Zobrazeno 1 - 10
of 63
pro vyhledávání: '"John Colyer"'
Autor:
Sabine Lotteau, PhD, Niklas Ivarsson, PhD, Zhaokang Yang, PhD, Damien Restagno, PhD, John Colyer, PhD, Philip Hopkins, MD, Andrew Weightman, PhD, Koichi Himori, MSc, Takashi Yamada, PhD, Joseph Bruton, PhD, Derek Steele, PhD, Håkan Westerblad, MD, PhD, Sarah Calaghan, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 4, Pp 509-523 (2019)
Summary: This study aimed to identify a mechanism for statin-induced myopathy that explains its prevalence and selectivity for skeletal muscle, and to understand its interaction with moderate exercise. Statin-associated adverse muscle symptoms reduce
Externí odkaz:
https://doaj.org/article/78f53b25bad64710b444c80cfadf25d9
Autor:
Thomas M. D. Sheard, Miriam E. Hurley, Andrew J. Smith, John Colyer, Ed White, Izzy Jayasinghe
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 377
Clusters of ryanodine receptor calcium channels (RyRs) form the primary molecular machinery of intracellular calcium signalling in cardiomyocytes. While a range of optical super-resolution microscopy techniques have revealed the nanoscale structure o
Clusters of ryanodine receptor calcium channels (RyRs) form the primary molecular machinery in cardiomyocytes. Various adaptations of super-resolution microscopy have revealed intricate details of the structure, molecular composition and locations of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7520ab6b7d095b2988595c6972bb133
https://doi.org/10.1101/2021.10.21.462365
https://doi.org/10.1101/2021.10.21.462365
Autor:
John Colyer, Stephen P. Muench, Adrian Whitehouse, Andrew J. Smith, Sophie Schumann, Karen E. Porter, K. E. Wright
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Detection of protein biomarkers is an important tool for medical diagnostics, typically exploiting concentration of particular biomarkers or biomarker release from tissues. We sought to establish whether proteins not normally released by living cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b65e4124348bd35b18b5ffd0fff67f
https://eprints.whiterose.ac.uk/154084/1/s41598-019-51896-1.pdf
https://eprints.whiterose.ac.uk/154084/1/s41598-019-51896-1.pdf
Publikováno v:
Chemical communications (Cambridge, England). 52(14)
Given the dependence of much modern biology upon the use of antibodies as tools and reagents, their variability and the often associated lack-of-detail about function and identity creates experimental errors. Here we describe the proof-of-principle f
Publikováno v:
Cell Biology International. 32:1388-1396
The plasma membrane of the heart muscle cell and its underlying cytoskeleton are vitally important to the function of the heart. Annexin A6 is a major cellular calcium and phospholipid binding protein. Here we show that annexin A6 copurifies with sar
Autor:
Benjamin R. G. Johnson, John Colyer, Richard J. Bushby, Khizar H. Sheikh, Robert E. Miles, Richard J. Barfoot, Stephen D. Evans, Lars J. C. Jeuken
Publikováno v:
Langmuir. 24:6827-6836
Preferential binding of F-actin to lipid bilayers containing ponticulin was investigated on both planar supported bilayers and on a cholesterol-based tethering system. The transmembrane protein ponticulin in Dictyostelium discoideum is known to provi
Publikováno v:
Biophysical Journal. 91(2):433-443
The space between the t-tubule invagination and the sarcoplasmic reticulum (SR) membrane, the dyad, in ventricular myocytes has been predicted to experience very high [Ca2+] for short periods of time during a Ca2+ transient. The dyadic space accommod
Publikováno v:
Journal of Biological Chemistry. 279:17111-17119
The phosphorylation of the cardiac muscle isoform of the sarcoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA2a) on serine 38 has been described as a regulatory event capable of very significant enhancement of enzyme activity (Hawkins, C., Xu, A., and Na
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 279:H1963-H1971
The effects of short (1 min) and long (7–10 min) exposure to hyposmotic solution on excitation-contraction coupling in rat ventricular myocytes were studied. After short exposure, the action potential duration at 90% repolarization (APD90), the int