Zobrazeno 1 - 3
of 3
pro vyhledávání: '"John Cuozzo"'
Autor:
Stefania Canè, Roza Maria Barouni, Marina Fabbi, John Cuozzo, Giulio Fracasso, Annalisa Adamo, Stefano Ugel, Rosalinda Trovato, Francesco De Sanctis, Mauro Giacca, Rita Lawlor, Aldo Scarpa, Borislav Rusev, Gabriella Lionetto, Salvatore Paiella, Roberto Salvia, Claudio Bassi, Susanna Mandruzzato, Silvano Ferrini, Vincenzo Bronte
Publikováno v:
Science Translational Medicine. 15
Myeloid cells can restrain antitumor immunity by metabolic pathways, such as the degradation of l -arginine, whose concentrations are regulated by the arginase 1 (ARG1) enzyme. Results from preclinical studies indicate the important role of arginine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d2cf6285800245e71e9f8809e797ca
https://doi.org/10.1126/scitranslmed.abq6221
https://doi.org/10.1126/scitranslmed.abq6221
Autor:
Ying Zhang, Anthony Keefe, Paolo Centrella, John Cuozzo, Holly Soutter, Daniel Resnicow, Sevan Habeshian, Matt Clark
Publikováno v:
Cancer Research. 83:5331-5331
Increasingly drug discovery programs require the development of orally available and cell permeable classes of drugs derived from the chemical space beyond Lipinski’s rule of 5 (bRO5). The chameleon-like physicochemical properties and differentiate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e90906f0fa2796ed6934bc0068c331a9
https://doi.org/10.1158/1538-7445.am2023-5331
https://doi.org/10.1158/1538-7445.am2023-5331
Autor:
Zhengrong, Zhu, John, Cuozzo
Publikováno v:
Journal of biomolecular screening. 14(10)
High-throughput affinity-based technologies are rapidly growing in use as primary screening methods in drug discovery. In this review, their principles and applications are described and their impact on small-molecule drug discovery is evaluated. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5a62a2a97992754ffaecf571f498e9ce
https://pubmed.ncbi.nlm.nih.gov/19822881
https://pubmed.ncbi.nlm.nih.gov/19822881