Zobrazeno 1 - 10
of 38
pro vyhledávání: '"John Coughlin"'
Autor:
Allyson Kwiatkowski, Carl Co, Sei Kameoka, An Zhang, John Coughlin, Tom Cameron, Eric Chiao, Svetlana Bergelson, Cullen Schmid Mason
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
The terminal sugars of Fc glycans can influence the Fc-dependent biological activities of monoclonal antibody therapeutics. Afucosylated N-glycans have been shown to significantly alter binding to FcγRIIIa and affect antibody-dependent cell-mediated
Externí odkaz:
https://doaj.org/article/de7297e0eace436aacfb3a8b6386340a
Autor:
John Coughlin
Publikováno v:
Horizons. 46:348-354
At the outset of Ethics at the Edges of Law: Christian Moralists and American Legal Thought, Cathleen Kaveny explains that the purpose of her book is to impart new energy to the interdisciplinary conversation between Christian ethicists and legal sch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::510c3c698db51474db9b89568c1ba388
https://doi.org/10.1017/hor.2019.109
https://doi.org/10.1017/hor.2019.109
Autor:
John Coughlin
Publikováno v:
Journal of Church and State. 62:561-563
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2813a75f9af0a624101cd10a4d99072d
https://doi.org/10.1093/jcs/csaa046
https://doi.org/10.1093/jcs/csaa046
Autor:
John Coughlin, Allyson Kwiatkowski, Carl Co, Svetlana Bergelson, An Zhang, Cullen Schmid Mason, Eric Chiao, Sei Kameoka, Thomas Cameron
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The terminal sugars of Fc glycans can influence the Fc-dependent biological activities of monoclonal antibody therapeutics. Afucosylated N-glycans have been shown to significantly alter binding to FcγRIIIa and affect antibody-dependent cell-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2583d749ae4e4fb41a919d528026d3
http://europepmc.org/articles/PMC7531570
http://europepmc.org/articles/PMC7531570
Publikováno v:
Maria Sharapova: Banishment from WTA Tour and a Loss of Sponsorship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20dadd739a79277dc8e9c30e75042d95
https://doi.org/10.4135/9781526444790
https://doi.org/10.4135/9781526444790
Autor:
John Coughlin, Jeremiah P. Malerich, Seetharamaiyer Padmanabhan, Sung-Whi Rhee, Mary J. Tanga, Radhakrishnan P. Iyer
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 55:197-200
The 35S-labeled, dinucleoside phosphorothioate 1, an orally available agent against hepatitis B virus, was prepared in eight steps with high specific activity and radiochemical purity. Radiolabeled 3H-benzodithiole-3-one-1,1-dioxide was synthesized i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::349b533205515695e4a818de7b946557
https://doi.org/10.1002/jlcr.2925
https://doi.org/10.1002/jlcr.2925
Autor:
John Coughlin, Rajendra K. Pandey, Seetharamaiyer Padmanabhan, Radhakrishnan P. Iyer, Jon C. Mirsalis, Carol E. Green, Judith Marquis, Kathleen O’Loughlin
Publikováno v:
Drug Metabolism and Disposition. 40:970-981
The alkoxycarbonyloxy dinucleotide prodrug R(p), S(p)-2 is an orally bioavailable anti-hepatitis B virus agent. The compound is efficiently metabolized to the active dinucleoside phosphorothioate R(p), S(p)-1 by human liver microsomes and S9 fraction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37dc26562d0006a91bfff2f2c9ce95f
https://doi.org/10.1124/dmd.111.044446
https://doi.org/10.1124/dmd.111.044446
Autor:
Cassandra Kirk, Guangrong Zhang, Jon C. Mirsalis, John Coughlin, John D. Morrey, Brent E. Korba, Carol E. Green, Chandrika P. Govardhan, Radhakrishnan P. Iyer, Seetharamaiyer Padmanabhan, Kathleen O’Loughlin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1783-1786
The acyloxyalkyl derivatives of a model anti-HBV dinucleotide were synthesized and evaluated as orally bioavailable prodrugs. Our studies have led to the identification of the first orally bioavailable dinucleotide prodrugs for further therapeutic de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b421b8657375e1896ab57d4eb3387c2
https://doi.org/10.1016/j.bmcl.2010.01.010
https://doi.org/10.1016/j.bmcl.2010.01.010