Zobrazeno 1 - 10 of 48 pro vyhledávání: '"John Coombs"'
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Akademický článek
Developing professional judgement in surgical trainees: the role of critical reflection
Autor: Timothy William Gray, Christopher John Coombs
Publikováno v: Australasian Journal of Plastic Surgery, Vol 1, Iss 1 (2018)
Critical reflection is a disciplined process that aims to critically evaluate everyday medical practices to more fully understand and learn from them. It can lead to improved professionalism and clinical reasoning and is increasingly seen as a core c
Externí odkaz: https://doaj.org/article/5b209485bbee4161936c37f57fbf9cd1
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2
Pd(0)-Catalyzed Directed syn-1,2-Carboboration and -Silylation: Alkene Scope, Applications in Dearomatization, and Stereocontrol via a Chiral Auxiliary
Autor: Zhen Liu, Jiahao Chen, Xiaohan Li, Yang Gao, John Coombs, Matthew Goldfogel, Keary Engle
We report the development of palladium(0)-catalyzed syn-selective 1,2-carboboration and -silylation reactions of alkenes containing cleavable directing groups. With B2pin2or PhMe2Si–Bpin as nucleophiles and aryl/alkenyl triflates as electrophiles,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f04c2369379062b30d837a52c3fd118
https://doi.org/10.26434/chemrxiv.8865143
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3
The Patient Journey in Chronic Myeloid Leukemia Patients on Tyrosine Kinase Inhibitor Therapies: Qualitative Insights Using a Global Ethnographic Approach
Autor: Marc Paolantonio, Ari Shapiro, Nancy J. Macdonald, Oleg Zernovak, John Coombs, François Guilhot, Christina Bender, Tomasz Szczudlo
Publikováno v: The Patient - Patient-Centered Outcomes Research. 6:81-92
The advent and approval of tyrosine kinase inhibitors (TKIs) have dramatically improved the life expectancy of patients with chronic myeloid leukemia (CML), which has been transformed into a chronically manageable disease.The objective was to qualita
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960929ef42a51f201bfa7e149d29397f
https://doi.org/10.1007/s40271-013-0006-3
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4
Cost-effectiveness of 3-years of adjuvant imatinib in gastrointestinal stromal tumors (GIST) in the United States
Autor: Marc Paolantonio, Myrlene Sanon, Medha Sasane, John Coombs, Anju Parthan, Douglas C.A. Taylor
Publikováno v: Journal of Medical Economics. 16:150-159
Recent clinical trial data have demonstrated that 3 years vs 1 year of adjuvant imatinib therapy for patients with surgically resected Kit+ Gastrointestinal Stromal Tumors (GIST) leads to a significant improvement in recurrence-free survival and over
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70269af0e3aa4bbffd749d5f2a579e71
https://doi.org/10.3111/13696998.2012.709204
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5
Adherence to oral tyrosine kinase inhibitor therapies in chronic myeloid leukemia
Autor: Delphine Rea, Linda Abetz-Webb, Louise Heron, John Coombs, Adam Gater, François Guilhot, Jeff Simmons
Publikováno v: Leukemia Research. 36:817-825
Ensuring adherence to therapy is a challenge in chronic diseases, particularly in cancers such as chronic myeloid leukemia (CML), where there has been increased availability and use of oral formulations. A conceptual model of adherence was developed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3892a8cd83537438a6f11c87804769ac
https://doi.org/10.1016/j.leukres.2012.01.021
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7
Budgetary Impact of Treatment with Adjuvant Imatinib for 1 Year Following Surgical Resection of Kit-Positive Localized Gastrointestinal Stromal Tumors
Autor: Jamie L. Rubin, Myrlene Sanon, John Coombs, Douglas C.A. Taylor, Vamsi Bollu
Publikováno v: Journal of Managed Care Pharmacy. 16:482-491
BACKGROUND: Imatinib mesylate, an orally administered kinase inhibitor that targets the KIT (CD117) protein, currently has 10 approved indications including treatment of chronic myelogenous leukemia and metastatic gastrointestinal stromal tumors (GIS
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b21ed8e530d3d01c16067ff88a63a7
https://doi.org/10.18553/jmcp.2010.16.7.482
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8
Healthcare resource utilization and costs associated with non-adherence to imatinib treatment in chronic myeloid leukemia patients
Autor: Vamsi Bollu, Nicolas Beaulieu, John Coombs, Jorge E. Cortes, Weiwei Feng, Mateo Arana, Eric Q. Wu, Amy Guo, Scott J. Johnson
Publikováno v: Current Medical Research and Opinion. 26:61-69
Patients with chronic myeloid leukemia (CML) who do not adhere to treatment may experience suboptimal outcomes.To examine the association between adherence with imatinib and direct healthcare costs and resource utilization in a large group of private
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4e527037e61ea7c1ede51dbb56b8e2
https://doi.org/10.1185/03007990903396469
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10
Comparison of different adjuvant therapies for 9 resectable cancer types
Autor: Anju Parthan, Morgan Kruse, Douglas C.A. Taylor, John Coombs, Medha Sasane
Publikováno v: Postgraduate medicine. 125(2)
The objective of this study was to compare the clinical benefit across adjuvant therapies for cancer treatment, including adjuvant imatinib, and to quantify the results using the number-needed-to-treat (NNT) approach.We reviewed studies meeting the f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4cc5d910ceac79aa75ab6cf299633a8
https://pubmed.ncbi.nlm.nih.gov/23816774
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