Zobrazeno 1 - 10
of 17
pro vyhledávání: '"John Concannon"'
Autor:
Abhisek Mukherjee, Kathleen Syeb, John Concannon, Keri Callegari, Claudio Soto, Marcie A Glicksman
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131297 (2015)
Currently there is no effective treatment available for major neurodegenerative disorders associated to protein misfolding, including Alzheimer's and Parkinson's disease. One of most promising therapeutic approaches under development focuses on inhib
Externí odkaz:
https://doaj.org/article/92bb068364854089bcc698154bb86ba5
Autor:
Xinming Cai, Zinger Yang, John S. Reece-Hoyes, Edmund Harrington, John Alford, Tim Schuhmann, Luis Llamas, Rob Maher, Alicia Lindeman, Stephen M. Canham, Irina Alimov, Nadire Cochran, Carsten Russ, Suchithra Menon, Gregory R. Hoffman, Qiong Wang, John Concannon
Publikováno v:
Journal of Biological Chemistry. 294:3359-3366
Bile acids are critical metabolites in the gastrointestinal tract and contribute to maintaining intestinal immune homeostasis through cross-talk with the gut microbiota. The conversion of bile acids by the gut microbiome is now recognized as a factor
Autor:
Andrea Hadjikyriacou, Sangeetha Iyer, Joshua D. Mast, Nina DiPrimio, John Concannon, Joshua Ketterman, Frederic Sigoillot, Tamy P. Rodriguez, Feba S. Sam, Hillary Tsang, Madeleine Prangley, Julide Bilen, Kausalya Murthy, Tom A. Hartl, Christophe Antczak, Jeremy L Jenkins, Nathan T. Ross, Beat Nyfeler, Rishi K. Jain, John A. Tallarico, Ethan O. Perlstein, Stephen M. Canham
Invertebrate model organisms (the nematode Caenorhabditis elegans and the fruit fly Drosophila melanogaster) are valuable tools to bridge the gap between traditional in vitro discovery and preclinical animal models. Invertebrate model organisms are p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96724114f0536d920b8fc593b93f63bf
https://doi.org/10.1101/2021.03.05.434120
https://doi.org/10.1101/2021.03.05.434120
Autor:
Ceryl Tan, Miriam B. Ginzberg, Rachel Webster, Seshu Iyengar, Shixuan Liu, John Concannon, Yuan Wang, Douglas S. Auld, Jeremy L. Jenkins, Hannes Rost, Andreas Hilfinger, W. Brent Derry, Nish Patel, Ran Kafri
SUMMARYWhile molecules that promote the growth of animal cells have been identified, the following question remains: How are growth promoting pathways regulated to specify a characteristic size for each of the different cell types? In 1975, Hartwell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfe4e50d087f3da2e714e52c2a7a54e7
https://doi.org/10.1101/2020.10.14.339556
https://doi.org/10.1101/2020.10.14.339556
Autor:
Thomas M. Smith, Douglas S. Auld, YounKyoung Lee, Shin Numao, Seth Carbonneau, Scott A. Busby, Christoph E. Dumelin, Nicole A. Renaud, John Concannon
Publikováno v:
ACS chemical biology. 15(10)
Assays drive drug discovery from the exploratory phases to the clinical testing of drug candidates. As such, numerous assay technologies and methodologies have arisen to support drug discovery efforts. Robust identification and characterization of tr
Autor:
Douglas S. Auld, Rachel L. Webster, Ceryl Tan, Ran Kafri, W. Brent Derry, Shixuan Liu, Nish Patel, John Concannon, Miriam Bracha Ginzberg, Yuan Wang, Hannes L. Röst, Jeremy L. Jenkins, Andreas Hilfinger, Seshu Iyengar, David Papadopoli, Ivan Topisirovic
Publikováno v:
Dev Cell
While molecules that promote the growth of animal cells have been identified, it remains unclear how such signals are orchestrated to determine a characteristic target size for different cell types. It is increasingly clear that cell size is determin
Autor:
Liz S. Wilson, Joseph Cruz, David J. Glass, John Concannon, Berndt Oberhauser, Brian A. Clarke, Yunyu Zhang, Anne-Ulrike Trendelenburg, Yuan Wang, Krystyna Patora-Komisarska, Nicole Hupper
Facioscapulohumeral muscular dystrophy (FSHD) is among the most prevalent of the adult-onset muscular dystrophies. FSHD causes a loss of muscle mass and function, resulting in severe debilitation and reduction in quality of life. Currently, only the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5284eae687a42f1af0f10d5516593b33
https://europepmc.org/articles/PMC6066320/
https://europepmc.org/articles/PMC6066320/
Autor:
Dariusz Pytel, Kathleen Seyb, Min Liu, Gregory D. Cuny, John Concannon, J. Alan Diehl, Soumya S. Ray, Mickey Huang, Marcie A. Glicksman
Publikováno v:
SLAS Discovery. 19:1024-1034
PERK is serine/threonine kinase localized to the endoplasmic reticulum (ER) membrane. PERK is activated and contributes to cell survival in response to a variety of physiological stresses that affect protein quality control in the ER, such as hypoxia
Autor:
Fangqi Gu, Sudhir H. Ranganath, Oren Levy, Luke J. Mortensen, Jeffrey M. Karp, Marcie A. Glicksman, Kathleen Seyb, Keir Martyn, John Concannon, Weian Zhao, Charles P. Lin, Zhixiang Tong, Kelvin S. Ng, Zijiang Yang
Publikováno v:
Scientific Reports
Nature
Nature
Pre-treatment or priming of mesenchymal stem cells (MSC) prior to transplantation can significantly augment the immunosuppressive effect of MSC-based therapies. In this study, we screened a library of 1402 FDA-approved bioactive compounds to prime MS
Autor:
Juan C. Caicedo, Csaba Molnar, Anne E. Carpenter, Shantanu Singh, Florian Heigwer, Roger G. Linington, Holger Hennig, John Concannon, Joseph Barry, Aliaksei Vasilevich, Peng Qiu, Lassi Paavolainen, Mathias Wawer, Jane Hung, Sam Cooper, Oren Kraus, Mohammad Hossein Rohban, Scott Warchal, Ian Smith, Paul A. Clemons, Paul Rees, Markus D. Herrmann, Harmanjit Singh Bansal, Peter Horvath
Publikováno v:
Nature Methods
This Review covers the steps required to create high-quality image-based profiles from high-throughput microscopy images.
Image-based cell profiling is a high-throughput strategy for the quantification of phenotypic differences among a variety o
Image-based cell profiling is a high-throughput strategy for the quantification of phenotypic differences among a variety o