malinowska, Gary E Shull, John Cuppoletti, Anthony T Blikslager
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138174 (2015)
The present studies were designed to examine the effects of ClC-2 ablation on cellular morphology, parietal cell abundance, H/K ATPase expression, parietal cell ultrastructure and acid secretion using WT and ClC-2-/- mouse stomachs. Cellular histolog
Externí odkaz:
https://doaj.org/article/177186bc2cbb4f79acdc6d88009881ef
Publikováno v:
American Journal of Physiology-Cell Physiology. 312:C707-C723
Fatty acids (including lubiprostone and cobiprostone) are human ClC-2 (hClC-2) Cl−channel activators. Molecular and cellular mechanisms underlying this activation were examined. Role of a four-amino acid PKA activation site, RGET691, of hClC-2 was
Autor:
Qiang Yue, Ling Yu, Amity F. Eaton, Douglas C. Eaton, Hui-Fang Bao, John Cuppoletti, He-Ping Ma
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1848(11):2859-2867
This investigation was conducted to study the relationship between intracellular Ca(2+) and activation of large conductance Ca(2+)-activated K(+) (BK) currents by unoprostone, the first synthetic docosanoid. We used HEK293 cells stably transfected wi
Autor:
John Cuppoletti
Publikováno v:
American Journal of Physiology-Cell Physiology. 311:C544-C546
The nuclear envelope (NE) consists of two continuous membranes, with pores where the inner nuclear membrane (INM) meets the outer nuclear membrane (ONM). V-Type ATPases in the plasma membrane and intracellular membranes alter pH (ΔpH) and generate a
Publikováno v:
American Journal of Physiology-Cell Physiology. 307:C479-C492
It has been difficult to separate/identify the roles of ClC-2 and CFTR in Cl−transport studies. Using pharmacological agents, we aimed to differentiate functionally between ClC-2 and CFTR Cl−channel currents. Effects of CFTR inhibitor 172 (CFTRin
Autor:
Wenbao Hu, Ying Sun, Zhenguo Wu, Yuanyuan Duan, Thomas M. Magin, Pingbo Huang, Yan Wang, Xu Cao, Changyan Xie, Fan Zhang, John Cuppoletti, Dong Wang, Wei Kevin Zhang, Haixia Wang, Ning Li
Publikováno v:
Journal of Biological Chemistry. 287:40547-40559
CFTR function is tightly regulated by many interacting proteins.Intermediate filament protein keratin 18 increases the cell surface expression of CFTR by interacting with the C-terminal hydrophobic patch of CFTR.K18 controls the function of CFTR.Thes
Publikováno v:
Ion Channels and Transporters of Epithelia in Health and Disease ISBN: 9781493933648
Studies of Epithelial Transporters and Ion Channels ISBN: 9783030554538
Studies of Epithelial Transporters and Ion Channels ISBN: 9783030554538
This article focuses on activators and inhibitors of ClC-2. ClC-2 Cl− channels from mouse, rabbit, rat, and human have been studied extensively in recombinant form by whole-cell patch-clamp and in single-channel studies. There are similarities in r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dba2191779edcbb7fc03c3d11a8e89b
https://doi.org/10.1007/978-1-4939-3366-2_15
https://doi.org/10.1007/978-1-4939-3366-2_15
Publikováno v:
Prostaglandins & Other Lipid Mediators. 86:56-60
Lubiprostone, a bicyclic fatty acid derivative and member of a new class of compounds called prostones, locally activates ClC-2 Cl − channels without activation of prostaglandin receptors. The present study was specifically designed to test and com
Publikováno v:
The FASEB Journal. 29
Objective: HBE cells contain both ClC-2 and CFTR Cl- channels. The objective was to identify the Cl- channel in HBE cells that is activated by the prostone, cobiprostone (cobi) using knockdowns and...
Autor:
Ann M. Sherry, Myra L. Patchen, John Cuppoletti, Kirti P. Tewari, Qiu-ju Li, Ryuji Ueno, Danuta H. Malinowska
Publikováno v:
American Journal of Physiology-Cell Physiology. 287:C1173-C1183
The purpose of this study was to determine the mechanism of action of SPI-0211 (lubiprostone), a novel bicyclic fatty acid in development for the treatment of bowel dysfunction. Adult rabbit intestine was shown to contain mRNA for ClC-2 using RT-PCR,